Institute of Clinical Sciences / Institutionen för kliniska vetenskaper: Recent submissions
Now showing items 481-500 of 582
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Factor V Leiden mutation and pregnancy. Haemostasis during pregnancy in non-carriers and carriers of factor V Leiden mutation, with special emphasis on placenta-mediated and venous thromboembolic complications and on blood coagulation and fibrinolysis markers for prediction of complications
(2009-10-12)Factor V Leiden (FVL) mutation elevates the risk of venous thromboembolism (VTE) in general. During pregnancy, the haemostatic balance is changed in the direction of hypercoagulability, resulting in an increased incidence ... -
Central nervous modulation of pain - a clinical and experimental study
(2009-10-12)This series of studies addresses several conceptual issues in modern pain therapy related to the contemporary understanding of mechanisms and modulators involved in the pain sensation. Novel invasive therapy for severe ... -
Prostate Cancer and Its Influence on Men´s Daily Lives
(2009-09-30)Prostate cancer has been a disease of older men but age at diagnosis is falling in Sweden. Fatigue has been regarded as a common symptom of cancer and may compromise quality of life in prostate cancer patients. The overall ... -
Studies on nutrition, body composition and bone mineralization in healthy 8-yr-olds in an urban Swedish community
(2009-09-30)Background: The incidence of welfare diseases including overweight in childhood is increasing worldwide. The results from a study of healthy pre-school children showed that in a population with well educated parents 17% ... -
CT Colonography: implementation and technical developments
(2009-09-29)Background: Computed tomographic colonography (CTC) is a minimally invasive imaging method for the detection of colorectal neoplasms. Uncertainty about its diagnostic performance, optimal visualization method, long learning ... -
Clinical, biochemical and morphological aspects of cervical ripening in the first trimester
(2009-09-18)Background: The uterine cervix has the ability to be transformed from being a rigid organ in non-pregnant women to become a loose structure that dilates and allows passage of the foetus at parturition. This process, cervical ... -
Longitudinal study of infants with high-grade vesicoureteral reflux
(2009-09-09)Background: Infants with congenital high-grade vesicoureteral reflux (VUR) have been regarded as a special group amongst children with reflux, with their own characteristics concerning renal damage, gender, resolution rate ... -
Migration of Natural Killer Cells. Matrix interaction, locomotion and regulation of matrix metalloproteinases (MMPs) by IL-2 and chemokines
(2009-08-28)Activated natural killer (NK) cells are effective anti-tumour cells. In order to reach target cells in a tumour mass they need to migrate in the extravascular space. The process of tumour localisation begins when the NK ... -
Pulmonary ventilation and perfusion assessed by electrical impedance tomography - Experimental studies in pigs
(2009-08-28)Pulmonary ventilation and perfusion and ventilation/perfusion (V/Q) matching determine gas exchange in every lung unit in the healthy state and in the pathologically altered lung. Mismatch of V and Q lead to hypoxaemia and ... -
On Possibly Bioactive CP Titanium Implant Surfaces
(2009-06-29)Background Osseointegrated titanium implants are routinely used in clinical dentistry. Although the overall clinical results are good, there are situations when an improved implant healing is desirable, for instance in ... -
Olfactory function after total laryngectomy in Swedish patients after rehabilitation with the Nasal Airflow-Inducing Maneuver
(2009-06-17)After a total laryngectomy the upper and lower airways are disconnected resulting in a wide range of adverse effects, e.g. deterioration of nasal functions in breathing, loss or decrease of normal sense of smell and taste, ... -
Shoulder Kinematics and Impingement. Dynamic Radiostereometric analysis of the shoulder
(2009-06-10)Abstract This study aimed to evaluate the three-dimensional kinematics of the shoulder joint in patients with shoulder impingement and controls with focus on three well known diagnostic tests; painful arc test (active ... -
Influence of postoperative treatment, surface treatment and stem design on the outcome of primary total hip arthroplasty
(2009-05-20)Aims: The aim of this study was to investigate the influence of postoperative treatment, surface treatment and stem design on the outcome of primary Total Hip Arthroplasty. The main intention was to study anteverted femoral ... -
Genetic Analyses of Tumor Progression in Colorectal Cancer
(2009-05-20)Colorectal tumors are responsible for more than 600 000 deaths per year worldwide and thereby constitute the second most common cause of cancer related mortality. Early detection is related to improved prognosis and ... -
Clinical and genetical aspects of Celiac Disease
(2008)Celiac disease (CD), or gluten-sensitive enteropathy, is one of the most common chronic diseases in childhood but is diagnosed in all ages. CD is a genetically driven immunological intolerance to dietary gluten. Th e ... -
Novel biomarkers prediciting long-term survival in breast cancer.
(2009-05-15)Breast cancer is the most common malignancy among women, affecting over a million women worldwide every year. During the last decades, there has been a dramatic increase in the survival rates due to earlier detection and ... -
Biochemical studies of carbohydrate blood group antigens - Carbohydrate phenotype in relation to cellular glycosyltranferases.
(2009-05-15)The possibility to alter the cell surface carbohydrate expression by insertion or deletion of glycosyltransferase genes is a powerful technique to study the biological function of selected carbohydrate antigens. However, ... -
Invasive and Metastatic Properties of Advanced Prostate Cancer
(2009-05-15)Prostate cancer is initially androgen-dependent (AD) and therefore androgen deprivation therapy (ADT) is generally used to treat advanced prostate cancer. However, the long-term treatment effects are insufficient and over ... -
Long-term results after partial knee arthroplasty with the Oxford Knee
(2009-05-14)Introduction Osteoarthritis of the knee is one of the most common reasons for disability, especially in elderly people. Surgical treatment is still controversial. Unicompartmental knee arthroplasty, i.e. partial knee ... -
Characterization of genetic alterations in ovarian cancer associated with chemotherapy response
(2009-05-13)Ovarian cancer is the most lethal of all gynecological malignancies, and exhibit an overall fiveyear survival rate of only 48% in Sweden. The high mortality in ovarian cancer is largely due to late diagnosis and chemotherapy ...