Institute of Medicine / Institutionen för medicin: Recent submissions
Now showing items 241-260 of 1073
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Ostructive lung disease - occupational exposures, smoking and airway inflammation
(2017-02-06)Abstract Obstructive lung disease is a group of respiratory diseases characterized by airways obstruction. Among them the more frequent are asthma and chronic obstructive pulmonary disease (COPD). Obstructive lung ... -
Adaptive immune maturation in relation to allergic disease and vaccine responses in children
(2017-01-30)Adaptive immune maturation in children is likely the result of a complex interplay between both intrinsic and environmental factors, but surprisingly little is known about how early life immune maturation is related to ... -
Arbetsmiljö och prostatacancer
(Arbets- och miljömedicin, Göteborgs universitet, 2017-01-21)Vid genomgång av 147 reviewartiklar rörande yrkesexponering för prostata cancer identifierades 28 potentiella yrkesrelaterade riskfaktorer. Efter att ha uteslutit exponeringar på grund av att studiekvaliteten bedömts varit ... -
Functional Modulation of the Pattern Recognition Formyl Peptide Receptors in Neutrophils - Lipopeptides - allosteric modulators of G-protein coupled receptors
(2017-01-20)G-protein-coupled receptors (GPCRs), which are the largest class of cell-surface receptors, are involved in a range of physiologic processes and pathologies, making this a highly interesting group of proteins as targets ... -
Clinical hypertension - from early prediction to prevalence, treatment adherence and outcome of resistant hypertension
(2017-01-19)Aims The four studies in this thesis highlight both undetected hypertension and hypertension in patients receiving extensive blood pressure treatment. The aim of the fi rst study was to investigate whether, and by which ... -
The pro-atherogenic role of Intimal hyperplasia
(2016-12-22)Atherosclerosis is a leading cause of mortality worldwide, and results from accumulation of plasma lipoproteins, mainly low-density lipopro-teins (LDL), in the sub-endothelial layer of the arterial wall. In this the-sis, ... -
COPD: Incidence, prognosis and co-morbidity with special focus on heart disease
(2016-12-20)The aim of the thesis was to contribute to the knowledge on chronic obstructive pulmonary disease (COPD) with respect to incidence, risk factors, prognosis and comorbidities. With the epidemiological approach, samples from ... -
Effects of growth hormone in the hippocampus and cortex of adult rodents
(2016-12-07)Background and Aims: Growth hormone (GH) affects proliferation, regeneration and specific plasticity in the adult brain. We aimed to investigate new mechanisms of local and circulating GH in the brain, and to explore the ... -
Carbonic anhydrase activity in sleep apnea - a potential therapeutic mechanism for intervention
(2016-11-30)There is no pharmacological treatment for obstructive sleep apnea (OSA) in clinical practice. The overall aim of this thesis was to investigate the effect of carbonic anhydrase (CA) enzyme activity on sleep apnea severity ... -
Axial spondyloarthritis - with special emphasis on prevalence, perceived health and predictors
(2016-11-18)The objectives of this thesis were to assess the validity of the diagnostic codes for ankylosing spondylitis and undifferentiated spondyloarthritis in the national patient register (study I), and to estimate the prevalence ... -
Risk factors of type 2 diabetes and excess risk of stroke in patients with diabetes
(2016-11-17)The incidence of type 2 diabetes is increasing worldwide, mainly because of increasing life expectancy and changes in lifestyle. However, several other factors may also increase the risk of type 2 diabetes and their ... -
Non-invasive assessement of coronary flow velocity: Clinical and experimental studies
(2016-11-17)BACKGROUND AND OBJECTIVES Coronary flow velocity (CFV) and coronary flow velocity reserve (CFVR) evaluated by transthoracic ultrasound is a promising method to assess ischemic heart disease. CFVR is the ratio between ... -
Exhaled particles for monitoring of airway inflammation
(2016-11-17)Non-invasive collection methods suitable for studying the composition of the respiratory tract lining fluid (RTLF) in small airways are currently not readily available. The overall aim of this thesis was to contribute to ... -
Estrogens and interleukin-17 in arthritis and associated osteoporosis
(2016-11-15)Rheumatoid arthritis (RA), a disease characterized by persistent joint inflammation and joint destruction, is frequently associated with generalized osteoporosis. A female preponderance (3:1) is present in RA, and ... -
Dyspnea, with a focus on cardiovascular diseases: A primary health care perspective
(2016-11-11)Aim: The overall objective of our thesis is to describe, identify, and quantify the essential aspects of dyspnea both as a stand-alone symptom and as a symptom in patients with a special focus on cardiovascular diseases ... -
A gender perspective on irritable bowel syndrome: symptoms, experiences and the development of a person-centred support intervention
(2016-11-10)Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder which affects approximately ten percent of the world’s population and which is more prevalent among women than men. The hallmark symptoms of ... -
Gastrointestinal Symtoms and Fatigue in Patients with Quiescent Ulcerative Colitis
(2016-11-10)Gastrointestinal symptoms compatible with Irritable Bowel Syndrome (IBS) and fatigue are common in patients with quiescent ulcerative colitis (UC). The causes of these symptoms remain to be clarified. The overall aim of ... -
From efficacy to effectiveness: Two randomized controlled trials of lifestyle intervention postpartum
(2016-11-07)The overall aim of this thesis was to evaluate if, and how, weight loss can be achieved in women with overweight and obesity after pregnancy by combining results from two randomized controlled trials; LEVA and LEVA in Real ... -
The Role of Insulin and Insulin-like Ischemic Stroke and Cognitive Impairment
(2016-11-02)Background and aims: Insulin, insulin-like growth factor-I (IGF-I), and the six high-affinity IGF-binding proteins (IGFBPs) play an important role in growth, metabolism and regeneration throughout the entire life span. In ... -
Heart failure in the elderly: clinical phenotype, prognosis and influencing factors
(2016-11-01)Background: Heart failure has high morbidity and mortality and the incidence increases with age. Most randomized studies in heart failure were conducted in younger heart failure patients, despite the fact that the majority ...