Department of Chemistry and Molecular Biology / Institutionen för kemi och molekylärbiologi (2012-): Recent submissions
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Cell Membrane Homeostasis in Mammals - The roles of ADIPOR2 and TLCD1 & 2
(2022-05-04)Ten nanometers. That is the approximate thickness of the plasma membrane that separates the extracellular space from the entire cellular machinery. An asymmetrical bilayer consisting of predominantly phospholipids in which ... -
Towards 3D Covalent Organic Framework Films
(2022-05-03)Porous materials are of great scientific interest because they are able to interact with guests, such as ions, atoms and molecules throughout their entire volume. One big subgroup of organic porous materials are covalent ... -
Nitrogen-containing products from atmospheric oxidation of volatile organic compounds
(2022-03-15)Atmospheric oxidation of volatile organic compounds (VOC) produces a wide range of oxygenated organic products that lead to formation of secondary organic aerosol (SOA). SOA represents a significant fraction of the ... -
Laser Scanning Multiphoton Microscopy – Focusing on Fluorescence Correlation Spectroscopy and Fluorescence Lifetime Imaging for Biomedical Applications
(2022-03-02)Laser scanning multiphoton microscopy (MPM) is considered as a non-invasive technology for three-dimensional imaging of complex biological tissues. The quantitative potential of the MPM is not investigated as much as ... -
Excited state dynamics in the strong coupling regime
(2022-02-24)Strong exciton-photon coupling exhibits the possibility to modify photophysical and photochemical properties of organic molecules without changing their structure. This is due to the formation of hybrid light-matter states, ... -
Electromagnetic Field Induced Out-of-Equilibrium Structural Dynamics in Protein Crystals: From Picoseconds to Milliseconds
(2022-02-04)Light-induced interactions in biomolecules are strongly varying over different model systems. Most amino acids and proteins absorb ultraviolet light, but only a few with specialised chromophores or fluorophores, are able ... -
The Structural Modularity and Inherent Dynamics of the DegP Protease together with its Intertwined Role in the Bacterial Periplasm
(2021-12-09)The protein quality control machinery is a delicate and integrated network of molecular tools working together to fold or remove unwanted proteins from the cell. A distinct set of “gatekeepers” are involved in this process ... -
Water Condensation and Freezing in the Atmosphere: Exploring Deliquescence and Ice Nucleation
(2021-11-25)Atmospheric aerosols play key roles in numerous atmospheric processes. They affect human health, are substrates and components for atmospheric chemistry, and via their contribution to clouds affect the water cycle and the ... -
The molecular chaperone CCT: Functions beyond folding
(2021-10-07)The chaperonin-containing tailless complex polypeptide 1 (CCT) is a eukaryotic ~1 MDa barrel shaped molecular chaperone, built up by eight distinct subunits and is required for the folding of the abundant cytoskeletal ... -
Using Light to Regulate the Activity of RET Kinase: Design, synthesis and evaluation of photoswitchable DFG-out RET kinase inhibitors
(2021-08-26)Protein kinases are essential for signal transduction and regulate most cellular processes, such as metabolism, membrane transport, motility, and cell cycle. Although they play a critical role in cells and have a strong ... -
Investigation of Exocytosis for a New Paradigm of Plasticity in Biological Systems Using Electrochemistry and Mass Spectrometry Imaging
(2021-05-05)Cellular communication is a vital process and serves as the basis for complex brain functions in multicellular organisms. The majority of cellular communication is achieved via the release of specific signaling molecules, ... -
LOOK AROUND, WHAT CAN YOU DISCOVER? The science center - a critical space for science student teachers’ development
(2021-04-21)This thesis aims to examine the opportunities and constraints on student teachers’ learning of science and teaching science when they work in small groups; planning, implementing, and reflecting upon teaching at the ... -
Reverse structural biology: Cellular processes uncovered by electron microscopy
(2021-03-25)This thesis contains two projects, both using electron microscopy as the primary technique. In the first project, nuclear envelope budding (NEB) is investigated as an alternate method of transport across the nuclear ... -
Identification of novel BRCA2-binding proteins that are essential for meiotic homologous recombination
(2021-01-27)Meiotic recombination is a molecular process in which the induction and repair of programmed DNA double-strand breaks (DSBs) creates genetic exchange between homologous chromosomes and thus increases genetic diversity and ... -
Revealing the architecture and composition of the sperm flagellum tip
(2021-01-25)The eukaryotic flagellum is a membrane-bound protruding organelle with a cytoskeleton of microtubules. Flagella are found in unicellular as well as multicellular organisms, performing a variety of functions. Motile flagella ... -
Lipidic Cubic Phase Microcrystallization and its Application in Serial Crystallography
(2020-10-23)Every living organism contain a cell membrane which is an important cell structure with a vast variety of different functions such as cell signaling, transportation and energy production. One of the most important functions ... -
A Holistic View on Aquaporins: Production, Structure, Function and Interactions
(2020-10-21)Aquaporins are specialised membrane proteins, which regulate the water homeostasis of cells. In eukaryotic organisms, this process is tightly regulated, and aberrations in aquaporin functionality lead to severe pathologies ... -
Membrane Fluidity Regulation: From C. elegans to mammalian cells
(2020-08-12)Biological membranes are primarily an assembly of lipids and proteins. Collectively, these constituents within a phospholipid bilayer determine the physical membrane properties such as fluidity, viscosity, thickness, packing ... -
Preharvest Conditions Affecting Apple Quality, Antioxidant Responses and Susceptibility to the Infection by Grey mould (Botrytis cinerea)
(2020-05-20)Apple fruits are rich in vitamin C and other antioxidants, which are beneficial for human health. During postharvest storage, there are losses as a result of diseases such as grey mould, caused by the fungus Botrytis ... -
Quantum dynamical effects in complex chemical systems
(2020-05-12)When using mathematical models to computationally investigate a chemical system it is important that the methods used are accurate enough to account for the relevant properties of the system and at the same time simple ...