Doctoral Theses from Sahlgrenska Academy: Recent submissions
Now showing items 281-300 of 2013
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Strain echocardiography in cardiac surgery - studies on the effects of loading conditions and inotropic agents on myocardial contraction and relaxation
(2019-12-19)Background: Although reductions in myocardial contractility and relaxation are key compo-nents in heart failure (HF), assessment of them is difficult, as clinical measurements deal with a net effect of myocardial contractility, ... -
Life is doing. Facilitators and hindrances for occupational performance in adults with cerebral palsy - including methods of intervention
(2019-12-12)Introduction: Occupational performance is a complex process which poses difficulties to persons with CP even where they have relatively good motor function. Aim: To explore and describe the perception of occupational ... -
Changes in writing processes caused by post-stroke aphasia or low-grade glioma
(2019-12-11)Background: Writing is a cognitively and linguistically complex task, therefore sensitive to impairment caused by the presence and surgical removal of low-grade glioma or presence of post-stroke aphasia. Purposes: The ... -
Genome-wide epigenetic profiling of B cell leukemia and lymphoma
(2019-12-06)Epigenetic modifications, at the level of DNA methylation and post-translational modifications of histone tails cooperatively function in the organization of the genome, and thereby establish the gene expression profiles, ... -
Central actions of glucagon-like peptide-1 on food intake and reward: Novel neurological targets and sex divergent effects
(2019-12-06)Obesity is one of the biggest health risks of our society; however, treatment options are sparse and often result in suboptimal weight-loss. The glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) agonist liraglutide was ... -
Novel immunotherapies for metastatic melanoma - from mouse models towards clinical trials
(2019-12-06)Immunotherapies including checkpoint blockade and adoptive T cell transfer (ACT) show great promise for the treatment of melanoma, with long-term effects in some patients. However, around half of the patients with metastatic ... -
Patients and Staff in the Hybrid Operating Room: Experiences and Challenges
(2019-11-29)The hybrid operating room (OR), which combines a traditional OR with a radiological intervention room, is one example of the technical advancements within hospitals. In a hybrid OR, the staff have to manage the technique ... -
Development of methods and strategies for optimisation of x-ray examinations
(2019-11-29)The overall aim of the work presented in this thesis was to develop methods and strategies for the optimisation process prescribed by legal authorities for medical X-ray imaging. This overall aim was divided into four ... -
OVULATION: Intra-ovarian mechanisms
(2019-11-28)Background: Ovulation is the central biological process involved in the menstrual cycle of women. Specifically, ovulation involves the tissue remodelling of the preovulatory follicle to achieve the rupture of the exterior ... -
Experiencing life as migrants living with HIV in Sweden
(2019-11-27)The focus of this thesis is on the life situation of migrants living with HIV in Sweden. The overall aim of this thesis was to explore the knowledge of HIV-positive migrants’ life situation in Sweden, with a focus on health ... -
Cell cycle regulation in cancer: A noncoding perspective
(2019-11-26)The cell cycle progression is tightly regulated to ensure error-free cell replication. The complexity of the transcriptional machinery aids to function in a spatiotemporal pattern across different phases and genomic loci. ... -
Exercise in older adults with rheumatoid arthritis - a person-centred approach
(2019-11-20)Physical activity and exercise are well known to enhance health and are recommended as part of the management of rheumatoid arthritis (RA). However, the level of physical activity among older adults with RA is found to be ... -
Heart failure epidemiology with emphasis on young adults
(2019-11-20)Background: Heart failure (HF) is a major health problem worldwide with exponentially increasing incidence with age and the majority of patients being elderly. In recent years, an increase in hospitalization and prevalence ... -
Spinal mobility, muscle strength and function in patients with idiopathic scoliosis. Different aspects on long term outcome
(2019-11-19)Introduction: The long-term physical function outcome in patients treated for idiopathic scoliosis (IS) during childhood and adolescence has not been fully explored. In addition, there is a lack of studies where different ... -
Towards restoring intestinal health after pelvic radiotherapy - Lessons from dietary fiber intervention in a novel mouse model
(2019-11-18)Patients who have cancer in the pelvic region are at risk of developing gastrointestinal symptoms for weeks, months, or even years after receiving radiotherapy. These symptoms are triggered due to unwanted radiation-induced ... -
Health-Related Quality of Life and Growth Hormone Treatment
(2019-11-18)Introduction Growth Hormone (GH) is used to increase height in Turner Syndrome (TS), the most common sex-chromosome aberration in women. GH is also beneficial for bone mass. However, little is known about how GH treatment ... -
The Swedish Infant High-grade Reflux Trial - and a Focus group study of parents’ experiences
(2019-11-18)Background: Vesicoureteral reflux (VUR) is a pathological back-flow of urine from the bladder to the ureter and renal pelvis. VUR is associated with an increased risk of urinary tract infections (UTI) and renal damages. ... -
Taurine and dopamine-related effects of ethanol. An experimental study in rodents
(2019-11-18)The reinforcing properties of alcohol (ethanol) are associated with activation of the mesolimbic dopamine system and the concomitant increase in dopamine in the nucleus accumbens (nAc). Changes in this system are thought ... -
Body mass index and mental health in young people - predictors of early heart failure and cardiomyopathy
(2019-11-18)Heart failure among young people is rare, but in contrast to decreasing incidence rates overall, recent studies have found increasing rates among the young over the last decades. Concomitantly, cardiomyopathies, which ... -
In vitro models of the blood brain-barrier using iPSC-derived cells
(2019-11-18)The blood-brain barrier (BBB) constitutes the interface between the blood and the brain tissue. Its primary function is to maintain the tightly controlled microenvironment of the brain. Models of the BBB are useful for ...