Institute of Clinical Sciences / Institutionen för kliniska vetenskaper: Recent submissions
Now showing items 121-140 of 582
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Understanding normal-tissue late effects in the intestines after pelvic radiotherapy
(2020-04-02)Radiotherapy cures patients from deadly cancer, alone or in combination with other treatments. The photons must pass through normal tissue to converge on the tumor, and it is unavoidable that radiotherapy causes acute as ... -
Measurement of outcome in lumbar spine surgery
(2020-04-02)BACKGROUND. The purpose of elective lumbar spine surgery is mainly to reduce pain and to improve physical function and quality of life. The quality and results of the interventions are monitored in the Swedish spine register, ... -
Clinical implementation of novel diagnostic biomarkers for epithelial ovarian cancer - Can we improve diagnosis?
(2020-04-01)Background: Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer. The 5-year survival is about 30%, a consequence of failure to establish early diagnosis due to unspecific symptoms. The biomarker serum ... -
Invasive treatment for intermittent claudication - clinical outcomes and cost-effectiveness
(2020-04-01)Intermittent claudication (IC) is caused by obstructive arterial lesions and is characterized by effort-induced pain in the lower extremity, limiting walking distance, and reduced health-related quality of life (HRQoL). ... -
Femoroacetabular Impingement Syndrome - Outcomes of Arthroscopic Hip Surgery
(2020-03-27)Hip and groin problems are common among young, active individuals. Femoroacetabular impingement (FAI) syndrome is an important cause of hip pain and reduced hip function among these patients. Bony abnormalities at the ... -
Dizziness and Benign Paroxysmal Positional Vertigo among older adults - health-related quality of life and associated factors
(2020-03-10)Dizziness is a common complaint reported by more than 30% of persons over 70 years of age and accounts for 2% of all visits in healthcare annually. Benign paroxysmal positional vertigo (BPPV) is a common and treatable cause ... -
Transplantation of normal and decellularized syngeneic, allogeneic and xenogeneic cardiac tissue in mice and non-human primates
(2020-03-05)Introduction Because of the restricted inherent capacity of regeneration and healing, transplantation is the only treatment for end-stage heart failure but it has limitations of donor shortage and graft rejection. Cardiac ... -
Outcomes following primary total hip arthroplasty. With focus on the surgeon & surgeons' perceptions about feedback
(2020-03-05)Den övergripande målsättningen med det här avhandlingsarbetet var att utveckla en metodologi som förser ortopedkirurgen med information om sina egna resultat efter primär höftprotesoperation samt att undersöka effekterna ... -
Periprosthetic femoral fracture after total hip replacement. Incidence, risk factors, and treatment
(2020-02-18)This thesis investigates the incidence of surgically treated periprosthetic femoral fractures (PPFF) in Sweden between 2001 and 2011, the demography of this population, risk factors that may contribute to its occurrence ... -
Sex steroids, IGF-I, and vascular morphology from birth to adulthood in individuals born small for gestational age
(2020-02-11)Abstract Aim: To study whether there is an association between size at birth, sex steroids, IGF-I, and retinal vascular morphology. Patients and methods: Two different cohorts were studied. In paper I, 25 young adult men ... -
Translational studies of metastatic melanoma in the era of immunotherapy - from humanized mouse models to clinical trials
(2020-01-30)Immunotherapy with PD-1 inhibitors has transformed the treatment of met-astatic cutaneous mela- noma, and can lead to complete and durable responses in a proportion of patients. However, in around half of the patients, the ... -
Pain in Osteoarthritic Joints: Biological Signaling and 3D Models based on Imaging
(2019-12-19)Osteoarthritis (OA) is the most common joint disease, causing disability in middle-aged and elderly patients worldwide and imposing a huge socioeconomic burden. OA of the knee joint is a major cause of joint pain and, along ... -
Strain echocardiography in cardiac surgery - studies on the effects of loading conditions and inotropic agents on myocardial contraction and relaxation
(2019-12-19)Background: Although reductions in myocardial contractility and relaxation are key compo-nents in heart failure (HF), assessment of them is difficult, as clinical measurements deal with a net effect of myocardial contractility, ... -
Novel immunotherapies for metastatic melanoma - from mouse models towards clinical trials
(2019-12-06)Immunotherapies including checkpoint blockade and adoptive T cell transfer (ACT) show great promise for the treatment of melanoma, with long-term effects in some patients. However, around half of the patients with metastatic ... -
Development of methods and strategies for optimisation of x-ray examinations
(2019-11-29)The overall aim of the work presented in this thesis was to develop methods and strategies for the optimisation process prescribed by legal authorities for medical X-ray imaging. This overall aim was divided into four ... -
OVULATION: Intra-ovarian mechanisms
(2019-11-28)Background: Ovulation is the central biological process involved in the menstrual cycle of women. Specifically, ovulation involves the tissue remodelling of the preovulatory follicle to achieve the rupture of the exterior ... -
The Swedish Infant High-grade Reflux Trial - and a Focus group study of parents’ experiences
(2019-11-18)Background: Vesicoureteral reflux (VUR) is a pathological back-flow of urine from the bladder to the ureter and renal pelvis. VUR is associated with an increased risk of urinary tract infections (UTI) and renal damages. ... -
Intestinal preservation for transplantation: translational approaches
(2019-11-13)Background: Intestinal preservation injury (IPI) may result in various degrees of mucosal damage, which may later favor bacterial translocation, post-reperfusion syndrome, and upregulation of alloreactivity. Experimental ... -
Tonsil Surgery - Register Studies of Complications and Outcomes
(2019-11-07)Tonsillectomy is a commonly performed surgical procedure yet the evidence of the effect in patients with recurrent/chronic throat infections is unsatisfactory. Great variations exist in the reported rates of postoperative ... -
The use of fibrinogen in cardiac surgery patients-clinical and experimental studies
(2019-10-30)BACKGROUND Cardiac surgery with cardiopulmonary bypass impairs hemostasis due to hemodilution and consumption of platelets and coagulation factors, such as fibrinogen. The aim of this thesis was to study the role of ...