Institute of Clinical Sciences / Institutionen för kliniska vetenskaper: Recent submissions
Visas titlar 281-300 av 582
-
Laparoscopic Lavage - A Paradigm Shift for the Treatment of Perforated Diverticulitis with Purulent Peritonitis?
(2015-11-13)Introduction: Perforated diverticulitis of the colon is a condition that sometimes requires surgical treatment. Traditionally Hartmann’s procedure is the recommended treatment. Laparoscopic lavage has lately evoked interest ... -
Intestinal adaption in response to Roux-en-Y gastric bypass surgery
(2015-11-12)ABSTRACT Background: Obesity is a condition with increasing prevalence that leads to morbidity, decreased quality of life and reduced life expectancy. The only effective evidence-based treatment is bariatric surgery. The ... -
Aspects on bleeding and transfusion in elective orthopaedic surgery. Clinical and experimental studies
(2015-11-11)Background: Perioperative bleeding complications are associated with increased morbidity and mortality. One way to minimize perioperative bleeding and transfusion is to identify patients at risk of bleeding. Preoperative ... -
Stress-induced cardiomyopathy - clinical and experimental studies
(2015-10-23)Background: Stress-induced cardiomyopathy (SIC) is an acute cardiac condition with akinesia in the left ventricle (LV) that can be severe. A stress-trigger, physical or emotional, is usually identified preceding onset of ... -
High-load injuries in the adolescent athlete's hip; clinical and experimental studies and outcome measures
(2015-10-08)The diagnosis and treatment of hip and groin symptoms has often been a problem area in orthopaedics and sports medicine. Hip and groin pain and injuries are common among athletes and in the increasingly active population. ... -
Biochemical and genetic markers after subarachnoid haemorrhage
(2015-09-28)ABSTRACT Background: Subarachnoid haemorrhage is a devastating disease with high morbidity and mortality despite novel treatment options are available. There are no established methods to measure the brain damage occurring ... -
Measurement of T1 relaxation time in lungs - Preclinical and clinical MRI applications to COPD
(2015-09-16)Monitoring of regional lung function in clinical trials of chronic obstructive pulmonary disease (COPD) requires alternative endpoints beyond global pulmonary function tests (PFTs), which is the most common approach for ... -
Molecular and structural patterns of guided bone regeneration (GBR). Experimental studies on the role of GBR membrane and bone substitute materials
(2015-09-15)The mechanisms of guided bone regeneration (GBR) and bone healing with calcium phosphate (CaP) bone substitutes are not fully understood. The major aim of this thesis was to determine the relationship between the bone ... -
Acetabular Revisions
(2015-09-15)Hip replacement is a successful intervention when treating patients with hip osteoarthritis. Approximately 10% of all patients undergoing primary hip replacement surgery require further surgical interventions (revisions) ... -
Pediatric Autoinflammatory Diseases: Conceptual, Clinical, and Mechanistic Dimensions
(2015-09-10)This thesis focuses on three paediatric autoinflammatory diseases in Sweden today; familial Mediterranean fever (FMF), periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) and synovitis, acne, ... -
Surgery versus nonsurgical treatment of cervical radiculopathy. Randomized studies of anterior cervical decompression and fusion followed by physiotherapy versus structured physiotherapy alone
(2015-09-10)Background and aims: Cervical radiculopathy (CR) is a symptom complex comprising neck pain and radiating arm pain due to compression of one or more cervical nerve roots, caused by spondylotic narrowing of the intervertebral ... -
Anterior cruciate ligament reconstruction: long-term outcome in adults and adolescents. Clinical results, health-related quality of life, radiographic findings and boone mineral assessments
(2015-09-10)The aim of this thesis was to measure health-related quality of life (HRQoL) and assess pre-operative factors predicting good outcome of HRQoL after anterior cruciate ligament (ACL) reconstruction. Furthermore, to specifically ... -
The regulatory role of osteoblasts in castration-resistant growth of prostate cancer
(2015-08-18)Bone metastasis of a predominantly osteoblastic (sclerotic) nature is the outcome for the vast majority of patients with castration-resistant prostate cancer (CRPC). Pathologically, osteoblastic tumors are characterized ... -
The Clinical Importance Of Anti-Endothelial Cell Antibodies In Chronic Kidney Dysfunction And Organ Transplantation
(2015-06-15)The endothelium is the thin layer of cells that lines the interior surface of blood vessels and is the first site of contact between immune cells and tissues. Therefore, alterations at the level of the endothelium are ... -
Electrosurgical plasma-mediated ablation for application in dermal wound and cartilage debridement - Biochemical, microbiological and clinical effects
(2015-05-22)The state of matter known as plasma has in the latest decades been investigated within different areas of medical treatment. The work presented in this thesis has focused on a specific type of plasma-based electrosurgical ... -
Children and adolescents with Type 1 Diabetes Mellitus: family dynamics and health-related quality of life after diabetes onset
(2015-05-21)ABSTRACT Aim: The main aim of this thesis was to explore different aspects of family dynamics and health- related quality of life (HRQOL) after the onset of T1DM in children and adolescents. A second aim was to ... -
Anterior cruciate ligament reconstruction using semitendinosus and gracilis autograft. Evaluation of the clinical outcome, radiographic findings, histology and biochemistry
(2015-05-18)The present thesis focuses on different aspects of anterior cruciate ligament (ACL) reconstruction using hamstring tendon (HT) autografts. In Study I, two groups of patients were compared. One group underwent surgery in ... -
Cerebral CT - and MRI perfusion: Techniques and clinical application in iNPH
(2015-05-18)Idiopathic normal pressure hydrocephalus (iNPH) is a disorder of the elderly, defined by slowly progressive impairment of gait and balance, cognitive decline, and incontinence. Disturbance of the cerebrospinal fluid (CSF) ... -
Epigenetic influence on cardiovascular protective mechanisms in vivo: explorations of t-PA release and extracellular vesicle genetic content
(2015-05-18)ABSTRACT Background: Ischemic heart disease is one of the leading causes of death globally. This thesis explores endogenous mechanisms protecting against myocardial ischemia in context of epigenetics (changes in gene ... -
On the role of surface properties for implant fixation : From finite element modeling to in vivo studies
(2015-05-13)The aim of this thesis was to gain a deeper understanding of the factors contributing to the fixation of bone-anchored implants, especially with regard to surface chemistry, surface topography and implant loading. The ...