Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin: Recent submissions
Visas titlar 121-140 av 322
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Regulatory T cells and lymphocyte migration into intestinal tumors
(2016-12-13)Tumor-infiltrating lymphocytes (TIL) are crucial for anti-tumor immunity. However, regulatory T cells (Treg) often accumulate in tumor tissue and are able to reduce both lymphocyte activity and transendothelial migration ... -
Molecular insights into mitochondrial transcription and its role in DNA replication
(2016-12-07)The mitochondrion is an organelle of the eukaryotic cell responsible for the production of most of the cellular energy-carrying molecule adenosine triphosphate (ATP), through the process of oxidative phosphorylation. The ... -
In vitro toxicity testing using human pluripotent stem cell derivatives
(2016-11-23)Toxicity testing of chemicals, drug candidates, and food additives is in need of a change. The present methods, mainly consisting of animal models with their associated ethical concerns, are expensive, time-consuming, and ... -
Herpes simplex virus type 1 infection in the central nervous system - Experimental and clinical studies
(2016-11-17)Alphaherpesvirus infections in the central nervous system (CNS) are rare but severe, and many patients show remaining neurological sequelae. While antiviral treatment has reduced the mortality, morbidity has not been ... -
Unravelling the mechanisms for mucosal tolerance induction using the CTA1R7K-X-DD immunomodulating fusion protein
(2016-11-11)Unravelling the mechanisms for mucosal tolerance induction using the CTA1R7K-X-DD immunomodulating fusion protein: Effective treatment options against autoimmune diseases Tolerance is a physiological mechanism that ... -
Forkhead genes in adipocytes and podocytes
(2016-10-27)Forkhead genes are a family of transcription factors with important functions in development and metabolism. This thesis addresses tissue-specific functions of the two forkhead genes, FOXC2 and FOXF2, using transgenic mouse ... -
Whole Genome Sequencing of Enterotoxigenic Escherichia coli
(2016-05-06)Enterotoxigenic Escherichia coli (ETEC) infections are a common cause of diarrhea but little is known about the evolution and genomic composition of ETEC. The main aim of this thesis was to generate a large collection of ... -
Butyrophilin- and Butyrophilin-like genes and their role in epithelial cell-intraepithelial T lymphocyte cross-talk
(2016-05-04)More than 50% of our immune system is located in the gut. The intestinal epithelium, which forms an interface between the organism and the environment, harbors intraepithelial lymphocytes (IELs) that comprise a mixture of ... -
Antibiotic resistance in the environment: a contribution from metagenomic studies
(2016-05-03)Antibiotic resistance accounts for hundreds of thousands of deaths annually, and its projected increase has made the WHO recognize it as a major global health threat. In the last decade, evidence has mounted suggesting ... -
Cellular, Molecular and Functional Characterization of the Tumor Suppressor Candidate MYO1C
(2016-03-29)Tumor suppressor genes play a role as a growth regulator and a gatekeeper of a cell. Their inactivation is often detected in malignant tumors. Identification of novel tumor suppressor gene candidates may help to further ... -
Herpes Simplex Virus 1 DNA replication and its role in recombination and transcription
(2015-12-17)Herpes simplex virus 1 (HSV-1) is one of nine different herpesvirus infecting man. They are all capable of establishing a life-long latent state following the primary infection. HSV-1 as well as other herpesviruses may ... -
Delineating cellular heterogeneity and organization of breast cancer stem cells
(2015-12-02)Breast cancer is characterized by a high degree of heterogeneity in terms of histological, molecular and clinical features, affecting disease progression and treatment response. The cancer stem cell (CSC) model suggests, ... -
On cerebrospinal fluid biomarkers of HIV-1 infection
(2015-11-26)HIV invades the central nervous system (CNS) shortly after transmission and is present throughout the course of infection, causing immune activation and neuroinflammation. If left untreated, more than 20% of patients with ... -
The role of intestinal dendritic cells and the microbiota during oral Salmonella infection
(2015-11-26)The intestinal pathogen Salmonella causes millions of infections per year worldwide. The immune response to these bacteria involves interactions between several cell types via specific molecules and is under the influence ... -
Recombinant Mucins with Tailored Glycosylation as Bacterial Toxin Inhibitors
(2015-11-23)Multivalent carbohydrate-based ligands that can inhibit biomedically important protein–carbohydrate interactions have therapeutic potential. One of the important targets for therapeutic intervention is the binding processes ... -
Approaches to Enhance and Evaluate the Immunogenicity of an Oral ETEC Vaccine
(2015-11-05)Enterotoxigenic Escherichia coli (ETEC) is a major cause of childhood diarrhoea in the developing world and the most common cause of travellers’ diarrhoea. A new oral multivalent ETEC vaccine (MEV) containing killed ... -
Mediator and cell cycle regulation
(2015-11-04)The multiprotein Mediator complex is an evolutionarily conserved coregulator of eukaryotic transcription. Mediator functions as a bridge between gene-specific transcription factors and the RNA polymerase II transcription ... -
Human adipose tissue morphology and function : relation to insulin sensitivity and glucose tolerance with focus on pregnancy and women with previous gestational diabetes mellitus
(2015-10-23)Obesity is a global health problem and affects women of reproductive age. During pregnancy, obesity increases the risk for gestational diabetes mellitus (GDM), in turn predisposing for type 2 diabetes (T2D). Not only the ... -
Genetic diversity of the heat labile (LT) and heat stable (ST) toxins of human enterotoxigenic Escherichia coli (ETEC): New insights into polymorphism, regulation, and gene transcription
(2015-09-16)Infection with enterotoxigenic Escherichia coli (ETEC) is a leading cause of diarrhea in children in developing countries and travelers to endemic regions. ETEC is a diverse pathogen, with a wide range of virulence factors ... -
The clinical importance of non-HLA specific antibodies in kidney transplantation
(2015-06-16)The clinical significance of human leukocyte antigen (HLA) antibodies (Abs) for hyperacute, acute and chronic antibody-mediated rejection (AMR) of kidney allografts has been clearly demonstrated. AMR occurs in the absence ...