Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin: Recent submissions
Now showing items 81-100 of 322
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Epigenetics of paediatric glioma stem cells; focusing on exosomes, miRNAs and DNA methylation
(2019-03-14)Tumours in the central nervous system are accountable for the majority of cancer-related deaths in children. Glioblastoma multiforme, one of the deadliest of the central nervous system tumours, is partly driven by glioma ... -
Small intestinal neuroendocrine tumours - Disease models, tumour development, and remedy
(2019-03-06)Small intestinal neuroendocrine tumours (SINETs) are malignant neoplasms which at the time of diagnosis often present with distant metastasis. The field of SINET research faces several challenges. There is a lack of ... -
Study the role of patient-specific mutations by genetic disease modeling
(2019-03-01)Many genetic diseases inherited in a dominant fashion have a complex pathological pattern. TOR1A mediated Dystonia-1 (DYT1) is an example of incomplete penetrance, affecting only a third of the carriers. DYT1 is an early-onset ... -
Regulatory T cells and mucosal-associated invariant T cells in colon adenocarcinomas; Phenotype and function
(2019-02-27)In many solid cancers, and also in colon adenocarcinomas, an increased accumulation of lymphocytes is beneficial for the patient. However, tumor-infiltrating immune cells may be either pro- or anti-tumorigenic and the ... -
Computational exploration of cancer genomes
(2019-01-09)Cancer evolves due to changes in DNA that give a cell an advantage at the expense of the remaining organism. These alterations range from individual base substitutions to broad losses or duplications of chromosomal material. ... -
Helicobacter spp. – host interaction in the mucus niche
(2018-11-30)Helicobacter pylori is the most common human gastric pathogen, colonizing half of the world's population. Helicobacter suis colonizes the stomach of 60-95% of pigs at slaughter age and it is the most prevalent non-Helicobacter ... -
Seroepidemiology of vaccine-preventable and emerging RNA viruses in Rwanda
(2018-11-28)Abstract Infectious diseases are a leading cause of death in sub-Saharan Africa, and in Rwanda diarrhea, lower respiratory and other common infections are linked to high mortality and morbidity. For children <5 years of ... -
Lung-resident, M2e-specific CD4 T cells critically protect during influenza infection
(2018-11-22)Memory CD4+ T cells are a critical component of the adaptive immune response to fight infection. However, current vaccines against influenza only focus on the other arm of adaptive immunity—triggering B cells to produce ... -
Broadly protective nanoparticle-based mucosal vaccine against influenza virus infection
(2018-11-12)Influenza is one of the major viral diseases affecting humans and it is responsible for three to five million cases of severe illness and about 250.000 to 500.000 deaths each year worldwide. A vaccine against pandemic ... -
Filamin A in Cardiovascular Remodeling
(2018-11-12)Filamin A (FLNA) is a large actin-binding cytoskeletal protein that stabilizes actin networks and integrates them with cell membranes. FLNA is therefore important for cell motility and organ development. We recently ... -
Immunotherapy and immunosuppression in myeloid leukemia
(2018-11-12)Acute myeloid leukemia (AML) and chronic myelomonocytic leukemia (CMML) are potentially life-threatening blood cancers characterized by the expansion of malignant myeloid cells in bone marrow and other organs. This thesis ... -
Early stage inflammation and cancer as reflected in the gastrointestinal mucus composition: implications for diagnosis, prognosis and pathogenesis
(2018-10-23)Mucus covers our inner interfaces towards the environment, providing protection while enabling vital interaction with the outside world. The mucus is built around mucin proteins, which are important for our defences against ... -
Colonic mucus structure and processing
(2018-10-05)The mucus layer covering the colonic epithelium creates a crucial first line of defense against the gut residing bacteria. Several lines of evidence suggest that a functional mucus layer is essential for health. For example, ... -
Redox reactions in cancer: impact and regulation
(2018-09-28)The reduction-oxidation (redox) reaction involves a change in the oxidation state of molecules where a molecule that donates an electron is oxidized and a molecule that accepts an electron is reduced. The NADPH oxidase of ... -
Epidemiology, molecular characterization of hepatitis viruses in Rwanda and implication on liver disease
(2018-08-20)Hepatitis viruses cause major health problems worldwide and, according to WHO, is the seventh leading cause of death globally. It is primarily hepatitis B and C virus that causes chronic hepatitis, liver damage and fibrosis, ... -
Genetic studies of the regulation of bone parameters and serum testosterone
(2018-05-29)Osteoporosis is a common disease characterized by low bone mass and microarchitectural deterioration of bone tissue leading to increased risk of fracture and represents a huge economic burden on health care systems. The ... -
Understanding the regulatory requirements for gut IgA B cell responses and their potential role in mucosal vaccine development
(2018-05-28)It is important to understand gut B cell differentiation, from the activation of cells at inductive lymphoid sites to the formation of gut plasma and memory B cell, to be able to develop efficient oral vaccines but the ... -
Effects of antioxidant supplementation on cancer progression
(2018-05-18)Popular wisdom holds that antioxidants protect against cancer because they neutralize reactive oxygen species (ROS) and other free radicals which can otherwise cause cancer by damaging DNA. This has been the rationale ... -
Origins of thyroid progenitors and tumor-initiating cells
(2018-05-14)The thyroid gland located in the anterior neck consists of two main cell types. First, the follicular cells that form the functional units, the follicles, in which thyroid hormones are produced and stored before release ... -
Dendritic cells and B cells in effector T cells decisions - promotion of antibody induction in lymphoid tissues or gut homing
(2018-05-14)Abstract CD4+ T cells are principal cells of the adaptive immune system, equipped with the ability to boost innate immune cells and aid B cells in the germinal centers. Every T cell clone carries a variable and unique T ...