Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin: Recent submissions
Now showing items 161-180 of 322
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Pathophysiological impact of targeting the ROS-p53 axis
(2014-10-21)The goal of this PhD thesis was to define the importance of the interplay between reactive oxygen species (ROS) and their activation of the tumor suppressor p53 in development and disease. We addressed this question using ... -
Development of novel vaccine strains of Vibrio cholerae and studies on the role of serotype in epidemic spread of cholera
(2014-09-26)Cholera, caused by bacterium Vibrio cholerae O1, is a severe diarrheal disease with an estimated 3-5 million cases and more than 140 000 deaths every year particularly affecting children under 5 years of age. It can be ... -
Microbiota of the alimentary tract of children - implications for allergy and inflammatory bowel disease
(2014-09-19)Allergy, which is the most common chronic disease in Swedish children and adolescents, is associated with a high standard of living and Western lifestyle. According to the hygiene hypothesis, allergy is due to inadequate ... -
Neural stam cells, TLX, and Neuroblastoma
(2014-09-19)Neuroblastoma (NB) is one of the most commonly diagnosed extracranial tumors in children below five years of age. Moreover, NB accounts for almost 12-15% of all childhood cancer related fatalities. To date, the origin of ... -
Molecular factors influencing epithelial-mesenchymal transition in breast cancer
(2014-08-22)Epithelial-mesenchymal transition (EMT) is a developmental process defined by loss of epithelial characteristics and acquisition of mesenchymal phenotype. EMT or similar processes are also implicated in carcinoma cell ... -
Studies on interactions of norovirus capsid protein with fucosylated glycans and galactosylceramide as soluble and membrane bound ligands
(2014-05-19)Noroviruses (NVs) are among the most common viral pathogens which target the gastrointestinal (GI) tract and cause severe diarrhea, vomiting and episodes of abdominal cramps with fever. Millions of people around the world ... -
Mediator and its role in non-coding RNA and chromatin regualtion
(2014-05-15)Mediator is a multiprotein complex required for the regulation of RNA Polymerase II (Pol II) transcription. Mediator transmits regulatory signals from activators and repressors to the Pol II machinery at the promoter, but ... -
Lyme Neuroborreliosis - Diagnosis and Treatment
(2014-05-05)Lyme neuroborreliosis, the infection of the nervous system by the tick-borne bacterium Borrelia burgdorferi, is a common infection in the temperate parts of the Northern hemisphere. Manifestations of the disease include ... -
On the role of signaling pathways in the pathogenesis of osteoarthritis
(2014-04-15)The problem with degenerating cartilage tissues is one of the major causes for disability worldwide. The aetiology of the cartilage degenerating disease osteoarthritis is elusive and considered to be multifactorial. The ... -
Hepatitis B virus replication and integration
(2014-04-11)Chronic infection with hepatitis B virus (HBV) affects 240 million people worldwide and may cause liver disease including hepatocellular carcinoma (HCC). Initially patients have high levels of HBV DNA in their blood, no ... -
Fluoroquinolone resistance in the environment and the human gut – Analysis of bacterial DNA sequences to explore the underlying genetic mechanisms
(2014-04-04)Fluoroquinolones (FQs) are synthetic, broad-spectrum antibiotics that target type II topoisomerases. High-level resistance is often caused by mutations in the target genes of FQs, especially in gyrA and parC. In contrast, ... -
Initiation of Mammalian Mitochondrial DNA Replication
(2014-04-04)Mitochondria produce most of the adenosine triphosphate required in a eukaryotic cell and they contain their own genome. The mitochondrial DNA (mtDNA) is a double stranded circular molecule that codes for proteins required ... -
Mucus and mucins during gastrointestinal infections
(2014-03-24)The gastrointestinal tract is protected by a continuously secreted mucus layer formed by mucin glycoproteins. The mucus layer and mucins change dynamically during infection. The main focus of this thesis was to investigate ... -
Liposarcomas - proliferation, senescence and the role of DDIT3
(2014-02-28)Lipomatous tumors comprise benign and malignant forms called lipomas and liposarcomas. Myxoid/round cell liposarcoma (MLS/RCLS) is the second most common liposarcoma and is characterized by the fusion oncogenes FUS-DDIT3 ... -
Helicobacter spp. interactions with mucins: adhesion and mucin regulation of pathogen proliferation and gene expression
(2014-02-10)Helicobacter pylori colonizes the gastric mucosa of approximately half of the world’s population and is a risk factor for gastritis, peptic ulcers and gastric cancer. H. pylori is surrounded by, and adheres to, the heavily ... -
Acute gastroenteritis in Rwandan children under five years of age investigated by real-time PCR
(2014-02-04)Acute gastroenteritis is a major cause of illness and death among children in developing countries. Knowledge about the aetiology is important to make the right priorities regarding preventive measures, and for the ... -
Identification and characterization of progenitor populations in the human adult heart
(2014-01-17)Traditionally, the heart has been regarded as a non-regenerative organ. During the last 10 years, this notion has been challenged. By 14C measurements, it was calculated that at the age of 50, about 45% of all cardiomyocytes ... -
Mucin-like proteins in Drosophila development
(2014-01-17)Mucins are large and highly glycosylated proteins and major component of the mucus that coats the lining of epithelial organs. Mucins are characterized by the presence of extended regions rich in the amino acids Proline, ... -
Two new disorders of glycogen metabolism
(2014-01-08)Glycogen is a polymer of glucose and serves as a source of rapidly available energy. Glycogen synthesis is initiated by autoglucosylation of glycogenin. Two glycogenin genes, GYG1 and GYG2, encode the two isoforms glycogenin-1 ... -
Herpesvirus-induced glycans: Selectin ligands and related structures on the surface of the infected cell
(2014-01-03)Human herpesviruses are usually acquired early in life and are widely distributed in the population. A common feature of all human herpesviruses is that they persist in the host after the primary infection. Thus, the host ...