Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi: Recent submissions
Now showing items 41-60 of 434
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The medical perspective in prescribing: measurements and educational strategies
(2021-08-18)Background and aims: Drug treatment is a keystone in modern healthcare and for safe prescribing of drugs, an overall medical perspective has to be applied, taking patient characteristics into account. For each medication, ... -
Defense-related inhibition of sympathetic nerve activity: Insights from neuroimaging and monozygotic twins on related cortical processes and clinical potential
(2021-05-27)This thesis investigates a physiological phenomenon observed in the peripheral sympathetic nervous system in response to various stressors and tries to bring it closer to clinical research. Sudden surprising stimulation ... -
Measuring outcomes following brain tumor surgery: a registry based approach
(2021-05-27)Meningiomas and vestibular schwannomas (VS) are generally slow-growing and benign brain tumors, with low rates of tumor-related mortality. Surgery is rarely the only viable treatment option. In cases where there is no clear ... -
Candidate biomarkers for synaptic pathology: neurogranin, neuroligins and neurexins in neurodegenerative disorders
(2021-05-14)Synapses are small units through which neurons communicate in the brain. They represent the site of memory formation and cognitive abilities and are thus primarily affected by neurodegenerative diseases such as Alzheimer’s ... -
Risk factors for dementia. Lifestyle, hormones, neurochemistry, and genetics
(2021-05-12)Objective: The aim of this thesis was to expand the understanding about the effects of lifestyle factors, indicators of endogenous estrogens, and genetic factors on the risk of dementia and cerebrospinal fluid (CSF) markers ... -
Recidivism and Static-99R risk assessments in a Swedish cohort of mentally disordered sexual offenders
(2021-05-07)Mentally disordered sexual offenders (MDSOs) constitute a heterogeneous offender subgroup presenting a wide range of clinical comorbidity. The recidivism rates for such a disparate subgroup vary substantially, which ... -
Pituitary Tumor Surgery - factors influencing outcome
(2021-05-05)Background: Pituitary tumors represent 15–20% of intracranial tumors. The majority are benign adenomas, of which 30 % are hormonally inactive, the non-functioning pituitary adenomas (NFPAs). A possible neuronal damage ... -
Cerebrospinal fluid biomarkers and cognition in older adults
(2021-04-21)Alzheimer’s disease (AD) is the most common type of dementia. The cause of the disease is unknown, but a substantial amount of evidence suggest that the disease is started by an imbalance in the production and clearance ... -
Alzheimer's disease and vascular dementia in population-based studies
(2021-03-30)Dementia, a clinical syndrome with several profiles and causes, is characterised by a decline in cognitive functions, including memory, learning, executive function, attention, language, and social ability. The most common ... -
Enriched, task specific therapy in the chronic phase after stroke
(2021-03-29)Recovery and improvement of motor functions and abilities after stroke depend on the spontaneous recovery process but also on the reorganization of neural mechanisms. In animal studies, an Enriched Environment (EE) has ... -
Characterization of secretory mechanisms in lacrimal and salivary glands
(2021-03-25)Dry mouth and dry eyes are multifactorial morbidities that can lead to a severely reduced quality of life. Approximately 20% of the population suffers from ocular or oral dryness. In the pursuit of pharmacological treatments ... -
Fetal Alcohol Spectrum Disorders in Children and Young Adults with an emphasis on ophthalmology
(2021-02-26)Introduction: Fetal alcohol spectrum disorders (FASD) are a group of disorders caused by prenatal alcohol exposure (PAE). The most severe and most studied FASD condition is fetal alcohol syndrome. Other conditions include ... -
Registry-based studies of return to work after stroke - part of the work after stroke study (WASS)
(2021-02-15)Objectives. Stroke is one of the most common diseases and a main cause of disability both globally and in Sweden. Even though the risk increases with older age, stroke in the younger population is increasing and a substantial ... -
Fluid biomarkers of extracellular matrix remodelling across neurological diseases
(2021-02-12)Neurological diseases constitute a major health and socioeconomic issue. Despite an enormous amount of research going on globally, the prevalence and mortality of neurological disorders are still rising. This has placed a ... -
Hearing in early old age: current perspectives
(2021-02-08)Age related hearing loss is a public health concern that restricts the possibilities of older persons to lead a healthy, social and active life. The present thesis aims to provide contemporary perspectives on age related ... -
Characterization of immune cell profiles in meninges and brain parenchyma following injury in the developing mouse brain
(2021-02-04)Preterm newborns are particularly susceptible to complications such as hypoxia-ischemia (HI), which can result in brain injury and subsequent cognitive and/or motor function disabilities, including cerebral palsy. Immune ... -
Neurobehavioral correlates of disinhibitory psychopathology
(2020-11-20)Disinhibitory psychopathology refers to maladaptive behavioral expressions stemming from problems with impulse control. Despite a robust association with antisocial and criminal behavior, knowledge about the neurobehavioral ... -
Restrictive eating disorders: aetiological, epidemiological and neurodevelopmental aspects
(2020-11-20)Restrictive Eating Disorders (EDs), including Avoidant/Restrictive Food Intake Disorder (ARFID) and Anorexia Nervosa (AN), are characterised by severely restricted food intake, commonly leading to substantial weight loss ... -
Autism and ADHD in children with cerebral palsy
(2020-11-13)BACKGROUND: Autism spectrum disorder (autism) and attention-deficit/hyperactivity disorder (ADHD) are likely underdiagnosed in children with cerebral palsy (CP). Early identification of impairments is important for adequate ... -
Treatments and outcomes in bipolar disorder
(2020-11-02)Bipolar disorder is defined by recurring mood episodes and patients have a markedly increased risk of suicide. Pharmacological and psychological treatments for bipolar disorder have proven efficacy in clinical trials ...