Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin by Title
Now showing items 1-20 of 322
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3D Printed scaffolds as cancer microenvironment medels for drug discovery
(2022-04-05)Cancer is one of the most common diseases in the modern world and major efforts are made globally to develop new diagnostics and treatments. It originates from a cell which, at some point, has begun to divide and grow ... -
A search for prognostic biomarkers in diffuse large B-cell lymphoma with proteomics and immunohistochemistry
(2021-11-18)Diffuse large B-cell lymphoma (DLBCL), the most common lymphoma in the Western world, can by gene expression profiling or immunohisto-chemistry (IHC), be divided into two subgroups according to its “cell-of-origin”. The ... -
A study of the contribution of mast cells to vaccination - Regulatory functions of Fc gamma receptors
(2013-08-23)This thesis aimed to explore the regulatory roles of mast cells in vaccination. Mast cells have been increasingly recognized as important orchestrators of immune regulation in both health and disease, in addition to their ... -
Activation and immunoregulatory function of type II natural killer T lymphocytes
(2013-05-02)Natural killer T (NKT) lymphocytes make up a potent immunomodulatory subset of innate-like lymphocytes. NKT cells are activated by self-lipids presented by the unconventional MHC class I-like molecule CD1d, resulting in ... -
Acute and chronic peritonitis in peritoneal dialysis: neurogenic inflammation and citrate treatment
(2009-10-06)The prevalent problems associated with peritoneal dialysis (PD) are ultrafiltration failure and peritonitis. During PD the patient is sustained on a state of intraperitoneal inflammation, which over time impairs structure, ... -
Acute febrile illness in preschool children in Zanzibar - Infectious aetiologies, diagnosis and treatment
(2019-09-02)Background: A majority of the three million children in Africa that do not survive their fifth birthday die from infections that often start as a seemingly uncomplicated febrile illness. Primary health care workers ... -
Acute gastroenteritis in Rwandan children under five years of age investigated by real-time PCR
(2014-02-04)Acute gastroenteritis is a major cause of illness and death among children in developing countries. Knowledge about the aetiology is important to make the right priorities regarding preventive measures, and for the ... -
Acute respiratory infections among children in the Democratic Republic of Congo - nasopharyngeal pathogens, antibiotic resistance and vaccination
(2020-09-29)ABSTRACT Acute Lower Respiratory Infections (ALRI) remain a leading cause of morbidity and mortality among children in the Democratic Republic of the Congo (DR Congo). The pneumococcal conjugate vaccine PCV13 was ... -
Aloe barbadensis Mill. as a therapeutic option for irritable bowel syndrome – properties, bioactivity and mode of action
(2022-11-08)Irritable bowel syndrome (IBS) is a chronic and prevalent functional gastrointestinal disorder, with an incompletely understood pathophysiology. Because of the disease complexity and heterogeneity, the currently available ... -
Alphaherpesvirus infections of the central nervous system – Biomarkers, diagnostics and antiviral therapy
(2021-05-25)Abstract Herpesviruses predate the evolution of humans and are globally ubiquitous. Herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2), and varicella-zoster virus (VZV) establish latency in neuronal ... -
Analysis of Binding Events and Diffusion in Living Cells
(2007-03-06)It is well known that diffusion is the main mode of transport in living cells, but the consequences of diffusion in a complex cellular environment are not generally appreciated. In this thesis, we have investigated several ... -
ANALYSIS OF NOVEL BIOMARKERS FOR UNFAVORABLE BREAST CANCER PROGNOSIS
(2012-11-26)Breast cancer is the most common malignancy in women, and a major cause of mortality and morbidity despite the advances in diagnosis and treatment. The main challenge remains to identify novel biomarkers in order to improve ... -
Anaplastic lymphoma kinase activity, a therapeutic target, suppresses neuroblastoma cell differentiation
(2020-11-27)Neuroblastoma (NB) is the most common extracranial pediatric solid malignancy caused by the failed differentiation of precursor cells of the developing sympathetic nervous system. NB accounts for about 15% of childhood ... -
An animal model of sport related concussive brain injury
(2008-10-02)A new animal model for concussion of the type seen in professional football was developed, since current animal models did not simulate these conditions. The model is characterized by a high velocity-low mass impact to the ... -
Anti-herpes simplex virus activities of sulfomannan oligosaccharide PI-88 and disulfated cyclitols
(2007-06-20)Herpes simplex virus (HSV) initiates invasion of human cells by binding to the cell surface heparan sulfate (HS) glycosaminoglycan chains. This step is mediated by the viral envelope glycoproteins gC and/or gB. Sulfated ... -
Antibiotic Resistance and Fitness of Escherichia coli in the Infantile Commensal Microbiota
(2007-05-14)Microbial resistance to antibiotics is a growing problem worldwide. Resistance develops not only in microbes which are the targets of the antibiotic treatment, but also in those belonging to the normal microbiota of the ... -
Antibiotic resistance in the environment: a contribution from metagenomic studies
(2016-05-03)Antibiotic resistance accounts for hundreds of thousands of deaths annually, and its projected increase has made the WHO recognize it as a major global health threat. In the last decade, evidence has mounted suggesting ... -
Antiretroviral treatment of HIV-1 in Sweden with focus on virological aspects
(2021-02-11)From a clinical standpoint, there are many factors to consider when optimizing the care for people living with HIV (PLWH). With help from clinical guidelines, most obstacles can be addressed. Expanded knowledge is however ... -
Antiretroviral treatment of HIV-1 in the central nervous system
(2007-05-24)HIV-1 invades the central nervous system (CNS) early in the infectious course. It establishes a chronic progressive infection, and triggers an intrathecal immune response. If left untreated, a majority of patients will ... -
Application of imaging TOF-SIMS in cell and tissue research
(2007-10-19)This thesis is aimed at extending the use of TOF-SIMS (time of flight secondary ion mass spectrometry) as an analytical tool in cell and tissue research. TOF-SIMS is a relatively new method that allows analysis of the ...