Doctoral Theses from Sahlgrenska Academy: Recent submissions
Now showing items 61-80 of 1888
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Cardiac arrest - an epidemiologic perspective on pharmacotherapy and post resuscitation care
(2021-09-13)Background: Despite significant research and progress, cardiac arrest remains a condition with a high mortality rate, and few interventions have been demonstrated to improve outcomes in this patient group. Despite incorporation ... -
Cardiovascular morbidity and metabolic signature in patients with rheumatoid arthritis
(2021-09-09)Background and objectives: Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease with excess risk for cardiovascular morbidity and mortality. The treatment of RA by anti-inflammatory drugs has dramatically ... -
On the efficacy and prescription of serotonin reuptake inhibitors
(2021-09-09)This thesis addresses several controversial issues regarding commonly used antidepressants, including selective serotonin reuptake inhibitors (SSRIs), serotonin and noradrenaline reuptake inhibitors (SNRIs), and tricyclic ... -
Root Canal Treatment in a Swedish Public Dental Service - Studies of indications and results
(2021-09-09)Despite the marked overall improvement of oral health in Sweden, root canal treatment is still a common procedure in general dental practice. The reasons are unclear. Few studies of root canal treatment have been undertaken ... -
Changes in prevalence of asthma and allergy in Swedish school children over almost three decades and factors reducing risk of allergy
(2021-09-01)ABSTRACT Background: Asthma and allergy are one of the most common chronic diseases among children. The prevalence of allergic diseases increased dramatically during the last decades of the twentieth century. The reason ... -
The role of glycoproteins in glomerular pathophysiology
(2021-09-01)Chronic kidney disease (CKD) is increasing worldwide and has a prevalence of around 10%. With time patients are at risk of losing their renal function and will need dialysis or transplantation for survival. There are no ... -
Cancer in organ transplant recipients
(2021-08-27)Tens of thousands of transplantations are performed around the world each year. Organ transplant recipients (OTR) are obliged to receive life-long medical treatment with immunosuppressive drugs to ensure graft function. ... -
Neonatal invasive infections with focus on Group B streptococci
(2021-08-18)Invasive infections affect neonates with the risk of severe morbidity and death, and Streptococcus agalactiae (Group B streptococcus, GBS) remains one of the most common pathogens. The aim of this thesis was to assess ... -
The medical perspective in prescribing: measurements and educational strategies
(2021-08-18)Background and aims: Drug treatment is a keystone in modern healthcare and for safe prescribing of drugs, an overall medical perspective has to be applied, taking patient characteristics into account. For each medication, ... -
The impact of the progranulin-sortilin axis on breast cancer stem cell activity and patient outcome
(2021-08-18)Breast cancer is the most common cancer in women worldwide. Still today, despite current breast cancer therapies, many patients experience treatment resistance and relapse, which are believed to be due to failure in targeting ... -
Femoroacetabular impingement syndrome. Trends and outcomes after arthroscopic treatment in the general and athlete population
(2021-08-18)Femoroacetabular impingement syndrome (FAIS) is a common cause of hip pain in the young and athletic population. The diagnosis - FAIS - is based on a triad of symptoms, clinical evaluation and radiographic signs. The ... -
T cells and chemokines in rheumatoid arthritis
(2021-08-18)In this thesis, we investigated if circulating proportions of specific CD4+ T cell subsets and blood chemokine levels were associated with disease activity and/or could predict remission in patients with early ... -
Defense-related inhibition of sympathetic nerve activity: Insights from neuroimaging and monozygotic twins on related cortical processes and clinical potential
(2021-05-27)This thesis investigates a physiological phenomenon observed in the peripheral sympathetic nervous system in response to various stressors and tries to bring it closer to clinical research. Sudden surprising stimulation ... -
Principles of scaffold generation for bioengineering of the ovary and uterus: a study focusing on decellularization
(2021-05-27)Introduction: Cancer therapy often result in fertility problems due to inflicted injury to the reproductive organs. Since most women survive cancer, fertility preservation has become an important consideration during cancer ... -
Pan-cancer study of transcriptional responses to oncogenic somatic mutations
(2021-05-27)Cancer cells typically carry acquired somatic mutations in key cancer driver genes, which can be identified on the basis of recurrence in cancer cohorts. Such mutations may cause aberrant protein activity and altered gene ... -
Measuring outcomes following brain tumor surgery: a registry based approach
(2021-05-27)Meningiomas and vestibular schwannomas (VS) are generally slow-growing and benign brain tumors, with low rates of tumor-related mortality. Surgery is rarely the only viable treatment option. In cases where there is no clear ... -
Intestinal transplantation: Outcome, complications and diagnostic approach
(2021-05-27)Background: Intestinal transplantation is a potentially lifesaving procedure conducted in candidates with e.g. intestinal failure. However, a limiting factor has been the complications, which are inherent to the procedure, ... -
Effects of an intervention and an organisational implementation for identification and treatment of common mental disorders in primary healthcare
(2021-05-26)Aim: This thesis aimed to evaluate the effects of one intervention and one organisational implementation for identification and treatment of common mental disorders (CMDs) in the primary healthcare in Region Västra Götaland, ... -
Alphaherpesvirus infections of the central nervous system – Biomarkers, diagnostics and antiviral therapy
(2021-05-25)Abstract Herpesviruses predate the evolution of humans and are globally ubiquitous. Herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2), and varicella-zoster virus (VZV) establish latency in neuronal ... -
The role of wastewater in surveillance and emergence of antibiotic resistant bacteria
(2021-05-25)As antibiotic resistance spreads among bacterial pathogens, it reduces treatment options and increases treatment failures of infectious diseases. Strategies employed to reduce this spread or adapt to its consequences ...