Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin: Recent submissions
Visas titlar 101-120 av 322
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Growth regulation in thyroid development
(2018-05-07)The fundamental aspects of developmental mechanisms that regulate embryonic and postnatal thyroid growth gaining the final size of the gland are still largely undetermined. In embryonic development, various organs and ... -
Targeting NOX2 in cancer
(2018-02-27)Reactive oxygen species (ROS) are short-lived, toxic derivatives of oxygen that are produced during mitochondrial respiration and by NADPH oxidases (NOX). By enzymatically generating ROS, the myeloid cell NOX2 plays a ... -
Comprehensive analysis of structural genomic alterations in cancer
(2018-02-13)The transformation of a normal cell into a cancer cell involves the accumulation of somatic DNA alterations that confer growth and survival advantages. These genomic alterations can be different in terms of pattern and ... -
Molecular aspects on Herpes simplex virus type 1 DNA replication and gene expression
(2017-12-22)Herpesviruses infect a variety of animals from molluscs to humans and they have evolved in a close relationship with their hosts. In humans, we find nine herpesviruses, representing all three subfamilies of the family ... -
Rotavirus and polymicrobial enteric infections and their short-term course in East African children
(2017-11-30)Diarrhoeal diseases in children under five years are the second leading cause of deaths in children worldwide, and especially in low-income countries in sub-Saharan Africa and in southern Asia where about 450,000 children ... -
Community onset sepsis in Sweden - a population based study
(2017-11-17)Sepsis and previously “severe sepsis” are concepts used for denoting organ dysfunction caused by acute infection. Organ dysfunction correlates to increased case fatality rates. Sepsis is a common cause of hospitalization. ... -
Characterizing the role of long non coding RNAs epigenetic regulators in disease model
(2017-11-17)Long non-coding RNAs (lncRNAs) are a class of biological molecules which are transcribed from DNA but are not translated into any protein. LncRNAs have been identified as critical players in gene regulation. Misregulation ... -
Impact of NK cell repertoires on immunotherapy in acute myelod leukemia
(2017-11-08)Natural killer (NK) cells are lymphocytes endowed with cytotoxicity against aberrant cells, including transformed and virus-infected cells. NK cell function is dictated by a fine-tuned interplay between activating and ... -
Genomic instability and genetic heterogeneity in neuroblastoma tumours
(2017-11-03)Javanmardi, N., 2017, Genomic instability and genetic heterogeneity in neuroblastoma Department of Pathology and Clinical Genetics, Institute of Biomedicine at Sahlgrenska Academy, University of Gothenburg, Sweden Neuroblastoma ... -
Infections associated with percutaneous osseointegrated titanium implants for limb prostheses
(2017-10-26)Femoral amputation is a devastating event. Percutaneous, bone anchored prosthetic systems reduce problems associated with socket suspended prostheses, but the design is inherently vulnerable to infection. The aims of this ... -
Epigenetic regulation of oncogenes and tumor suppressors in chronic lymphocytic leukemia
(2017-10-26)DNA methylation is one of the well-known epigenetic modifications. Aberrant DNA methylation has been shown to have a major role in tumorigenesis and is associated with tumor aggressiveness and inferior outcome in various ... -
Stem cells in the adult heart - 3D culture, isolation of side population cells and search for a stem cell niche
(2017-10-26)Cardiac tissue shows a poor regenerative capacity. From 2003 reports, mostly based on animal models, have showed existence of stem cells also in the heart. Using 14C measurements, a slow but steady turnover of the cardiac ... -
Exploring the heterogeneity of the hematopoietic stem and progenitor cell pool in cord blood
(2017-10-17)Hematopoietic stem cell transplantation (HSCT) is a curative treatment for a wide range of malignant and hereditary disorders. It is yet the only clinically established stem cell treatment. Hematopoietic stem and progenitor ... -
Natural killer T (NKT) lymphocytes regulate of intestinal tumor immunity
(2017-09-01)CD1d-restricted natural killer T (NKT) lymphocytes are known as potent early regulatory cells of immune responses, acting as a bridge between innate and adaptive immunity. While invariant NKT (iNKT) cells have a protective ... -
Measurement of sensitivity to DNA damaging agents
(2017-08-18)There is a large inter-individual variation in intrinsic sensitivity in patients receiving treatment with DNA damaging agents. Cancer therapy exemplifies this problem where patients experience varying degree of normal ... -
The role of fusion oncogenes and cancer stem cells in myxoid liposarcoma
(2017-08-07)Myxoid liposarcoma (MLS) is characterised by the FUS-DDIT3, or the less common EWSR1-DDIT3 fusion oncogene and is the second most common type of liposarcoma. The fusion oncogenes encode chimeric transcription factors that ... -
Oncogenic ALK signaling in neuroblastoma
(2017-05-15)Over the last decade Anaplastic Lymphoma Kinase (ALK), a receptor tyrosine kinase (RTK) has been identified as a translocation partner in diverse cancer types. In tumors, where the full-length ALK RTK itself is mutated, ... -
Glycoproteomics incursions into the realm of proteoglycans
(2017-02-09)The term proteoglycan encompasses a heterogeneous group of heavilymodified metazoan glycoproteins that are involved in fundamental biological processes. They are essential for embryonic development and play important roles ... -
Effects of biocides and metals on antibiotic resistance: a genomic and metagenomic perspective
(2017-01-10)Background and aim: There is a concern that biocides and metals can co-select for antibiotic resistance. The aim of this thesis is to enhance our understanding of the roles of antibacterial biocides (e.g. antiseptics, ... -
Human neutrophil heterogeneity: subsets, markers and autoantibodies
(2016-12-21)ABSTRACT Neutrophils are phagocytic white blood cells that play essential roles in innate im-munity and inflammation. Neutrophils have traditionally been viewed as a homog-enous cell population, where all cells carry the ...