Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin: Recent submissions
Now showing items 201-220 of 322
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Molecular analysis of the FET family fusion oncoprotein FUS-DDIT3
(2012-12-20)Chromosomal translocations leading to formation of tumor type specific fusion oncogenes are frequently found in human cancers. The FET family genes (FUS, EWSR1 and TAF15) occur in translocations with genes encoding various ... -
ANALYSIS OF NOVEL BIOMARKERS FOR UNFAVORABLE BREAST CANCER PROGNOSIS
(2012-11-26)Breast cancer is the most common malignancy in women, and a major cause of mortality and morbidity despite the advances in diagnosis and treatment. The main challenge remains to identify novel biomarkers in order to improve ... -
Cellular studies of neuromuscular disorders related to the sarcomeric proteins
(2012-11-21)Sarcomere is the basic unit of cardiac and skeletal muscle contraction and its proper function requires an invariant organization of this structure. Mutations in sarcomeric proteins are known to cause increasing number ... -
The Relationship between Transmembrane Mucins, Ion Channels and PDZ Adaptor Proteins in the Small Intestine
(2012-10-26)The human body is continuously exposed to challenges from the surrounding world. In analogy with the skin, mucus is a well-organized and highly regulated barrier composed of polymeric and O-glycosylated mucins that ... -
Monoclonal antibodies against human papillomavirus E7 oncoprotein for diagnosis of cervical neoplasia and cancer
(2012-10-08)Cervical cancer is the second most common cancer among women worldwide with half a million of new cases every year. Cervical cancer is caused by oncogenic human papillomaviruses (HPVs), with HPV16 and 18 being the most ... -
Measurements of the DNA double-strand break response
(2012-09-25)Radiotherapy and some chemotherapeutic drugs kill cancer cells by induction of the extremely toxic DNA double-strand breaks (DSBs). Measurements of the DSB response in patients during therapy could allow personalized ... -
Characterization and persistence of potential human pathogenic vibrios in aquatic environments.
(2012-06-18)Vibrio spp., natural inhabitants of aquatic environments, are one of the most common causes of bacterial gastroenteritis in the world, being spread to humans via the ingestion of seafood, contaminated drinking water or ... -
Mechanisms of leukemia-induced immunosuppression
(2012-05-25)This thesis aimed to define the role of reactive oxygen species (ROS), produced by the NADPH oxidase of myeloid cells, in the regulation of lymphocyte function with focus on ROS-induced dysfunction of natural killer (NK) ... -
Molecular characterization of neuroblastoma tumors - a basis for personalized medicine.
(2012-05-24)Neuroblastoma is a very heterogeneous tumor, with a clinical course ranging from spontaneous regression to aggressive tumor growth. A proper stratification of the patients into different risk groups is therefore important ... -
Mechanistic studies of the adjuvant effects of CTA1-DD and the native cholera toxin: Impact of cell targeting and tissue localization
(2012-05-15)Vaccines are the most effective means of preventing infectious diseases and improving global health. However, few vaccines have successfully been developed for protection at mucosal surfaces where most pathogens gain access. ... -
Real-time PCR studies of genotypes, mutations and replication of hepatitis B virus
(2012-02-10)Infection with hepatitis B virus (HBV) is an important cause of liver disease and affects 350 million people worldwide, causing 600,000 deaths/year. Treatment includes interferon and nucleoside analogues (NAs) such as ... -
Targeting the human glycoproteome: new enrichment protocols and mass spectrometric analyses reveal unique and novel glycosylation sites
(2012-02-10)Glycosylation is one of the most common and structurally diverse posttranslational modifications of proteins. Given that protein glycosylation is involved in various cellular processes, the characterization of site-specific N- ... -
Giant Cell Arteritis - Pathogenetic and Epidemiological Aspects
(2012-01-20)Giant cell arteritis (GCA) is a chronic inflammatory disorder of medium-size and large arteries which affects people aged 50 years or older with a female preponderance. The two different expressions of GCA are temporal ... -
Invasive Pneumococcal Infections
(2011-12-21)Streptococcus pneumoniae is a major cause of disease, ranging from uncomplicated respiratory infections to severe invasive pneumococcal disease (IPD), including bacteraemic pneumonia, septicaemia with unknown focus and ... -
Interplay between Pathogenic and Immune Regulatory Mechanisms in G-alpha-i2 deficient colitis
(2011-12-20)The two major forms of inflammatory bowel disease (IBD), Crohn's disease (CD) and ulcerative colitis (UC) are gastrointestinal disorders characterized by chronic and relapsing inflammation. Mice deficient in the inhibitory ... -
Virulence factors and clonal relatedness of enterotoxigenic Escherichia coli (ETEC) isolated from children with diarrhoea in Bolivia
(2011-11-25)Enterotoxigenic Escherichia coli (ETEC) is one of the major causes of diarrhoea in children under five years of age in developing countries and in travellers to these settings. To cause disease, ETEC must be able to colonize ... -
On the outcome of antiviral therapy for hepatitis C virus genotype 2 or 3 infection
(2011-11-09)Abstract Approximately 80% of patients infected with HCV genotypes 2 or 3 achieve a sustained virological response (SVR), following 24 weeks of therapy with ribavirin and pegylated interferon (peg-IFN), but in light of ... -
Chemical basis of ABO subgroups
(2011-10-28)Despite the ABO histo-blood group system being the most biologically significant in humans the chemical structures that define its various phenotypes still remain largely unresolved. Like all blood group systems there ... -
Studies of gene fusions and copy number alterations in salivary and adnexal neoplasms
(2011-05-27)Cancer is a genetic disease caused by the accumulation of genetic changes such as mutations and chromosomal rearrangements. An increasing number of genetic studies of both hematological and solid neoplasms have shown ... -
On the stimulatory effect of microglial cells on angiogenesis
(2011-05-26)ABSTRACT Angiogenesis, the process by which new vessels sprout from pre-existing vessels, is fundamental to development, tissue growth and repair. The main aim of this thesis was to investigate the role of microglia on ...