Sahlgrenska Academy / Sahlgrenska akademin: Recent submissions
Now showing items 401-420 of 2677
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Decellularization as a method to generate a new generation of vascular grafts
(2020-04-29)Decellularization of blood vessels is a technique to remove cells from the extracellular matrix (ECM), which can be used as a vascular graft for peripheral or coronary blood vessel bypass surgery. This thesis focuses on ... -
Release and Clearance Mechanisms of Cardiac Troponin
(2020-04-28)Myocardial infarction (MI) is often suspected when a patient presents with chest pain. MI is defined as cardiac necrosis due to ischemia, most often mediated through impaired coronary perfusion. Cardiac necrosis results ... -
Virtual reality based kinematics for assessment of post-stroke upper limb function
(2020-04-28)The main scope of this thesis was to develop a method for assessing the upper limb sensorimotor function following stroke using virtual reality-based technique. The studies reported in this thesis included 67 individuals ... -
Depression among Swedish 70-year-olds - Sex differences from a gender perspective
(2020-04-28)Depression is one of the leading causes of global burden of disease. Due to increased life expectancy, late-life depression is an escalating public health issue. The prevalence is reported to be almost twice as high among ... -
Congenital Heart Disease, Type 1 and Type 2 Diabetes Mellitus
(2020-04-28)Worldwide, 1% of all live born children are born with a congenital heart disease (CHD) and currently >95% reach adulthood due to better diagnostics and medical care. At the same time, Diabetes Mellitus (DM), type 1 (T1DM) ... -
Investigating the role of Class-1 Phosphoinositide 3 Kinases (PI3Ks) in insulin signaling and obesity
(2020-04-28)Obesity and obesity related diseases such as type 2 diabetes, cardiovascular disorders, and different types of cancer are leading causes of mortality and morbidity in modern society. However, the mechanism that links obesity ... -
Underlag för information om covid-19 vid trångboddhet och flergenerationsboende
(Samhällsmedicin och folkhälsa, Göteborgs universitet, 2020-04-23)Trångboddhet är en välkänd riskfaktor för luftvägsinfektioner. Att bo flera generationer tillsammans under trånga förhållanden gör det särskilt svårt att skydda de äldre som löper ökad risk för svår covid-19 infektion. De ... -
Impact of Genetic Variants in Inosine Triphosphate Pyrophosphatase and Interferon-λ4 on Natural History, Treatment Response and Ribavirin Pharmacology in Hepatitis C Virus Infection
(2020-04-23)Hepatitis C virus (HCV) impacts on global health with around 70 million chronically infected worldwide. The infection increases the risk of cirrhosis and primary liver cancer. The treatment until 2013 has been based on ... -
On Aging, Behavior and the Role of PA28αβ in Protein Homeostasis
(2020-04-23)As life expectancy increases, understanding challenges related to the processes of aging are more relevant than ever. Common age-related diseases progress as consequences of accumulative protein damage and protein aggregates. ... -
Cardiovascular disease in patients with congenital heart disease
(2020-04-23)Background: Today, about 95% of children with congenital heart disease (CHD) survive into adulthood and the survival in patients with CHD has increased considerably during the last decades. With increasing age, patients ... -
Patient safety during intrahospital transports in intensive care. Hazards, experiences and future measurements
(2020-04-16)Patient safety is an attribute of the healthcare system that minimizes the incidence of adverse events (AEs), and that entails identifying the causes of harm and preventive strategies. Intrahospital transport (IHT) of ... -
Covid-19 i trångbodda förorter och på äldreboende - Samverkande strukturella faktorer?
(Samhällsmedicin och folkhälsa, Göteborgs universitet, 2020-04-16)Syftet med denna studie är att kartlägga olika strukturella förhållanden i Stockholm, Göteborg och Malmö som hypotetiskt skulle kunna bidra till den ökade Covid-19 frekvensen i vissa förorter. Kartorna visar att trångboddhet ... -
Safety and quality aspects of IVF - neonatal and maternal outcomes following advanced techniques
(2020-04-15)Background: Singletons born following assisted reproductive technology (ART) have adverse neonatal outcome compared to singletons born following spontaneous conception (SC). Moreover, the women undergoing ART are at an ... -
Novel biomarkers associated with histotype and clinical outcome in early-stage ovarian carcinoma
(2020-04-15)Ovarian cancer is a collective name for multiple malignancies deriving from or involving the ovary, mainly comprising five histotypes of epithelial origin (clear-cell (CCC), endometrioid (EC), high-grade serous (HGSC), ... -
Aspects of heart failure development and prevention in women
(2020-04-15)Heart failure (HF) is a severe progressive condition. Women more often are older and suffer from heart failure with preserved ejection fraction (HFpEF), contrasting to men who more often are younger and suffer from heart ... -
Physical fitness and exercise in adults with congenital heart disease
(2020-04-14)Background: The population of patients with adult congenital heart disease (ACHD) is growing, and the estimated life expectancy has increased. Therefore, factors related to lifestyle, such as physical activity (PA), exercise, ... -
Fast-track programs in total hip and knee replacement at Swedish hospitals - influences on safety, outcome and patients' experiences
(2020-04-14)ABSTRACT Background Fast-track is a care concept that aims to enhance recovery after surgery, resulting in shortened perioperative hospital stay. By using evidence-based methods in preparation and perioperative care ... -
Hyperbaric oxygen treatment for pelvic radiation-induced injuries. From a multicenter randomized controlled trial to an experimental cell model
(2020-04-03)Introduction Cancer is affecting a growing number of persons. Still, the treatment and survival of cancer is improving. Radiation therapy is used in the treatment of cancer. Late radiation-induced injuries afflict 5–15% ... -
Understanding normal-tissue late effects in the intestines after pelvic radiotherapy
(2020-04-02)Radiotherapy cures patients from deadly cancer, alone or in combination with other treatments. The photons must pass through normal tissue to converge on the tumor, and it is unavoidable that radiotherapy causes acute as ... -
Measurement of outcome in lumbar spine surgery
(2020-04-02)BACKGROUND. The purpose of elective lumbar spine surgery is mainly to reduce pain and to improve physical function and quality of life. The quality and results of the interventions are monitored in the Swedish spine register, ...