Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper: Recent submissions
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Treatment of early prostate cancer - reducing side effects without jeopardizing cure
(2021-09-29)The overall aim of this thesis is to gain further knowledge of how surgical choices affect the outcome for patients undergoing radical prostatectomy for early prostate cancer including preoperative evaluation and long-term ... -
lntrafractional motion effects during stereotactic body radiation therapy of lung tumors
(2021-09-24)Abstract: Patient shifts and tumor motions occurring during stereotactic body radiation therapy (SBRT) have been analyzed to determine the related effects on the delivered dose. Methods: 4-dimensional computed tomography ... -
Vitamin D and Vitamin D-binding Protein in Psoriasis and Effects of Treatment
(2021-09-16)Background: Topical vitamin D analogues constitute an established treatment for psoriasis but the role of vitamin D in the pathogenesis of the disease remains controversial. The in loco production and immunomodulatory ... -
Aspects of bone quality and risk assessments in fracture and elective orthopaedic patients
(2021-09-15)Background: Bone quality, bone strength, and bone remodelling are important in many orthopaedic conditions and can have an impact on fracture incidence, bone healing, implant failure, and different outcome aspects. ... -
Cardiac arrest - an epidemiologic perspective on pharmacotherapy and post resuscitation care
(2021-09-13)Background: Despite significant research and progress, cardiac arrest remains a condition with a high mortality rate, and few interventions have been demonstrated to improve outcomes in this patient group. Despite incorporation ... -
Changes in prevalence of asthma and allergy in Swedish school children over almost three decades and factors reducing risk of allergy
(2021-09-01)ABSTRACT Background: Asthma and allergy are one of the most common chronic diseases among children. The prevalence of allergic diseases increased dramatically during the last decades of the twentieth century. The reason ... -
Neonatal invasive infections with focus on Group B streptococci
(2021-08-18)Invasive infections affect neonates with the risk of severe morbidity and death, and Streptococcus agalactiae (Group B streptococcus, GBS) remains one of the most common pathogens. The aim of this thesis was to assess ... -
Femoroacetabular impingement syndrome. Trends and outcomes after arthroscopic treatment in the general and athlete population
(2021-08-18)Femoroacetabular impingement syndrome (FAIS) is a common cause of hip pain in the young and athletic population. The diagnosis - FAIS - is based on a triad of symptoms, clinical evaluation and radiographic signs. The ... -
Principles of scaffold generation for bioengineering of the ovary and uterus: a study focusing on decellularization
(2021-05-27)Introduction: Cancer therapy often result in fertility problems due to inflicted injury to the reproductive organs. Since most women survive cancer, fertility preservation has become an important consideration during cancer ... -
On osseointegration in response to controlled surface nanotopography
(2021-05-20)Knowledge about the biological responses provoked by the surface modification of titanium implants on the nanoscale is still in its infancy. Although in vitro studies claim superior effects considering higher adhesion and ... -
Orthogeriatric anaesthesia - studies on the bone cement implantation syndrome, risk prediction and intraoperative haemodynamics
(2021-05-17)The bone cementation implantation syndrome (BCIS), as seen in orthopaedic patients, is characterised by intraoperative hypotension and hypoxia and loss of consciousness around the time of bone cementation. In a retrospective ... -
Blood pressure-dependent changes in plasma volume, glycocalyx and platelet function during anaesthesia -Clinical and experimental studies
(2021-05-11)Background: Worldwide, more than 300 million surgeries are performed each year. General anaesthesia provides the surgical patient with a state of controlled loss of sensation and awareness. It is common that general ... -
Translational and clinical aspects of pancreatic cancer
(2021-05-10)Pancreatic cancer is a disease with dismal prognosis due to late detection and ineffective treatments. The majority of the patients already have disseminated disease at the time of diagnosis. The only potential curative ... -
Optimized use of MRI in a PSA based prostate cancer screening program
(2021-05-07)The overall aim of this thesis was to optimize different aspects of the use of MRI in screening for prostate cancer. Paper 1 was based on preoperative MRI in a prostatectomy cohort. Papers 2-4 were based on data from the ... -
Methodological considerations in epidemiological studies in perinatal medicine
(2021-05-05)This thesis is based on two projects, each consisting of two papers. In these two projects we investigated factors affecting the variability in gestational duration, and associations between maternal diet and neonatal ... -
Transurethral microwave thermotherapy and transurethral resection of the prostate. Evaluation and development.
(2021-04-29)ABSTRACT Lower urinary tract symptoms (LUTS) are common among men and become more prevalent with increasing age. One frequent cause is benign prostatic obstruction (BPO). Patients with LUTS/BPO can be ameliorated if the ... -
Magnetic Resonance Imaging as a Screening Tool for Prostate Cancer
(2021-04-20)The overall aim of this thesis was to explore the role of Magnetic resonance imaging (MRI) of the prostate as an adjunct to the prostate-specific antigen (PSA)-test in screening for prostate cancer (PCa), focusing on the ... -
Robotic Surgery for Endometrial Cancer
(2021-04-16)Endometrial cancer (EC) is the most common gynecological malignancy. A large proportion of patients present with the risk factors high age and obesity, which puts them at increased risk when undergoing surgery. The last ... -
Cell Therapy in lntervertebral Disc Degeneration
(2021-04-12)Background: Chronic low back pain (LBP) is the leading cause of disability worldwide. Intervertebral disc degeneration (IDD) is central in the pathogenesis. The injection of bone marrow-derived mesenchymal stromal cells ... -
Young adults with childhood-onset inflammatory bowel disease - aspects of bone mineral density, body composition and physical exercise
(2021-04-07)Background: Our research group has previously shown that low bone mineral density (BMD) is common in children and adolescents with inflammatory bowel disease (IBD). However, there is limited knowledge on the development ...