Doctoral Theses from Sahlgrenska Academy: Recent submissions
Now showing items 221-240 of 2013
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Epidemiology of viral respiratory infections with focus on in-hospital influenza transmission
(2020-05-18)Human Rhinoviruses (HRV) and influenza viruses are respiratory pathogens which represent a major global disease burden. Healthcare-associated infections (HCAI) are increasingly recognized as a public health concern, but ... -
Biomarkers in mid-trimester amniotic fluid in relation to gestational duration and spontaneous preterm delivery
(2020-05-15)Background: The biological mechanisms and physiological pathways of pregnancy maintenance and timing of delivery are complex and multifactorial. Pregnancy clocks, partly controlled by timing mechanisms linked to fetal ... -
Internationally adopted children with unilateral cleft lip and palate - longitudinal perspectives on speech production and language ability
(2020-05-13)Many children with cleft lip and palate have been adopted to Sweden. Most had had no palatal closure performed in their native countries and received their first palatal surgery in Sweden while acquiring a new first language. ... -
Identification of novel antibiotic resistance genes through the exploration of mobile genetic elements
(2020-05-12)Backgrounds and aims: The evolution of multi-resistant pathogens is seriously threatening our ability to provide modern healthcare. Many of the mobile resistance factors in clinics appear to originate from environmental ... -
On tissue engineering of pig, human, and non-human primate tissues
(2020-05-07)Background: Demand for donor organs for transplantation has been increasing every year more than the actual supply of suitable donor organs. One of the major problems associated with allogeneic transplantation includes ... -
Cardiac arrest with emphasis on comorbidity and choice of treatment in acute coronary syndrome in the elderly
(2020-05-07)Background and aim: More data is required on survival and neurological outcome after in-hospital cardiac arrest (IHCA) in the elderly. The influence of comorbidity is often neglected in cardiac arrest research, particularly ... -
Primordial radionuclides in pit lakes in Sweden
(2020-05-07)In Sweden, there are many pit lakes, originating from limestone quarries and metal mines, with unknown status in regard to the activity concentration of radionuclides. Such knowledge is generally available only for pit ... -
Natural course and long-term prognosis in idiopathic Normal Pressure Hydrocephalus - the effect of delayed surgery and clinical factors on outcome and survival
(2020-05-07)Idiopathic Normal Pressure Hydrocephalus, iNPH, causes gait and balance difficulties, urinary incontinence and cognitive decline in mainly older persons and is treatable by insertion of a cerebrospinal fluid diverting ... -
Recurrent infection with Extended-Spectrum Beta-Lactamase (ESBL) -producing Enterobacteriaceae
(2020-05-05)Infections with Extended-Spectrum Beta-Lactamase (ESBL)-producing Enterobacteriaceae (EPE) are increasing globally. The most common EPE are the gut pathogens Escherichia coli (ESBL-E. coli) and Klebsiella pneumoniae (ESBL-K. ... -
Development and dynamics of the normal gut microbiota
(2020-05-05)Altered gut microbiota configurations have been linked to human diseases. To identify mechanistic links between altered gut microbiota and disease states, definitions of the healthy gut microbiota need to be established. ... -
Understanding the molecular mechanisms of bile acid receptor activation for the treatment of human liver disease
(2020-04-30)Farnesoid X receptor (FXR) is a nuclear transcription factor that is activated by bile acids and regulates bile acid homeostasis, glucose and lipid metabolism. FXR activation by a ligand has been identified as a therapeutic ... -
Decellularization as a method to generate a new generation of vascular grafts
(2020-04-29)Decellularization of blood vessels is a technique to remove cells from the extracellular matrix (ECM), which can be used as a vascular graft for peripheral or coronary blood vessel bypass surgery. This thesis focuses on ... -
Release and Clearance Mechanisms of Cardiac Troponin
(2020-04-28)Myocardial infarction (MI) is often suspected when a patient presents with chest pain. MI is defined as cardiac necrosis due to ischemia, most often mediated through impaired coronary perfusion. Cardiac necrosis results ... -
Virtual reality based kinematics for assessment of post-stroke upper limb function
(2020-04-28)The main scope of this thesis was to develop a method for assessing the upper limb sensorimotor function following stroke using virtual reality-based technique. The studies reported in this thesis included 67 individuals ... -
Depression among Swedish 70-year-olds - Sex differences from a gender perspective
(2020-04-28)Depression is one of the leading causes of global burden of disease. Due to increased life expectancy, late-life depression is an escalating public health issue. The prevalence is reported to be almost twice as high among ... -
Congenital Heart Disease, Type 1 and Type 2 Diabetes Mellitus
(2020-04-28)Worldwide, 1% of all live born children are born with a congenital heart disease (CHD) and currently >95% reach adulthood due to better diagnostics and medical care. At the same time, Diabetes Mellitus (DM), type 1 (T1DM) ... -
Investigating the role of Class-1 Phosphoinositide 3 Kinases (PI3Ks) in insulin signaling and obesity
(2020-04-28)Obesity and obesity related diseases such as type 2 diabetes, cardiovascular disorders, and different types of cancer are leading causes of mortality and morbidity in modern society. However, the mechanism that links obesity ... -
Impact of Genetic Variants in Inosine Triphosphate Pyrophosphatase and Interferon-λ4 on Natural History, Treatment Response and Ribavirin Pharmacology in Hepatitis C Virus Infection
(2020-04-23)Hepatitis C virus (HCV) impacts on global health with around 70 million chronically infected worldwide. The infection increases the risk of cirrhosis and primary liver cancer. The treatment until 2013 has been based on ... -
On Aging, Behavior and the Role of PA28αβ in Protein Homeostasis
(2020-04-23)As life expectancy increases, understanding challenges related to the processes of aging are more relevant than ever. Common age-related diseases progress as consequences of accumulative protein damage and protein aggregates. ... -
Cardiovascular disease in patients with congenital heart disease
(2020-04-23)Background: Today, about 95% of children with congenital heart disease (CHD) survive into adulthood and the survival in patients with CHD has increased considerably during the last decades. With increasing age, patients ...