Doctoral Theses from Sahlgrenska Academy
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Insights from combining Action Research and System Dynamics when facilitating change and improvement processes in healthcare
(2022-09-30)BACKGROUND Healthcare is a complex system with multi-professional staff and multiple patient care pathways. Time pressure and minimal margins for error makes it challenging to implement new policies or procedures, no ... -
Acquired Epilepsy with a Focus on Stroke: Treatment and Prognosis
(2022-02-23)The relationship between epilepsy and stroke is complicated. While stroke is a major cause of epilepsy after middle age, there is also evidence that the risk of stroke is increased in persons with epilepsy. The overall aim ... -
lmprovement in perioperative care of the day case patient; logistics and quality of care.
(2022-02-23)Background: The “Day surgery concept” is increasing and nowadays numerous of surgical procedures in patients of all ages, with different comorbidities are performed as day case surgery. Day surgery (DS) is a process; not ... -
On the role of Natural Killer cell immunogenetics for the outcome of immunotherapy in acute myeloid leukemia
(2022-02-14)Numerous studies have revealed that natural killer cells have fundamental roles as effector cells in myeloid leukemias. Thus, understanding NK cell-related biomarkers that influence clinical outcome are warranted. This ... -
Blood Vessels, Biomarkers, and Broken Barriers: lnvestigations of the Brain Vasculature in Models of Neonatal Brain lnjuries
(2022-02-10)Brain injury during the perinatal period can lead to lifelong impairment in cognitive and motor function, or an early death. Term neonatal encephalopathy and preterm germinal matrix haemorrhage are two conditions that can ... -
Prerequisites for palliative care provision in intensive care
(2022-02-08)Palliative care provision is aimed at improving patients’ quality of life when cure no longer possible through healthcare systems, including intensive care. It has been ob-served that ongoing challenges exist concerning ... -
Metabolic alterations and adipose tissue dysfunction in individuals with a family history of type 2 diabetes
(2022-02-08)ABSTRACT Aims The overall aim of this doctoral thesis was to further examine the anthropometric, metabolic and adipose tissue dysfunctions, as well as explore novel metabolites, associated with type 2 diabetes mellitus ... -
Promoting the Clinical Relevance of 3D Bioprinting
(2022-02-03)This thesis focuses on the development of methodologies enabling the reconstruction of autologous, functional, and long-term-stable cartilage-like tissue using 3D bioprinting technology and animal experiments. The stability, ... -
Human iPSC-derived neuronal networks. Development and application for compound evaluation
(2022-02-03)Research on human brain development and function in health and disease has been hampered by limited access to primary human tissue and limited translatability of animal studies. This knowledge gap is encouraging the use ... -
Unmet need for mental healthcare among men Sweden: Gendered pathways to care
(2022-02-02)Aim: Depression and anxiety disorders have a lifetime prevalence of about 10% among men in high-income countries but many do not seek and receive the care that they need. The aim of this thesis was to explore gendered ... -
Process and economic evaluation of a transition program for adolescents with congenital heart disease: the Stepstones project
(2022-01-28)Transition programs have been developed for adolescents with chronic conditions and evaluated through randomized controlled trials. However, knowledge is lacking on what barriers and facilitators to implementation exist, ... -
Genomic mutational heterogeneity in cancer. lmproved models and tools for driver gene detection
(2022-01-19)Cancer is a disease that is strongly related to evolution, as mutations that confer a benefit to individual cells face positive selection and eventually lead to tumorigenesis. As such, the search for genes that drive cancer ... -
Pelvic floor dysfunction in nulliparous women
(2022-01-18)Background: Pelvic floor dysfunction (PFD) is a public health problem affecting millions of women worldwide. In addition to personal suffering, it also creates an economic burden for health care systems and society. Parity ... -
On HIV in the elderly and vitamin B metabolism in HIV infection
(2022-01-17)The evolution of the human deficiency virus (HIV) field is unparalleled in the history of infectious diseases. From the first cases in the beginning of the 1980s, when an HIV diagnosis was a death sentence, through the ... -
The role of the alpha 7 nicotinic acetylcholine receptor in inflammation and brain injury
(2022-01-13)The alpha 7 nicotinic acetylcholine receptors (α7nAChR) are expressed in the nervous system as well as on peripheral immune cells where it participates in the cholinergic anti-inflammatory pathway. Inflammation is a common ... -
Atrial fibrillation in aging; methodological aspects and the relation to dementia and cerebral vascular disease
(2022-01-12)Emerging evidence suggest an increased risk of dementia in individuals with atrial fibrillation (AF). However, until recently, few studies have investigated the relation between AF and dementia taking both prevalent and ... -
Bioabsorbable Screws for Pelvic Osteotomies in Children
(2022-01-07)Multiple conditions, with developmental dysplasia of the hip being a prime example, affect the congruity of the pediatric hip joint. A Salter osteotomy (SO) or a triple pelvic osteotomy (TPO) can be used to address suboptimal ... -
On the biological behavior of barrier membranes: implications for Guided Bone Regeneration. Clinical and Experimental studies
(2021-12-21)There is a continuous development of bone augmentation solutions to meet the rising demand for effective dental implant rehabilitations. One of the most used techniques is Guided Bone Regeneration (GBR). Although successful ... -
Predictors of bone fragility in older women. Associations in older women between risk medications and measurements of physical function, bone microstructure and fracture risk
(2021-12-20)Bone fragility with fractures constitutes a growing public health concern, resulting in suffering and major health care cost. This thesis project has been carried out by means of studies based on the SUPERB cohort of ... -
T cells in colon cancer; migration and effector functions
(2021-12-16)Immune cells are recognised as one of the main players in the tumor microenvironment and targeted by many new cancer therapies. Regulatory T cells (Treg) can suppress tumor infiltrating lymphocytes which are associated ...
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