Doctoral Theses / Doktorsavhandlingar Institutionen för medicin: Recent submissions
Now showing items 441-460 of 570
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Atrial fibrillation – on its trigger mechanisms, risks and consequences
(2010-05-11)Background: Atrial fibrillation (AF) frequently impairs quality of life, but in long-term it is associated with an increased morbidity and mortality. Persistent AF may cause changes in the sinus node function, and if ... -
Mechanical circulatory support in patients with severe heart failure
(2010-05-11)Severe heart failure has a poor prognosis. Mechanical circulatory support (MCS) is capable of assisting the circulation in selected patients to bridge them to heart transplantation or recovery of heart function. MCS is ... -
Passive sampling of PAHs and some trace organic compounds in occupational and residential air: needs, evaluation and limits
(2010-05-11)Human exposure to elevated levels of polycyclic aromatic hydrocarbons (PAHs) and trace organic compounds (e.g. PCB, OCP, PBDE) can be related to negative health effects. This raises demands of exposure measurements to be ... -
Modulatory role of IL-17 in airway inflammation
(2010-05-11)IL-17 orchestrates the accumulation of neutrophils to sites of infection and the release of microbicidal substances, and therefore plays a critical role in the innate immune response to infection. IL-17 is also involved ... -
Tenomodulin, serum amyloid A and the serum amyloid A receptor selenoprotein S – implications for metabolic disease
(2010-05-11)Obesity and obesity-related metabolic diseases are associated with a low-grade inflammation, including slightly increased serum levels of the acute phase protein serum amyloid A (A-SAA). A-SAA is one amongst several ... -
Regulation of IL-6-signaling and inflammatory response – Role of insulin, FOXO1 and PKCδ
(2010-04-27)The aim of this thesis was to investigate if and how insulin antagonizes interleukin-6 (IL-6)-signaling and action using both 3T3-L1 mouse adipocytes (Paper I) and HepG2 human hepatocytes (Paper III). We also investigated ... -
Leadership in human service organisations: Conceptions, strategies and preconditions to promote and maintain health at work
(2010-04-21)The aim of this thesis was to deepen knowledge of leaders’ conceptions, strategies and preconditions to promote and maintain health at work in human service organisations. Methods: The qualitative study I and prospective ... -
The role of physical activity on bone density and bone geometry in men
(2010-04-14)THE ROLE OF PHYSICAL ACTIVITY ON BONE DENSITY AND BONE GEOMETRY IN MEN Introduction: Several studies indicate that peak bone mass, reached during the third decade in life, is an important determinant of osteoporosis later ... -
Diffuse large B-cell lymphoma – studies on immunohistochemical and clinical prognostic factors
(2010-04-14)DLBCL, the most common lymphoma entity, is a potentially curable but heterogeneous disease. Most studies concerning therapy and prognostic factors have been performed on selected patient materials. It is important to ... -
Urinary Clara cell protein and alpha 1-microglobulin – biomarkers of changes in kidney and airway function
(2010-04-13)Validated biomarkers are useful tools for screening large populations. The benefit of screening may be improved risk assessment or early indications of adverse effects before detection or onset of symptoms. Screening is ... -
The Role Of Serum Amyloid A In Inflammatory Disease - Proinflammatory Mediator Or Inert Biomarker?
(2010-03-31)Abstract: Neutrophils are phagocytes of the innate immune system with prominent roles in host defense and are also believed to be important in autoimmune diseases such as rheumatoid arthritis (RA) by accumulating in inflamed ... -
Fibrinogen and Bleeding in Cardiac Surgery: Clinical Studies in Coronary Artery Bypass Patients
(2010-03-05)Fibrinogen and Bleeding in Cardiac Surgery: Clinical Studies in Coronary Artery Bypass Patients Background: Cardiac surgery is accompanied by inflammatory activation and bleeding complications. Fibrinogen is a key ... -
Weight loss studies in obese patients. Aspects of very-low-energy diet treatment and effects of obesity surgery on disability pension
(2010-03-02)Obesity is associated with increased risk of serious medical conditions, impaired quality of life, reduced working capacity, and shortened life expectancy. Obesity surgery is the most effective weight loss treatment with ... -
Gastric electrical stimulation. Studies in patients with intractable nausea and vomiting
(2010-03-02)The most severe cases of gastroparesis are refractory to drugs. In the 1990s gastric electrical stimulation (GES) was introduced for treatment of nausea and vomiting in patients with diabetic and idiopathic gastroparesis. ... -
On the regulation of immune responses to dietary and self antigens
(2010-02-04)Regulatory mechanisms are necessary to avoid the misdirected aggressive immune responses responsible for the pathology seen in autoimmunity and allergy. Thymic-derived CD4+CD25+ regulatory T cells are indispensible for ... -
Phenotype and function of CD25+ regulatory T cells in infants and adults
(2010-01-26)Active suppression by CD4+CD25+FOXP3+ regulatory T cells (Treg) is essential for the maintenance of peripheral tolerance to both self antigens and environmental antigens. Absence of these cells in human newborns leads to ... -
Molecular mechanisms behind the liver-induced acceptance of renal grafts in highly sensitized patients
(2009-12-18)Preformed antibodies directed at donor HLA are considered an absolute contraindication for kidney transplantation, because of the high risk of rejection. Thus, patients with high levels of HLA antibodies have little chance ... -
Epidemiology of heart failure and feasibility of home care in patients with worsening chronic heart failure
(2009-11-26)Aim: To investigate gender-specific trends in long-term mortality in patients hospitalised for ischaemic and non-ischaemic heart failure (HF) and explore temporal trends in the risk of HF complicating acute myocardial ... -
Therapeutic dendritic cell vaccination against human papillomavirus
(2009-11-19)Cervical cancer, which is caused by infection with human papillomavirus (HPV), is the second most common cancer among women worldwide, leading to 230000 deaths annually. The two currently available HPV vaccines can only ... -
Porcine myocardial ischemia-reperfusion studies on cardioprotection, ventricular arrhythmia and electrophysiology
(2009-11-19)Background: Coronary artery disease is the primary cause of death in adults in the industrialised world and ventricular fibrillation associated with myocardial ischemia is the main cause of sudden cardiac death. Restoration ...