Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin: Recent submissions
Now showing items 61-80 of 322
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Hepatitis B virus RNA in serum and liver tissue - quantification using digital PCR
(2019-12-19)Hepatitis B virus (HBV) infection is a global health issue that is responsible for approximately 900,000 deaths each year, by inducing liver cirrhosis and hepatocellular carcinoma (HCC). A few markers are used to classify ... -
Genome-wide epigenetic profiling of B cell leukemia and lymphoma
(2019-12-06)Epigenetic modifications, at the level of DNA methylation and post-translational modifications of histone tails cooperatively function in the organization of the genome, and thereby establish the gene expression profiles, ... -
Experiencing life as migrants living with HIV in Sweden
(2019-11-27)The focus of this thesis is on the life situation of migrants living with HIV in Sweden. The overall aim of this thesis was to explore the knowledge of HIV-positive migrants’ life situation in Sweden, with a focus on health ... -
Cell cycle regulation in cancer: A noncoding perspective
(2019-11-26)The cell cycle progression is tightly regulated to ensure error-free cell replication. The complexity of the transcriptional machinery aids to function in a spatiotemporal pattern across different phases and genomic loci. ... -
Towards restoring intestinal health after pelvic radiotherapy - Lessons from dietary fiber intervention in a novel mouse model
(2019-11-18)Patients who have cancer in the pelvic region are at risk of developing gastrointestinal symptoms for weeks, months, or even years after receiving radiotherapy. These symptoms are triggered due to unwanted radiation-induced ... -
Novel approaches to mucosal vaccine development Strategies in vaccine antigen production, construction of a novel mucosal adjuvant and studies of its mode of action
(2019-11-13)Although most infections begin at a mucosal surface and may be prevented by effective vaccine stimulation of the local mucosal immune system, there are so far only a few mucosal vaccines available for human use. This thesis ... -
Regulation of gut IgA induction by helper T cells
(2019-11-12)The gut is the largest lymphoid organ in the body. Due to intense and constant exposure to the outside world, it also functions as the most important portal of entry for many pathogens. T cell-dependent secretory immunoglobulin ... -
Hepatitis E virus in the virome of water and animals
(2019-11-12)This thesis was aimed to investigate viruses in different animals and water to get some understanding of viruses that disseminate into the environment. Next generation sequencing (NGS) was used to explore the virome from ... -
Understanding the role of long non-coding RNAs in neuroblastoma development and progression
(2019-11-11)Neuroblastoma (NB), a common cancer of childhood, contributes to 15% of all pediatric cancer deaths. The improper neuronal differentiation of neural crest cells to mature neurons in the sympathetic nervous system leads to ... -
Citrobacter rodentium and Escherichia coli interactions with mucus producing colonic epithelical cells
(2019-11-06)The epithelial cells together with the mucus layer protect the host from noxious luminal substances and pathogenic invasion. Pathogens have evolved numerous strategies to circumvent these barriers and mount infection. C. ... -
Gastrointestinal norovirus infections and the development of the next generation of mucosal vaccines
(2019-11-06)Human norovirus (HuNoV) is the causative agent of the winter vomiting disease and the leading cause of outbreaks of gastrointestinal infections across all settings and age groups in the world. The virus is highly contagious ... -
Next Generation Sequencing for Measurable Residual Disease Detection in Acute Myeloid Leukemia
(2019-10-30)Acute myeloid leukemia (AML) is the most common form of acute leukemia and generally associated with a poor prognosis. For both children and adults, the treatment is based on chemotherapy. Allogeneic hematopoietic stem ... -
Evaluation of fucosylated receptors for Cholera toxin in the human small intestine
(2019-10-22)Cholera toxin (CT) produced by Vibrio cholerae is the causative agent for the diarrheal disease cholera. Cholera is yearly afflicting millions and is estimated to kill over 100 000 people every year. In this thesis I aimed ... -
Herpesvirus infections in transplant recipients
(2019-10-21)Abstract Herpesvirus infections are common and can cause serious and life-threatening conditions in transplanted individuals. In this thesis, consisting of 4 papers (I-IV), we investigated primary infection and reactivation ... -
Candidatus Neoehrlichia mikurensis - a new agent of tick-borne infectious disease
(2019-09-06)“Candidatus Neoehrlichia mikurensis” (Ca. N. mikurensis) is a tick-borne bacterial pathogen that can cause disease particularly among immune compromised persons. This new infectious disease is called neoehrlichiosis. The ... -
Acute febrile illness in preschool children in Zanzibar - Infectious aetiologies, diagnosis and treatment
(2019-09-02)Background: A majority of the three million children in Africa that do not survive their fifth birthday die from infections that often start as a seemingly uncomplicated febrile illness. Primary health care workers ... -
Cell-based models for studying paediatric high-grade gliomas
(2019-05-06)Brain tumours are the largest group of solid tumours in children and accounts for most cancer-related deaths. Astrocytoma is the largest group, representing almost half of the brain tumours, where high-grade glioma is one ... -
Epidemiology of ESBL-producing E. coli with special reference to outbreak detection
(2019-04-30)Multidrug resistant bacteria, particularly extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae (EPE), are becoming a major health concern. ESBL-producing Escherichia coli (ESBL-E. coli) is the most prevalent ... -
Ischemic Stroke Outcomes - Analyses of Protein and Genetic Biomarkers
(2019-04-18)The overall aim of this thesis was to identify novel biomarkers for ischemic stroke outcomes. The specific aims were to test the hypotheses that circulating concentrations of hemostatic biomarkers predict the long-term ... -
Invasive fungal disease in immunocompromised hosts with focus on diagnostics
(2019-04-12)Invasive fungal diseases (IFDs) are severe conditions affecting immunocompromised patients. The primary aim of this thesis was to explore different methods for diagnosis of IFD in different groups of immunocompromised ...