Doctoral Theses from Sahlgrenska Academy: Recent submissions
Now showing items 81-100 of 2013
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Measuring outcomes following brain tumor surgery: a registry based approach
(2021-05-27)Meningiomas and vestibular schwannomas (VS) are generally slow-growing and benign brain tumors, with low rates of tumor-related mortality. Surgery is rarely the only viable treatment option. In cases where there is no clear ... -
Intestinal transplantation: Outcome, complications and diagnostic approach
(2021-05-27)Background: Intestinal transplantation is a potentially lifesaving procedure conducted in candidates with e.g. intestinal failure. However, a limiting factor has been the complications, which are inherent to the procedure, ... -
Effects of an intervention and an organisational implementation for identification and treatment of common mental disorders in primary healthcare
(2021-05-26)Aim: This thesis aimed to evaluate the effects of one intervention and one organisational implementation for identification and treatment of common mental disorders (CMDs) in the primary healthcare in Region Västra Götaland, ... -
Alphaherpesvirus infections of the central nervous system – Biomarkers, diagnostics and antiviral therapy
(2021-05-25)Abstract Herpesviruses predate the evolution of humans and are globally ubiquitous. Herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2), and varicella-zoster virus (VZV) establish latency in neuronal ... -
The role of wastewater in surveillance and emergence of antibiotic resistant bacteria
(2021-05-25)As antibiotic resistance spreads among bacterial pathogens, it reduces treatment options and increases treatment failures of infectious diseases. Strategies employed to reduce this spread or adapt to its consequences ... -
Lipoproteins in the postprandial state: Studies on the metabolism of triglyceride-rich lipoproteins using multicompartmental models
(2021-05-21)Lipoproteins are lipid-containing spherical particles that circulate in the human blood stream. The reason for their intense study over the decades is their ability to cause atherosclerosis1. Atherosclerotic cardiovascular ... -
Ribonucleotides in DNA - Application in genome-wide DNA polymerase tracking and physiological role in eukaryotes
(2021-05-20)The genetic code in the eukaryotic cell is stored in the form of DNA, which is more resistant to hydrolysis than RNA. Replication fidelity and DNA repair mechanisms are in place to ensure genomic integrity to preserve the ... -
On osseointegration in response to controlled surface nanotopography
(2021-05-20)Knowledge about the biological responses provoked by the surface modification of titanium implants on the nanoscale is still in its infancy. Although in vitro studies claim superior effects considering higher adhesion and ... -
ACT for behaviour change in adults with poor oral health
(2021-05-19)The aim of this thesis is to contribute to the knowledge about psychological methods for behaviour change in adults with poor oral health. Study I is a systematic review of behavioural interventions for individuals ( 13 ... -
Clinical aspects of Arteriovenous fistula use in a haemodialysis population. Results based on retrospective and internventional studies.
(2021-05-19)When a patient suffers from end stage renal disease, the vascular access becomes the lifeline to perform regular haemodialysis (HD) treatment. The recommended first choice is the surgically created native Arteriovenous ... -
On the Origins of mobile Antibiotic Resistance Genes
(2021-05-17)Mobile antibiotic resistance genes (ARGs), transferable between bacterial cells, are major contributors to the antibiotic resistance crisis we are facing today. From which organisms pathogens acquired these genes is ... -
Orthogeriatric anaesthesia - studies on the bone cement implantation syndrome, risk prediction and intraoperative haemodynamics
(2021-05-17)The bone cementation implantation syndrome (BCIS), as seen in orthopaedic patients, is characterised by intraoperative hypotension and hypoxia and loss of consciousness around the time of bone cementation. In a retrospective ... -
Candidate biomarkers for synaptic pathology: neurogranin, neuroligins and neurexins in neurodegenerative disorders
(2021-05-14)Synapses are small units through which neurons communicate in the brain. They represent the site of memory formation and cognitive abilities and are thus primarily affected by neurodegenerative diseases such as Alzheimer’s ... -
Risk factors for dementia. Lifestyle, hormones, neurochemistry, and genetics
(2021-05-12)Objective: The aim of this thesis was to expand the understanding about the effects of lifestyle factors, indicators of endogenous estrogens, and genetic factors on the risk of dementia and cerebrospinal fluid (CSF) markers ... -
The Force of Blood
(2021-05-12)Aim: The overarching aim of this thesis was to investigate the prevalence, temporal trends and associations to cardiovascular outcomes of blood pressure levels in patients in Västra Götaland. Methods and findings: In Study ... -
On the effects of obesity treatment
(2021-05-12)Aim: In this thesis the effects of bariatric surgery in individuals with type 1 diabetes (T1D) will be assessed as well as the effects of surgery on risk for heart failure (HF) and atrial fibrillation (AF) in individuals ... -
Managing irritable bowel syndrome - Dietary approaches and food intolerance
(2021-05-11)Irritable bowel syndrome (IBS) is a complex disorder where diet plays a pivotal role in symptom generation for many patients. The aim of this thesis was to explore how diet and self-perceived food intolerance relate to ... -
Blood pressure-dependent changes in plasma volume, glycocalyx and platelet function during anaesthesia -Clinical and experimental studies
(2021-05-11)Background: Worldwide, more than 300 million surgeries are performed each year. General anaesthesia provides the surgical patient with a state of controlled loss of sensation and awareness. It is common that general ... -
Translational and clinical aspects of pancreatic cancer
(2021-05-10)Pancreatic cancer is a disease with dismal prognosis due to late detection and ineffective treatments. The majority of the patients already have disseminated disease at the time of diagnosis. The only potential curative ... -
Implant-supported restorative therapy in a Swedish population. Complications and cost evaluations
(2021-05-07)Replacing missing teeth through implant-supported restorative therapy is a common treatment procedure. While high survival rates have been reported, complications affecting the implant and/or the implant- supported ...