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dc.contributor.authorPagoldh, Maria
dc.date.accessioned2014-01-31T07:24:38Z
dc.date.available2014-01-31T07:24:38Z
dc.date.issued2014-01-31
dc.identifier.isbn978-91-628-8845-9
dc.identifier.urihttp://hdl.handle.net/2077/34071
dc.description.abstractComplementary Treatment and Markers in Inflammatory Bowel Diseases Maria Pagoldh Institute of Medicine, Department of Molecular and Clinical Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden Aims: The aims of this thesis were to evaluate potential prognostic markers and addition of complementary treatments in inflammatory bowel diseases. Background: Inflammatory bowel diseases, the two main types of which are ulcerative colitis and Crohn’s disease, affect nearly 1% of the Scandinavian population and implies a risk of a chronic progressive, disabling disease. When considering treatment options, issues are: pre-dicting short and long-term prognosis, selecting optimal treatment options and providing ap-propriate care for complications of the conditions or treatments. Methods: Selected variables were investigated to determine their ability to predict colectomy in an early phase of a severe attack of ulcerative colitis in patients admitted to hospital. Hy-perbaric oxygen treatment was tested as a complementary treatment in acute severe ulcerative colitis. Addition of supplementary treatment with cereals was evaluated in patients with se-quelae after intestinal resections. Results and Conclusions: Analyses of stool frequency, faecal weight and complement factor 3c in plasma may contribute to an early prediction of the disease course in a severe attack of ulcerative colitis. Hyperbaric oxygen treatment as a complementary treatment in a severe at-tack of ulcerative colitis does not improve clinical outcome. Specially processed cereals, as well as non-processed cereals, can be safely used in patients with previous intestinal resec-tions. Intake of non-processed cereals may decrease faecal volume in these patients. Key words: inflammatory bowel diseases, ulcerative colitis, Crohn disease, predictor, com-plementary therapies, hyperbaric oxygen therapy ISBN: 978-91-628-8844-2 http://hdl.handle.net/2077/34071 Gothenburg 2014sv
dc.language.isoengsv
dc.relation.haspartI. Pagoldh M et al. Faecal analysis and plasma complement factor 3c levels at admissionfor an acute attack of ulcerative colistis are predictive of the need for colectomy. Eur J Gastroenterol Hepatol. 2014 Jan 13. [Epub ahead of print] ::PMID::24418832sv
dc.relation.haspartII. Pagoldh M et al. Hyperbaric oxygen therapy does not improve the effects of standardized treatment in a severe attack of ulcerative colitis: a prospective randomized study. Scand J Gastroenterol 2013;48(9):1033-1040. Epub Jul 23. ::doi::10.3109/00365521.2013.819443sv
dc.relation.haspartIII. Pagoldh M et al. Effects of a supplementary diet with specially processed cereals in patients with short bowel syndrome. Eur J Gastroenterol Hepatol 2008;20:(11)1085-1093. ::doi::10.1097/MEG.0b013e328303c00asv
dc.subjectinflammatory bowel diseasessv
dc.subjectulcerative colitissv
dc.subjectCrohn diseasesv
dc.subjectpredictorsv
dc.subjectcomplementary therapiessv
dc.subjecthyperbaric oxygen therapysv
dc.titleComplementary treatment and markers in inflammatory bowel diseasessv
dc.typetexteng
dc.type.svepDoctoral thesiseng
dc.gup.mailmaria.pagoldh@vgregion.sesv
dc.type.degreeDoctor of Philosophy (Medicine)sv
dc.gup.originUniversity of Gothenburg. Sahlgrenska Academysv
dc.gup.departmentInstitute of Medicine. Department of Molecular and Clinical Medicinesv
dc.gup.defenceplaceFredagen den 21 februari 2014, kl 13.00, Aulan, Centralkliniken Sahlgrenska Universitetssjukhuset/Östra sjukhusetsv
dc.gup.defencedate2014-02-21
dc.gup.dissdb-fakultetSA


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