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Genetic and molecular regulation of epithelial tube morphogenesis
(2006-09-29)Networks of epithelial tubes, such as the vertebrate lung, kidney and vascular system, enable transport of gases and nutrients to all tissues in the body. These tubes are built up by a single layer of polarized epithelial ... -
Interpretation of diagnostic information given patient characteristics
(2006-10-20)The aim with this thesis was to describe, exemplify and develop theory for reference values and diagnostic tests, especially focusing on the variability between individuals. To facilitate interpretation of medical information ... -
Mass spectrometry for comparative proteomics of degenerative and regenerative processes in the brain
(2006-12-01)Biological processes involve changes at the protein level. Proteomics aims to determine protein changes from a normal state, to measure for instance recovery or disease progression. Mass spectrometry is the most important ... -
Blood Culture Negative Endocarditis
(2006-12-05)The lethal disease infective endocarditis (IE) is caused by microorganisms that attack heart valves. Early diagnosis and identification of the causative agents are important for the choice of treatment. Optimal treatment ... -
Crisis in Energy Metabolism - Mitochondrial Defects and a New Disease Entity
(2006-12-08)Impairment of energy metabolism may be associated with severe implications for affected individuals since all fundamental cell functions are energy-dependent. Disorders of energy metabolism are often genetic and associated ... -
Computational identification of non-coding RNAs
(2007-01-12)A large amount of genomic information is now becoming available. Suitable bioinformatic tools to organize and analyze this vast amount of information are therefore important. In the case of protein genes, the majority of ... -
Analysis of Binding Events and Diffusion in Living Cells
(2007-03-06)It is well known that diffusion is the main mode of transport in living cells, but the consequences of diffusion in a complex cellular environment are not generally appreciated. In this thesis, we have investigated several ... -
Oxidant-induced cell death in lymphocytes: mechanisms of induction and resistance
(2007-04-16)Reactive oxygen species (oxidants, oxygen radicals) produced by the phagocytic NADPH oxidase have pivotal roles in immunity. Patients lacking a functional NADPH oxidase suffer from chronic granulomatous disease, which is ... -
Regulation of mucosal inflammation by fibroblasts
(2007-04-20)ABSTRACT Acute inflammation in the bowel, a response of the immune system to infections or trauma, is probably a frequent but localized event, but when the barrier is repaired and the infection cleared, it is quickly ... -
Evolution of human alpha-herpesviruses
(2007-04-24)Herpesviridae is a large virus family with more than 100 members, which are highly disseminated among animals. Three sub-families have been classified; alpha-herpesviruses, beta-herpesviruses and gamma-herpesviruses. Eight ... -
Antibiotic Resistance and Fitness of Escherichia coli in the Infantile Commensal Microbiota
(2007-05-14)Microbial resistance to antibiotics is a growing problem worldwide. Resistance develops not only in microbes which are the targets of the antibiotic treatment, but also in those belonging to the normal microbiota of the ... -
Antiretroviral treatment of HIV-1 in the central nervous system
(2007-05-24)HIV-1 invades the central nervous system (CNS) early in the infectious course. It establishes a chronic progressive infection, and triggers an intrathecal immune response. If left untreated, a majority of patients will ... -
Characterization of non-coding mRNA in Epstein-Barr virus
(2007-05-25)Epstein-Barr virus (EBV) is a human gammaherpesvirus that infects lymphoid and epithelial cells. The virus is the causative agent of infectious mononucleosis, a self-limiting lymphoproliferative disease, and it is additionally ... -
Anti-herpes simplex virus activities of sulfomannan oligosaccharide PI-88 and disulfated cyclitols
(2007-06-20)Herpes simplex virus (HSV) initiates invasion of human cells by binding to the cell surface heparan sulfate (HS) glycosaminoglycan chains. This step is mediated by the viral envelope glycoproteins gC and/or gB. Sulfated ... -
Development of novel immunization approaches to generate immunity in the female genital tract with special reference to genital herpes
(2007-08-22)Development of mucosal vaccines for inducing immunity in the female reproductive tract would have profound implications for the prevention of sexually transmitted diseases. Despite numerous efforts, no such vaccines are ... -
Foxi1, an important gene for hearing, kidney function and male fertility
(2007-08-27)Aim: In this study we focused on the biological importance of the forkhead transcription factor Foxi1. The overall aim was to elucidate the functional role of Foxi1 in the inner ear, kidney and epididymis. When mice ... -
Genetics and functions of innate-like lymphocyte subsets
(2007-09-21)The immune system contains three different branches: innate immunity, adaptive immunity and innate-like lymphocytes that share properties both with the innate and adaptive immune cells. The innate-like lymphocytes have the ... -
Mechanisms of dendritic cell maturation induced by intracellular bacteria infection
(2007-10-02)Dendritic cells (DCs) are essential for the development of an immune response against pathogens such as Listeria monocytogenes and Salmonella typhimurium. This is mostly because of their unique capacity to stimulate naïve ... -
Granulocyte activation by danger signals and blocking of receptor responses
(2007-10-09)Granulocytes are the most abundant cells in the peripherial blood. They serve to eliminate invading microbes and parasites and release anti-microbial agents. In the event of injury, granulocytes are recruited to damaged ... -
Application of imaging TOF-SIMS in cell and tissue research
(2007-10-19)This thesis is aimed at extending the use of TOF-SIMS (time of flight secondary ion mass spectrometry) as an analytical tool in cell and tissue research. TOF-SIMS is a relatively new method that allows analysis of the ...