Institute of Medicine / Institutionen för medicin: Recent submissions
Now showing items 41-60 of 1073
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Clinical challenges in Cushing's syndrome
(2022-04-28)Cushing’s syndrome (CS) is caused by prolonged exposure to cortisol excess. CS is associated with cardiovascular diseases, infections, and fractures, as well as with cognitive impairment and affective disorders. This thesis, ... -
Cause-Specific Mortality and Physical Fitness in Mental Disorders - Epidemiological and Internventional Studies
(2022-04-28)Mental illnesses are common and constitute a substantial health-related and financial burden on both the individual and society. Mental disorders in general have increased risk of somatic morbidity. An early age of onset ... -
Hypertoniscreening - Tidig upptäckt av högt blodtryck via tandvården
(2022-04-25)Background: Hypertension is the main risk factor for the world’s total disease burden. This is of significance for public health at national level, for healthcare professionals, resource consumption and costs as well as ... -
Thymic exosomes - effects on selection and maturation of thymocytes
(2022-04-22)T cell tolerance is primarily shaped in the thymus, through direct and indirect presentation of self-antigens to developing T cells. Medullary thymic epithelial cells (mTECs), producing and expressing self-antigens, together ... -
Health locus of control, depressive symptoms, and insulin resistance. Implications for treatment and prevention in general population and primary care
(2022-04-14)The disease burden of type 2 diabetes and depression is large and challenging for healthcare systems. Preventive interventions require resources and better knowledge concerning early stages in the development of these ... -
The role of the gut microbiota in central energy balance regulation
(2022-04-11)The gut microbiota can affect development and metabolism in the host. Today, much is still unknown regarding the effects of the gut microbiota on central energy balance regulation. We used mouse models to determine the ... -
Prognosis and clinical outomes in stroke patients with transcatheter closure of an atrial shunt
(2022-03-16)Background: The percutaneous transcatheter closure of a patent foramen ovale (PFO) after a cryptogenic cerebrovascular event (CVE) has been performed for more than two decades. In contrast with previous randomized studies, ... -
Prediction models for planning health care resources. During the first wave of the Covid-19 pandemic 2020
(University of Gothenburg, 2022)Due to the Covid-19 pandemic, has emphasized a need for planning health care resources based on only a few aggregated data points and little knowledge of the data-generating process. In the first part of the report, we ... -
Metabolic alterations and adipose tissue dysfunction in individuals with a family history of type 2 diabetes
(2022-02-08)ABSTRACT Aims The overall aim of this doctoral thesis was to further examine the anthropometric, metabolic and adipose tissue dysfunctions, as well as explore novel metabolites, associated with type 2 diabetes mellitus ... -
Unmet need for mental healthcare among men Sweden: Gendered pathways to care
(2022-02-02)Aim: Depression and anxiety disorders have a lifetime prevalence of about 10% among men in high-income countries but many do not seek and receive the care that they need. The aim of this thesis was to explore gendered ... -
Predictors of bone fragility in older women. Associations in older women between risk medications and measurements of physical function, bone microstructure and fracture risk
(2021-12-20)Bone fragility with fractures constitutes a growing public health concern, resulting in suffering and major health care cost. This thesis project has been carried out by means of studies based on the SUPERB cohort of ... -
Luftvägsvirus vid arbetsplatser - Smittvägar, riskfaktorer och skyddsåtgärder
(GÖTEBORGS UNIVERSITET Avd för Samhällsmedicin och Folkhälsa, 2021-12-06)Att spridning av sjukdomsframkallande luftvägsvirus kostar samhället enorma resurser har blivit uppenbart för alla under covid-19, men ovälkomna virus har varit människans följeslagare genom hela historien och ständigt ... -
Physicians' practices in sickness certification for common mental disorders - assessment of work capacity and communication with the patient's workplace
(2021-11-25)Physicians are key stakeholders in the sickness certification process. The first aim of this thesis was to examine physicians’ sickness certification practices from two perspectives: the assessment of work capacity and ... -
Epithelial signatures in respiratory disease
(2021-11-25)The epithelium of the human airways protects us against harm and helps maintain immune homeostasis. In respiratory diseases such as asthma and COPD, the functions of the epithelium are altered and can cause or contribute to ... -
The population burden of gout and urate in Western Sweden
(2021-11-02)Background: Gout is the most common type of inflammatory arthritis and is associated with several comorbidities and an increased risk of cardiovascular disease (CVD). However, data on the epidemiology and comorbidity ... -
Osteoporosis in murine SLE - Treatment with a tissue-selective estrogen complex
(2021-10)Systemic lupus erythematosus (SLE) is a chronic autoimmune disease affecting mainly young women. Almost every organ in the body can be affected and SLE patients often suffer from co-morbidities such as cardiovascular ... -
Mechanisms underlying inflammation, symptoms and quality of life in ulcerative colitis
(2021-10-06)A substantial proportion of patients with ulcerative colitis (UC) in remission demonstrate gastrointestinal (GI) symptoms, despite the absence of ongoing inflammation in the colon. The underlying mechanisms of these symptoms ... -
Adaptation of ventricular repolarization to heart rate change in humans
(2021-10-01)Background: Life-threatening cardiac rhythm disturbances and sudden death are common manifestations of heart disease. Disturbances in electrical recovery (ventricular repolarization; VR) are important mechanisms behind ... -
Predictors of survival in cardiac arrest
(2021-10-01)Cardiac arrest (CA) refers to the cessation of cardiac function. Survival is around 30% for in-hospital cardiac arrest (IHCA), and 10% for out-of-hospital cardiac arrest (OHCA). Many factors influence survival, ranging ... -
Cardiovascular morbidity and metabolic signature in patients with rheumatoid arthritis
(2021-09-09)Background and objectives: Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease with excess risk for cardiovascular morbidity and mortality. The treatment of RA by anti-inflammatory drugs has dramatically ...