Doctoral Theses from Sahlgrenska Academy: Recent submissions
Now showing items 121-140 of 2013
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Alzheimer's disease and vascular dementia in population-based studies
(2021-03-30)Dementia, a clinical syndrome with several profiles and causes, is characterised by a decline in cognitive functions, including memory, learning, executive function, attention, language, and social ability. The most common ... -
Stent treatment of perforated duodenal ulcer - physiology and clinical aspects
(2021-03-30)Background The incidence of perforated duodenal ulcer is decreasing but still constitutes a life-threatening complication to peptic ulcer disease. Abdominal contamination from gastric or duodenal content occurs during ... -
Enriched, task specific therapy in the chronic phase after stroke
(2021-03-29)Recovery and improvement of motor functions and abilities after stroke depend on the spontaneous recovery process but also on the reorganization of neural mechanisms. In animal studies, an Enriched Environment (EE) has ... -
On chaperone co-operation in temporal and spatial protein quality control
(2021-03-29)In order for a protein to be able to function correctly it needs to adopt its proper fold. Because of this, protein quality control (PQC) is vital at every level of cellular function. The central protein in PQC networks ... -
Glycan dependent Helicobacter spp. and Streptococcus oralis binding to mucins in the gastric and oral mucosal niches
(2021-03-26)Helicobacter pylori infects the stomach of half of the world’s population, while Helicobacter suis colonizes pigs and is the most common non-H. pylori Helicobacter species that also infects human stomach. Infection with ... -
Cervical and vaginal cancer - aspects on risk factors, prevention and treatment
(2021-03-26)Background: Participation in screening is associated with a major risk reduction in cervical cancer, but there is a lack of knowledge on whether the cost to the individual has an effect on the participation rate. Women ... -
Characterization of secretory mechanisms in lacrimal and salivary glands
(2021-03-25)Dry mouth and dry eyes are multifactorial morbidities that can lead to a severely reduced quality of life. Approximately 20% of the population suffers from ocular or oral dryness. In the pursuit of pharmacological treatments ... -
Diabetes and hypertension - entangled chronic conditions in primary care. Time trends and determinants for mortality and cardiovascular complications.
(2021-03-23)Diabetes and hypertension are chronic, often coexisting conditions with increased risk of premature death and cardiovascular complications. This thesis aimed to study different epidemiological aspects regarding risk of ... -
Obesity in diabetes. Cardiovascular outcomes and risk factor trajectories
(2021-03-23)Introduction: The association between body mass index (BMI) and mortality in diabetes is complex and sparsely investigated for cardiovascular (CVD) outcomes. We aimed to investigate these relationships among patients ... -
Long-term radiobiological effects of 131I exposure - dose, age and time related transcriptomatic and proteomic rasponse in rats
(2021-03-23)131I is commonly used in the clinic for treating thyroid diseases, using the physiological uptake of iodine in thyroid, but also for other target tissues. 131I is also commonly released during nuclear accidents. Children ... -
Ultrasensitive DNA sequencing using liquid biopsies enables precision medicine
(2021-03-18)Liquid biopsies are minimally invasive and allow repetitive sampling of body fluids. Analysis of cell-free tumor DNA in liquid biopsies can be used as a biomarker for cancer. However, in most clinically relevant liquid ... -
Patient Assessment and Triage in Emergency Medical Services - The Swedish EMS nurse in a new role
(2021-03-16)Abstract Background: Pre-hospital care is highly complex care where the emergency medical services (EMS) nurse assesses patients in an unselected patient population. The increased demand for EMS resources, which ... -
Rectal Cancer and Quality of Life. Aspects on Communication and Patient Education
(2021-03-16)Background This thesis reports the results of three studies based on a pro-spective cohort study of an unselected population of patients with rectal cancer, and one study based on an exploratory study of a new patient ... -
Aspects of lung mechanics during mechanical ventilation
(2021-03-06)Background: One of the most common diagnoses in the intensive care unit is acute respiratory failure. In its most severe form it is called acute respiratory distress syndrome and often requires mechanical ventilation. The ... -
Microcirculation in tissue repair - from microsurgery to 3D bioprinting
(2021-03-03)Microsurgical reconstruction is challenged by two main shortcomings: Perfusion Related Complication (PRC) and donor site morbidity. In the first 3 studies of this thesis, we aimed to provide solutions to PRC-problems, ... -
Molecular insights into primer removal during mtDNA replication
(2021-03-01)Mitochondria are vital for cell survival, and the primary producers of ATP, the energy currency used for various metabolic processes. Mitochondria are unique from other cellular compartments ... -
Fetal Alcohol Spectrum Disorders in Children and Young Adults with an emphasis on ophthalmology
(2021-02-26)Introduction: Fetal alcohol spectrum disorders (FASD) are a group of disorders caused by prenatal alcohol exposure (PAE). The most severe and most studied FASD condition is fetal alcohol syndrome. Other conditions include ... -
Tissue engineering for novel female infertillity treatments: studies on small and large animal models
(2021-02-25)Introduction: As with any transplantation (Tx) procedure, uterus Tx is associated with risky donor surgery and adverse side-effects from immunosuppression. With the aim to bypass these risks, this thesis investigated uterus ... -
The role of head size in total hip arthroplasty - Dislocation, wear and cup stability
(2021-02-24)Large heads are used in total hip arthroplasty, with the aim of reducing the risk of dislocation, but there are concerns related to polyethylene wear, corrosion and cup loosening. Paper I is an observational study that ... -
The role of MBOAT7 on fatty liver disease
(2021-02-18)Non-alcoholic fatty liver disease (NAFLD) is the main health disorder in internal medicine, affecting one third of the population worldwide. Environmental and genetic factors contribute to NAFLD susceptibility and progression. ...