Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper: Recent submissions
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Promoting the Clinical Relevance of 3D Bioprinting
(2022-02-03)This thesis focuses on the development of methodologies enabling the reconstruction of autologous, functional, and long-term-stable cartilage-like tissue using 3D bioprinting technology and animal experiments. The stability, ... -
Pelvic floor dysfunction in nulliparous women
(2022-01-18)Background: Pelvic floor dysfunction (PFD) is a public health problem affecting millions of women worldwide. In addition to personal suffering, it also creates an economic burden for health care systems and society. Parity ... -
Bioabsorbable Screws for Pelvic Osteotomies in Children
(2022-01-07)Multiple conditions, with developmental dysplasia of the hip being a prime example, affect the congruity of the pediatric hip joint. A Salter osteotomy (SO) or a triple pelvic osteotomy (TPO) can be used to address suboptimal ... -
On the biological behavior of barrier membranes: implications for Guided Bone Regeneration. Clinical and Experimental studies
(2021-12-21)There is a continuous development of bone augmentation solutions to meet the rising demand for effective dental implant rehabilitations. One of the most used techniques is Guided Bone Regeneration (GBR). Although successful ... -
The roles of osteoclasts and RUNX2 in the progression of prostate cancer bone metastases
(2021-11-23)Metastasis to the skeleton is the major cause of death from prostate cancer (PC). Patients with metastatic PC are treated with androgen deprivation therapy (ADT) to decrease testosterone levels and thereby inhibit further ... -
Lumbar Disc Herniation Surgery - Novel Approaches, Timing and Outcomes
(2021-11-16)Lumbar Disc Herniation Surgery – Novel Approaches, Timing and Outcomes JOEL BECK Department of Orthopaedics, Institute of clinical sciences, Sahlgrenska academy, University of Gothenburg, Sweden, 2021 ABSTRACT BACKGROUND ... -
Breast cancer surgery - Aspects of patient-reported outcomes and physical activity
(2021-11-15)The aim of this thesis was to evaluate patient-reported outcomes (PROs) following breast cancer surgery using three different studies. Paper I examined breast-conserving surgery through an inframammary fold incision using ... -
Jejunal control of glucose homeostasis in the human body
(2021-11-15)Background: The prevalence of obesity and type-2 diabetes mellitus (T2DM) have risen dramatically over the last decades, and are major threats to the human health. Obesity, and also T2DM, is treated with lifestyle ... -
Sagittal synostosis - surgical outcomes and long-term follow up
(2021-11-11)The overall aim of this thesis was to evaluate and compare surgical outcomes in patients with sagittal synostosis operated with the most commonly used surgical methods in Sweden: craniotomy combined with springs, pi-plasty, ... -
Experiences of living with cleft lip and palate - a gender perspective
(2021-11-10)The primary aim of this thesis was to investigate the influence of gender on the CL/P population with regard to treatment, self-reported appearance, psychosocial adjustment, and subjective experiences. Study I, a retrospective ... -
Running-related injuries in recreational athletes.
(2021-11-09)Running as a form of physical activity continues to grow in popularity and is accompanied by a number of health benefits, but one of the greatest threats that challenge these benefits is running-related injuries. The overall ... -
Vaccine-induced aluminium allergy and long-lasting subcutaneous itching nodules
(2021-11-09)Background: Aluminium contact dermatitis is rare even though aluminium is frequently used in antiperspirants and sunscreens. Sensitisation to aluminium is mostly a side effect of aluminium-adsorbed vaccines. These can ... -
Spinal column and hip joint changes, and their correlation to back pain in young athletes - Radiological and Clinical Studies
(2021-10-29)Background: Young athletes are at increasing risk for spinal column injuries and back pain due to excessive sporting activities, with potential development of complications ... -
Signaling pathways and novel genetic factors involved in modulation of cisplatin response in C. elegans
(2021-10-29)Cancer is a major cause of mortality throughout the world. Despite the effort of the scientific community, plenty remains to understand about the biology or genetics of cancer. In solid tumors often as many as 90-99% of ... -
Towards a balanced radiotherapy workflow using practical solutions identified by field studies and simulations
(2021-10-26)With increasing cancer incidence comes a higher demand for radiotherapy (RT). Resources available for RT, well-educated staff, and linear accelerators (linacs), are limited. To meet the increasing demand without violating ... -
Obesity, weight reduction treatment and IVF
(2021-10-26)Background: Obesity is a growing problem on a global scale and women with obesity have a higher risk for infertility and complications, for both mother and child, in pregnancy and birth. This has been shown both regarding ... -
Sex steroid secretion during childhood in males - with focus on prematurity, birth size, and growth patterns
(2021-10-21)Aim: The overall aim of the thesis was to evaluate sex steroid secretion patterns during childhood in boys and to study how sex steroid concentrations relate to gestational age, birth weight, growth patterns, and adult ... -
Aspects of Chemotherapy in Prostate Cancer
(2021-10-19)Since 2004 chemotherapy has been a part of standard of care in prostate cancer (PC) and improved symptom control and survival has been demonstrated in metastatic castration-resistant PC. Whether docetaxel has benefits in ... -
Humeral fractures - Epidemiology, treatment and reoperations in the Swedish Fracture Register
(2021-10-15)Fractures are common, but the knowledge on outcomes, treatment methods or the actual number of fractures treated each year has been sparse. With the introduction of the Swedish Fracture Register (SFR) in 2011, the prospective ... -
Periarticular changes in association with osteoarthritis in the hip, knee or shoulder
(2021-10-08)The aim of this thesis was to evaluate the presence of degenerative changes in the periarticular tendons in association with osteoarthritis (OA) in the hip, knee or shoulder. Moreover, changes in bone mineral density (BMD) ...