Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin: Recent submissions
Visas titlar 261-280 av 322
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Vaccination against cholera and ETEC diarrhea and interventions to improve vaccine immune responses.
(2009-06-10)Vaccination against cholera and ETEC diarrhea and interventions to improve vaccine immune responses Abstract Vibrio cholerae O1 and enterotoxigenic Escherichia coli (ETEC) together account for the majority of bacterial ... -
Cerebral complications in infective endocarditis
(2009-05-27)Infective endocarditis (IE) is a life-threatening disease. Cerebral embolization complicates the course in 10-40% of IE episodes. Aims of study were to investigate the frequency of cerebrovascular complications (CVC) in ... -
The MUC2 mucin -A network in the intestinal protective mucus
(2009-05-26)The intestine is covered by mucus that is the first line of defence of the epithelium. The main structural component of the intestinal mucus is the MUC2 mucin. This is a large glycoprotein with two long and heavily ... -
Regulation of innate and adaptive immune responses by Gram-positive and Gram-negative bacteria
(2009-05-20)Bacteria are classified as Gram-positive or Gram-negative, depending on their cell wall structure. The role of the bacterial cell wall in immune regulation is the focus of the current work. Most Gram-positive bacteria ... -
Norovirus, causative agent of winter vomiting disease, exploits several histo-blood group glycans for adhesion
(2009-05-20)Norovirus is recognized as the major cause of outbreaks of gastroenteritis world-wide, yet no vaccines or drugs are available for prevention or treatment of the virus infection. Challenge studies and binding studies using ... -
The female genital tract microbiota: composition, relation to innate immune factors, and effects of contraceptives
(2009-05-13)Abnormal vaginal microbiota, as in bacterial vaginosis (BV), is associated with increased risk of obstetrical and gynaecologic complications and acquisition of sexually transmitted diseases. However, very little is known ... -
Cartilage Tissue Engineering; the search for chondrogenic progenitor cells and associated signalling pathways
(2009-05-12)The socioeconomic cost of articular cartilage related diseases in the Western world is very high. The suffering of the individual patient is even more problematic. Different methods are used today to treat this large, ... -
A mouse model for direct evaluation of cholera vaccines
(2009-04-23)Cholera continues to be an important cause of morbidity and mortality in large parts of the developing world and is a significant negative factor for economic development. Vibrio cholerae bacteria of the O1 or O139 serogroup ... -
Studies of Carbohydrate-Binding Proteins from Enterotoxigenic Escherichia coli
(2009-04-06)Knowledge about the carbohydrate binding specificity of pathogens can give an increased understanding of their virulence strategies, and is also of importance for the development of anti-adhesive therapies and vaccines. ... -
Regulation of gene expression in the vascular wall
(2009-03-31)Blood vessel growth and function are closely related to a number of pathological conditions, including tumor angiogenesis, wound healing and atherosclerosis. Smooth muscle cells (SMC) and endothelial cells (EC), the two ... -
New Roles of Filamins in Cell Signaling, Transcription and Organ Development
(2009-03-12)Filamins are large actin-binding proteins that stabilize delicate three-dimensional actin networks and link them to cellular membranes. They integrate cell architectural and signaling functions and are essential for cell ... -
Genetic linkage and association studies in celiac disease: discoveries from whole genome analysis
(2009-03-06)Celiac Disease (CD) or Gluten Sensitive Enteropathy (GSE) is a life-long disorder. It is characterized by inflammation in the small intestine of genetically predisposed individuals caused by inappropriate immune response ... -
Molecular regulation of epithelial tube size
(2009-02-27)In nature, epithelial tubes are vital structures in organ design and are required for transport of gases and liquids in organs, such as the vascular system, the vertebrate lung and the kidneys. The tubular epithelium is ... -
Epidemiological and immunological studies of environmental mycobacteria - with focus on Mycobacterium abscessus
(2009-02-27)Mycobacterium avium, M. abscessus and M. gordonae are three mycobacterial species that are ubiquitous in the environment. M. gordonae is non-pathogenic, while M. avium and M. abscessus can cause skin abscesses and airway ... -
FET proteins in cancer and development
(2009-02-13)Chromosomal translocations leading to rearrangements of FET family genes (FUS, EWSR1 and TAF15) are found in numerous human cancers. These genetic alterations result in the formation of fusion oncogenes that express potent ... -
DNA damage affecting thyroidal iodide transport: an explanation to thyroid stunning
(2008-11-24)131I is widely used clinically in the treatment of Graves´ disease and differentiated thyroid cancer. However, cellular and molecular effects of 131I irradiation in relation to absorbed dose are poorly documented. For ... -
The contribution of proteins and lipids to COPI vesicle formation and consumption
(2008-11-18)In the secretory pathway, movement of proteins between compartments occurs through small (50-100 nm) vesicles. The coat of COPI vesicles is composed the small GTPase ARF1 and the large coatomer complex. In the secretory ... -
Developmental origin and molecular regulation of vascular smooth muscle cells
(2008-11-18)Several pathologies of the vascular system have been suggested to be dependent on the smooth muscle cells (SMCs) that build up the vessel wall. Aortic SMCs have been proposed to derive from lateral plate mesoderm. It has ... -
Vaginal commensal bacteria. Interactions with cervix epithelial and monocytic cells and influence on cytokines and secretory leukocyte protease inhibitor, SLPI
(2008-11-14)Vaginal commensal bacteria Interactions with cervix epithelial and monocytic cells and influence on cytokines and secretory leukocyte protease inhibitor, SLPI Louise Strömbeck Department of Infectious Medicine, ... -
Transcriptional regulation of thyroid development possible interplay of endoderm- and mesoderm-derived morphogenetic signals
(2008-10-14)Congenital hypothyroidism (CH) affects 1 in 3000 children and is the major cause of treatable mental retardation. Most cases are due to malformations of the gland, collectively named thyroid dysgenesis. The disease results ...