Doctoral Theses from Sahlgrenska Academy: Recent submissions
Visas titlar 201-220 av 2013
-
Pathophysiology and treatment of Takotsubo Syndrome - insights from preclinical studies
(2020-09-03)ABSTRACT Background: Takotsubo syndrome (TTS), also recognized as “stress-induced cardiomyopathy (SIC)” and “broken heart syndrome”, is an acute cardiac failure syndrome characterized by transient regional ventricular ... -
Appetite-regulating peptides and natural rewards: emphasis on ghrelin and glucagon-like peptide-1
(2020-09-02)Evolutionary conserved natural behaviors, such as foraging and sexual behaviors, are strongly associated with reward processes. Brain areas important for reward processes include, but are not limited to, the nucleus accumbens ... -
Population-based studies of brain tumor surgery: surgical outcome and prognostic factors
(2020-08-27)Neurosurgery is the cornerstone in the treatment of a majority of brain tumors. Surgery can sometimes cure or delay tumor progression. However, surgery is associated with risks, and adequate information about the anticipated ... -
Diagnostic aspects of skin cancer and lichen sclerosus studied with laser scanning microscopy
(2020-08-20)Histopathologic examination of tissue biopsies is the current gold standard for the diagnosis of dermatological problems. Similarly, in oncology, sentinel lymph node (SLN) biopsy is the state-of-the-art diagnostic method ... -
Predicting mortality by comorbidity for patients with hip arthroplasty: Prospective observational register studies of a nationwide Swedish cohort
(2020-08-19)INTRODUCTION: Patients with total hip arthroplasty (THA) due to osteoarthritis (OA) are usually healthy, some with a remaining lifetime of several decades after surgery. Patients with hip arthroplasty due to a femoral ... -
Optimizing postoperative radiation therapy in prostate cancer: focus on side-effects, practical implementation and dose distribution
(2020-08-18)Optimizing postoperative radiotherapy in prostate cancer: focus on side effects, practical implementation and dose distribution Karin Braide, MD Department of Urology, Institute of Clincal Sciences Sahlgrenska Academy, ... -
The fight against time in prehospital cardiac arrest - a true medical emergency
(2020-08-18)ABSTRACT Background: The chances of survival after an out-of-hospital cardiac arrest (OHCA) are one in ten. The majority of survivors have no or relatively mild neurological sequelae. Interventions are time critical and ... -
Paracrine control of glucagon secretion in the pancreatic α-cell: Studies involving optogenetic cell activation
(2020-06-12)ABSTRACT The mechanisms controlling glucagon secretion by α-cells in islets of Langerhans were studied. We generated mice with the light-activated ion channel ChR2 specifically expressed in β-, α-, and δ-cells, and ... -
A Podocyte view on RhoGTPases and actin cytoskeleton regulation
(2020-06-11)Proteinuria is a hallmark symptom of chronic kidney disease, that if left to persist constitutes a risk for progression of disease. Symptomatic treatment aiming at decreasing proteinuria is therefore standard practice. ... -
Recombinant mucin-type proteins as tools for studies on the interactions between Helicobacter pylori and its carbohydrate receptors
(2020-06-11)Glycan-protein interactions are important in pathogen adhesion and infections. H. pylori has adhesins which enables it to bind to glycans on the gastric mucosa and, in the long run, cause gastric cancer. The reported current ... -
Comprehending the Comprehensive Geriatric Assessment. Feasibility, outcomes and experiences of frail older people
(2020-06-04)ABSTRACT Despite existing knowledge on how to approach frail people in health care, the care they receive is commonly not designed to meet their complex needs and support them in maintaining their activities of daily ... -
On Cyclodeviation - Strategies for Investigation, Management and quality of Life
(2020-06-04)Introduction: Cyclodeviation is a form of strabismus that is not externally visible. It is measured subjectively and in degrees, as incyclotorsion or excyclotorsion. The perception of subjective tilting does not always ... -
Aspects on the use of slowly degradable mesh in inguinal hernia surgery
(2020-06-04)Background: Synthetic non-degradable mesh used in inguinal hernia surgery can cause chronic inflammation, which in turn can lead to chronic post-operative pain (CPP). Theoretically, a degradable mesh could reduce the risk ... -
Obesity, Weight Loss and Cardiovascular Risk
(2020-05-26)Background: The global prevalence of obesity is on the rise, contributing to increased incidence and prevalence of cardiovascular morbidity and mortality. Obesity has adverse effects on cardiac structure and function, ... -
The impact of signaling factors on intervertebral disc degeneration and regeneration - studies on disc and mesenchymal stem cells from chronic low back pain patients
(2020-05-19)INTRODUCTION: Chronic low back pain (LBP) is associated with degeneration of the intervertebral discs (IVDs). Increased expressions of pro-inflammatory cytokines such as interleukin-1β (IL-1β) and matrix metalloproteinases ... -
Aspects of infection and leukemia in Rwanda
(2020-05-19)A first part of this thesis addressed the potential impact of variants of genes encoding interferon-λ4, which is a cytokine that participates in protection against pathogens at epithelial surfaces, for the resolution of ... -
Shedding light on cognitive control
(2020-05-18)This thesis aimed to investigate the ability to adjust cognitive processes and behavior, i.e., cognitive control, and its related functional activity in the cortex. The optical imaging technique functional near-infrared ... -
On translucent yttria stabilized zirconia ceramics: Mechanical considerations, phase transformation and cement choices
(2020-05-18)New zirconia formulations (4Y and 5Y-zirconias) have been introduced for prosthodontic therapy and are commercialized as “translucent” zirconias. No clinical information providing their survival rates or complications has ... -
Development of MALDI Mass Spectrometry Imaging Methods for Probing Spatial Lipid Biochemistry of Amyloid Plaques in Alzheimer's Disease
(2020-05-18)Alzheimer’s disease (AD) is the most prevalent cause of neurodegenerative dementia. Aggregation of amyloid β (Aβ) peptides into extracellular Aβ plaques is one of the major neuropathological features of AD. However, Aloysius ... -
The effect of intra-abdominal local anaesthetics following major gynaecological surgery. Clinical and experimental studies
(2020-05-18)Background: Local anaesthetics (LA), in addition to inhibition of pain signalling, also have anti-inflammatory properties. In vitro studies have demonstrated anti-proliferative and cytotoxic effect of LAs on cancer cells ...