Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin: Recent submissions
Visas titlar 241-260 av 322
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Lipooligosaccharide and Cytolethal distending toxin of Haemophilus ducreyi and antibody responses
(2010-03-31)The Gram-negative bacterium Haemophilus ducreyi causes chancroid, a sexually transmitted infection characterized by persistent ulcers on genitals. The disease is prevalent in developing countries and facilitates transmission ... -
Human eosinophils and their activation by allergens via danger signal receptors
(2010-03-05)Human eosinophilic granulocytes are polymorphonuclear cells with a powerful arsenal of cytotoxic substances in their granules, which are mainly found in the gastrointestinal mucosa, and the respiratory and genitourinary ... -
Functions of glycoprotein G of herpes simplex virus type 2
(2010-02-19)Background: Herpes simplex virus type 2 (HSV-2) is a common sexually transmitted infection with more than 500 million individuals infected world-wide. A major global health problem is that HSV-2 infection facilitates the ... -
Inflammatory mediator response to Gram-positive and Gram-negative bacteria in vitro and in middle ear infections
(2010-02-12)Based on the structure of the cell wall, bacteria are divided into Gram-positive and Gram-negative. While the cell wall of Gram-positive bacteria is thick, the cell wall of Gram-negatives is very thin and surrounded by an ... -
Functional genetic studies of Psoriasin: a potential biomarker for breast cancer with a poor prognosis
(2010-02-12)Breast cancer is the most common malignancy in women. There is a high degree of heterogeneity in breast tumours and they can be divided into subtypes that have different expression pattern and clinical outcome. Ductal ... -
Humoral and cellular immune response to Helicobacter pylori in Bangladeshi children and adults that may be related to protection
(2010-01-26)Helicobacter pylori (Hp) colonizes the human gastric and duodenal mucosa and the infection may cause peptic ulcers and gastric adenocarcinoma. Half of the world’s population is infected with Hp with the highest prevalence ... -
The interactome of the Epstein-Barr virus nuclear antigen 5 suggests novel roles in RNA and protein metabolism
(2010-01-19)Epstein-Barr virus (EBV) is a human herpes virus that infects B and epithelial cells of the oropharynx. EBV is transmitted by saliva and establishes a lifelong latency in over 90% of the world's population. During latency, ... -
Functional studies of two forkhead genes
(2010-01-14)Forkhead genes are functionally diverse and several have been linked to human disease. A previous screen for forkhead genes identified the family member FOXS1. To characterize the function of this gene, we produced a mouse ... -
Lactobacilli in the normal microbiota and probiotic effects of Lactobacillus plantarum
(2010-01-11)Lactobacilli colonise most adult individuals and are also frequently used as probiotics, i.e. bacteria which possibly have health promoting effects when ingested. In this thesis, the intestinal Lactobacillus microbiota was ... -
Presence and viability of enterotoxigenic Escherichia coli (ETEC) in aquatic environments
(2009-12-07)Enterotoxigenic Escherichia coli (ETEC) is one of the major causes of diarrhoea among children in developing countries and in travelers to these regions. The bacteria are spread via contaminated water and food, and surface ... -
Invasive Staphylococcus aureus infections
(2009-11-27)Staphylococcus aureus is a leading cause of septicaemia-related death. The aims of this thesis were to describe the epidemiology of invasive Staphylococcus aureus infections (ISA), the clinical course, and serological ... -
The Epstein-Barr Virus Nuclear Antigens 1 and 5; Study of virus-host cellular protein interactions
(2009-11-22)The Epstein-Barr virus (EBV) is the causative agent or cofactor in the aetiology of several human malignancies such as Burkitt’s lymphoma, Hodgkin’s disease, nasopharyngeal carcinoma (NPC) and lymphoproliferative disorder ... -
Trafficking of Human Dendritic Cells and B cells in Helicobacter pylori-induced Gastritis
(2009-11-13)Infection with the bacterium Helicobacter pylori is widespread throughout the world, and is associated with development of gastric and duodenal ulcer disease as well as gastric adenocarcinoma and mucosa associated lymphoid ... -
Dual roles for hepatic lectin receptors in the clearance of chilled platelets
(2009-10-29)Platelets for transfusion are stored at room temperature because refrigerated platelets are cleared rapidly from circulation. Room temperature storage causes major inconveniences for blood banks and medical risks for ... -
Acute and chronic peritonitis in peritoneal dialysis: neurogenic inflammation and citrate treatment
(2009-10-06)The prevalent problems associated with peritoneal dialysis (PD) are ultrafiltration failure and peritonitis. During PD the patient is sustained on a state of intraperitoneal inflammation, which over time impairs structure, ... -
Regulatory CD4+FOXP3+ T cells in Helicobacter pylori-induced disease
(2009-10-01)Helicobacter pylori colonize the gastric or duodenal mucosa of approximately half of the worlds’ population. Although most individuals are asymptomatic, H. pylori infection cause peptic ulcers or gastric cancer in 10-15 % ... -
The Neuroblastoma Genome and Epigenome - Patient Stratification and Identification of Candidate Genes
(2009-09-30)Neuroblastoma (NB) is a tumor of the sympathetic nervous system, and the most common extracranial tumor of childhood. The prognosis for high-stage NBs is still poor, with survival rates of about 35%. Side-effects of treatment ... -
Intestinal IgA synthesis: Localization and requirements for IgA class switch recombination
(2009-09-03)Production of IgA at mucosal surfaces is one of the most striking features of the mucosal immune system. Despite that IgA was first discovered in the 1950’s and secretory IgA described in gut secretions and breast milk ... -
Commensal microbes, immune reactivity and childhood inflammatory bowel disease
(2009-06-29)Inflammatory bowel disease (IBD) is characterized by chronic and relapsing intestinal inflammation of unknown etiology, but immune activation by the commensal microbiota probably plays a major role. The two major categories ... -
Studies on bacterial transmission pathways in a high endemic area, with a focus on Helicobacter pylori
(2009-06-29)Even though half of the world’s population is infected with Helicobacter pylori, which causes gastritis, peptic ulcer and gastric cancer, the transmission routes of these bacteria remain unknown despite extensive epidemiological ...