Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin: Recent submissions
Now showing items 221-240 of 322
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Embryonic ecdysone-induced gene expression and progression of organ morphogenesis
(2011-05-26)The formation of an epithelial organ requires a set of organ-specific gene programs that instruct parallel and successive developmental events. Still, it is unclear what are the core regulatory programs and how such programs ... -
Intracellular regulation of TLR signaling Basic mechanisms and importance in intestinal inflammation
(2011-04-21)Toll-like receptors (TLRs) recognize conserved structures on/in microorganisms. The intracellular signalling pathways of TLRs are shared with IL-1R and IL-18R and their activation leads to transcription of proinflammato ... -
Function of natural killer cells in Helicobacter pylori infection and gastric cancer
(2011-02-22)Helicobacter pylori infection is one of the most wide-spread infections in the world and causes a chronic inflammation in the gastrointestinal mucosa characterised by increased production of IFN-γ and is associated with ... -
From 1p3 to PI3K - Studies of neuroblastoma
(2011-01-19)Neuroblastoma (NB) is a tumor of the sympathetic nervous system and is the most common extra-cranial tumor of childhood, accounting for 7% of all pediatric malignancies. Despite recent advances in therapeutics, outcome is ... -
Geographic and genetic diversity of hepatitis B
(2011-01-04)Hepatitis B Virus (HBV) infection is a global health problem and may lead to chronic hepatitis, liver cirrhosis and hepatocellular cancer. The ability of HBV to adapt to the host environment by genetic variation has lead ... -
Evolution of protein and non-coding RNA genes studied with comparative genomics
(2010-12-16)The identification of protein and non-coding RNA (ncRNA) genes is one important step in the analysis of a genome. This thesis focuses on the identification and analysis of proteins and ncRNAs homologues by exploiting a ... -
Molecular mechanisms of embryonic stem cell pluripotency: transcription, telomere maintenance and proliferation
(2010-11-19)Somatic cell nuclear transfer and generation of induced pluripotent stem cells provide potential routes towards generation of patient specific embryonic stem (ES) cells. These procedures require induction of Oct4 gene ... -
Bacterial colonization of the neonatal bowel and ileal pouch with focus on E. coli
(2010-11-19)The colonic microbiota is a source of inflammatogenic and potentially pathogenic bacteria, but also a source of immune maturation signals to the infant. Here, we have investigated the normal colonic microbiota, with focus ... -
LEUKOCYTE RECRUITMENT TO HUMAN GASTROINTESTINAL TISSUES - STUDIES IN H. PYLORI-INDUCED GASTRITIS AND COLON ADENOCARCINOMAS
(2010-11-19)Chronic inflammation is a major pathological basis for tumor development and two examples are H. pylori infection of the stomach mucosa and inflammatory bowel disease, which are strongly associated with gastric and colon ... -
TGF-beta signaling in cancer
(2010-11-19)Transforming Growth Factor beta (TGF-beta) is a cytokine regulating a wide range of cellular processes such as proliferation, differentiation, and migration. At the early stages of cancer development TGF-beta functions as ... -
Mucosal adjuvants and their mode of action in the female genital tract
(2010-10-18)Sexually transmitted infections (STIs) cause a socioeconomic burden, morbidity and even mortality in a large part of the human population all over the world today. One of the most common genital ulcerative diseases is ... -
The immunomodulatory function of staphylococcal superantigen on oral tolerance
(2010-10-08)Exposure to soluble proteins via the gut gives rise to systemic tolerance, a phenomenon called oral tolerance. Failure of oral tolerance results in allergy, a disease that has increased during the last decades in Western ... -
Transcriptional profiling of human embryonic stem cells and their functional derivatives
(2010-10-07)Human embryonic stem cells (hESCs) represent populations of pluripotent, undifferentiated cells with unlimited replication capacity, and with the ability to differentiate into any functional cell type in the human body. ... -
Identification of stem cell factors - Novel protein-protein interactions and their functions
(2010-09-10)Embryonic stem (ES) cells provide an unlimited source of cells potentially useful for regenerative medicine, however, prior to clinical implementation, additional basic research is needed. This thesis is focused upon ... -
Embryonic origin and development of thyroid progenitor cells. An experimental study focused on endoderm, EphA4 and Foxa2
(2010-06-04)The thyroid gland consists of two endocrine cell types, the follicular cells that produce the thyroid hormones T3 and T4 and the parafollicular C-cells that synthesize calcitonin. It is well-known that these cells have ... -
HIV Persistence and Viral Reservoirs
(2010-05-28)Although antiretroviral therapy (ART) can effectively inhibit replication of human immunodeficiency virus type 1 (HIV-1), the virus is able to persist in cellular and anatomical viral reservoirs. Latently infected resting ... -
Foxf2 and Foxc2, two transcription factors that regulate adipocyte metabolism
(2010-05-28)Type 2 diabetes is the most common metabolic disorder today and has reached epidemic proportions in many countries. Diet-induced insulin resistance plays a central role in the development of type 2 diabetes. Studies included ... -
Computational analysis of oligosaccharide conformations – methodological development, applied studies, and design of glycomimetics
(2010-05-28)Carbohydrates are the most abundant class of biomolecules. Besides their roles as structural elements and energy storage, they are involved in signaling and recognition processes. Their functions and activities depend on ... -
On the Diagnosis and Management of Viral Respiratory Infections
(2010-05-28)Acute respiratory tract infections (ARTIs), are the most common infections in man, and represent a major global health burden. Viruses, most often causing a mild and self-limiting disease, yet with substantial morbidity ... -
Derivation, Characterization and Differentiation of Feeder-Free Human Embryonic Stem Cells
(2010-05-17)Human embryonic stem cells (hESCs) are pluripotent cells with self-renewal ability, derived from the inner cell mass of a human blastocyst. They have the remarkable potential to develop into different cell types and can ...