Doctoral Theses from Sahlgrenska Academy: Recent submissions
Visas titlar 41-60 av 1864
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Obesity, weight reduction treatment and IVF
(2021-10-26)Background: Obesity is a growing problem on a global scale and women with obesity have a higher risk for infertility and complications, for both mother and child, in pregnancy and birth. This has been shown both regarding ... -
The Role of FCGBP in Mucus - Structure, Processing and Function
(2021-10-26)In this thesis, a bottom-up approach was used to study the IgG Fc-binding protein (FCGBP), which next to the MUC2 mucin is the second main component of secreted mucus in small intestine and colon. FCGBP is also found in ... -
Sex steroid secretion during childhood in males - with focus on prematurity, birth size, and growth patterns
(2021-10-21)Aim: The overall aim of the thesis was to evaluate sex steroid secretion patterns during childhood in boys and to study how sex steroid concentrations relate to gestational age, birth weight, growth patterns, and adult ... -
Aspects of Chemotherapy in Prostate Cancer
(2021-10-19)Since 2004 chemotherapy has been a part of standard of care in prostate cancer (PC) and improved symptom control and survival has been demonstrated in metastatic castration-resistant PC. Whether docetaxel has benefits in ... -
Humeral fractures - Epidemiology, treatment and reoperations in the Swedish Fracture Register
(2021-10-15)Fractures are common, but the knowledge on outcomes, treatment methods or the actual number of fractures treated each year has been sparse. With the introduction of the Swedish Fracture Register (SFR) in 2011, the prospective ... -
Cognition and activity early after stroke
(2021-10-13)Introduction and aims: Cognitive impairment and dependency in activities of daily living (ADL) are common consequences of stroke. Due to a decrease in the length of hospital stay, assessment of these conditions ... -
Computational studies of mutational sequence signatures in cancer genomes
(2021-10-08)Cancer typically forms when mutational processes modify key cancer driver genes, resulting in positive selection and tumor growth. As such, mutational processes are at the core of the disease. Trinucleotide mutational ... -
Periarticular changes in association with osteoarthritis in the hip, knee or shoulder
(2021-10-08)The aim of this thesis was to evaluate the presence of degenerative changes in the periarticular tendons in association with osteoarthritis (OA) in the hip, knee or shoulder. Moreover, changes in bone mineral density (BMD) ... -
On dental implant failure and patient-related factors
(2021-10-08)Dental implants function as anchorage for dental prostheses. In a small number of cases, osseointegration fails to establish or be maintained around the implants, but the reasons for these failures are not yet fully ... -
Mechanisms underlying inflammation, symptoms and quality of life in ulcerative colitis
(2021-10-06)A substantial proportion of patients with ulcerative colitis (UC) in remission demonstrate gastrointestinal (GI) symptoms, despite the absence of ongoing inflammation in the colon. The underlying mechanisms of these symptoms ... -
Effect of Probiotics on Caries-related Variables
(2021-10-05)In relation to the caries disease, the aims of this thesis were to investigate the effect of probiotic drops on different caries-related variables in vivo (Papers I & III), on interference capability and genetic response ... -
Adaptation of ventricular repolarization to heart rate change in humans
(2021-10-01)Background: Life-threatening cardiac rhythm disturbances and sudden death are common manifestations of heart disease. Disturbances in electrical recovery (ventricular repolarization; VR) are important mechanisms behind ... -
Predictors of survival in cardiac arrest
(2021-10-01)Cardiac arrest (CA) refers to the cessation of cardiac function. Survival is around 30% for in-hospital cardiac arrest (IHCA), and 10% for out-of-hospital cardiac arrest (OHCA). Many factors influence survival, ranging ... -
Neutrophil recruitment in periodontal disease
(2021-10-01)Neutrophils are the first immune cells to arrive in infected or injured tissues, where they engulf microbes and clean up cell debris. Periodontitis is one of the typical symptoms of both neutropenia and defect neutrophil ... -
lntrafractional motion effects during stereotactic body radiation therapy of lung tumors
(2021-09-24)Abstract: Patient shifts and tumor motions occurring during stereotactic body radiation therapy (SBRT) have been analyzed to determine the related effects on the delivered dose. Methods: 4-dimensional computed tomography ... -
Optimization of first-line anti-tuberculosis therapy in patients co-infected with HIV
(2021-09-24)Every year over one million people die from tuberculosis. People infected with HIV are significantly more vulnerable to tuberculosis, which is the leading cause of HIV-associated death. The first-line treatment for ... -
Vitamin D and Vitamin D-binding Protein in Psoriasis and Effects of Treatment
(2021-09-16)Background: Topical vitamin D analogues constitute an established treatment for psoriasis but the role of vitamin D in the pathogenesis of the disease remains controversial. The in loco production and immunomodulatory ... -
Aspects of bone quality and risk assessments in fracture and elective orthopaedic patients
(2021-09-15)Background: Bone quality, bone strength, and bone remodelling are important in many orthopaedic conditions and can have an impact on fracture incidence, bone healing, implant failure, and different outcome aspects. ... -
Cardiac arrest - an epidemiologic perspective on pharmacotherapy and post resuscitation care
(2021-09-13)Background: Despite significant research and progress, cardiac arrest remains a condition with a high mortality rate, and few interventions have been demonstrated to improve outcomes in this patient group. Despite incorporation ... -
Cardiovascular morbidity and metabolic signature in patients with rheumatoid arthritis
(2021-09-09)Background and objectives: Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease with excess risk for cardiovascular morbidity and mortality. The treatment of RA by anti-inflammatory drugs has dramatically ...