Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin: Recent submissions
Now showing items 21-40 of 322
-
T cells in colon cancer; migration and effector functions
(2021-12-16)Immune cells are recognised as one of the main players in the tumor microenvironment and targeted by many new cancer therapies. Regulatory T cells (Treg) can suppress tumor infiltrating lymphocytes which are associated ... -
Proteostasis beyond chaperones - Auxiliary systems in the management of damaged proteins
(2021-11-25)Aging entails loss of functionality and increased risk of death, even for unicellular organisms, such as the yeast Saccharomyces cerevisiae. On a cellular level, aging is accompanied by an accumulation of harmful aging ... -
FET fusion oncoproteins in sarcoma tumorigenesis - lnteractions with the SWI/SNF chromatin remodeling complex and epigenetic effects
(2021-11-23)The FET family of fusion oncoproteins containing the N-terminal of either FUS, EWSR1 or TAF15 together with a transcription factor partner is the characteristic oncogenic driver of more than 20 types of sarcoma and leukemia, ... -
A search for prognostic biomarkers in diffuse large B-cell lymphoma with proteomics and immunohistochemistry
(2021-11-18)Diffuse large B-cell lymphoma (DLBCL), the most common lymphoma in the Western world, can by gene expression profiling or immunohisto-chemistry (IHC), be divided into two subgroups according to its “cell-of-origin”. The ... -
Investigating ALK inhibitors alone or in combination as therapeutic options for ALK-positive neuroblastoma
(2021-11-16)Neuroblastoma (NBL) is the third most common pediatric cancer after leukemia and cranial tumours and accounts for around 15% of death in pediatric malignancy. NBL develops due to the poorly differentiated progenitor cells ... -
The Role of FCGBP in Mucus - Structure, Processing and Function
(2021-10-26)In this thesis, a bottom-up approach was used to study the IgG Fc-binding protein (FCGBP), which next to the MUC2 mucin is the second main component of secreted mucus in small intestine and colon. FCGBP is also found in ... -
Computational studies of mutational sequence signatures in cancer genomes
(2021-10-08)Cancer typically forms when mutational processes modify key cancer driver genes, resulting in positive selection and tumor growth. As such, mutational processes are at the core of the disease. Trinucleotide mutational ... -
The impact of the progranulin-sortilin axis on breast cancer stem cell activity and patient outcome
(2021-08-18)Breast cancer is the most common cancer in women worldwide. Still today, despite current breast cancer therapies, many patients experience treatment resistance and relapse, which are believed to be due to failure in targeting ... -
Pan-cancer study of transcriptional responses to oncogenic somatic mutations
(2021-05-27)Cancer cells typically carry acquired somatic mutations in key cancer driver genes, which can be identified on the basis of recurrence in cancer cohorts. Such mutations may cause aberrant protein activity and altered gene ... -
Alphaherpesvirus infections of the central nervous system – Biomarkers, diagnostics and antiviral therapy
(2021-05-25)Abstract Herpesviruses predate the evolution of humans and are globally ubiquitous. Herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2), and varicella-zoster virus (VZV) establish latency in neuronal ... -
The role of wastewater in surveillance and emergence of antibiotic resistant bacteria
(2021-05-25)As antibiotic resistance spreads among bacterial pathogens, it reduces treatment options and increases treatment failures of infectious diseases. Strategies employed to reduce this spread or adapt to its consequences ... -
Ribonucleotides in DNA - Application in genome-wide DNA polymerase tracking and physiological role in eukaryotes
(2021-05-20)The genetic code in the eukaryotic cell is stored in the form of DNA, which is more resistant to hydrolysis than RNA. Replication fidelity and DNA repair mechanisms are in place to ensure genomic integrity to preserve the ... -
On the Origins of mobile Antibiotic Resistance Genes
(2021-05-17)Mobile antibiotic resistance genes (ARGs), transferable between bacterial cells, are major contributors to the antibiotic resistance crisis we are facing today. From which organisms pathogens acquired these genes is ... -
Multiple primary malignancies in breast cancer patients. From population study to genetics
(2021-04-16)Breast cancer (BC) is one of the most common causes of cancer-related death among women worldwide. Due to early detection of BC and more tailor-made treatments, patients live longer despite their illness. Studies have shown ... -
On chaperone co-operation in temporal and spatial protein quality control
(2021-03-29)In order for a protein to be able to function correctly it needs to adopt its proper fold. Because of this, protein quality control (PQC) is vital at every level of cellular function. The central protein in PQC networks ... -
Glycan dependent Helicobacter spp. and Streptococcus oralis binding to mucins in the gastric and oral mucosal niches
(2021-03-26)Helicobacter pylori infects the stomach of half of the world’s population, while Helicobacter suis colonizes pigs and is the most common non-H. pylori Helicobacter species that also infects human stomach. Infection with ... -
Ultrasensitive DNA sequencing using liquid biopsies enables precision medicine
(2021-03-18)Liquid biopsies are minimally invasive and allow repetitive sampling of body fluids. Analysis of cell-free tumor DNA in liquid biopsies can be used as a biomarker for cancer. However, in most clinically relevant liquid ... -
Molecular insights into primer removal during mtDNA replication
(2021-03-01)Mitochondria are vital for cell survival, and the primary producers of ATP, the energy currency used for various metabolic processes. Mitochondria are unique from other cellular compartments ... -
Antiretroviral treatment of HIV-1 in Sweden with focus on virological aspects
(2021-02-11)From a clinical standpoint, there are many factors to consider when optimizing the care for people living with HIV (PLWH). With help from clinical guidelines, most obstacles can be addressed. Expanded knowledge is however ... -
Molecular and genetic studies in high-risk neuroblastoma
(2021-02-04)Neuroblastoma is the most common and deadly cancer in the first year of life. Children with high-risk neuroblastoma have a very poor prognosis, despite heavy multimodal treatment, with less than 50% of 5 years of overall ...