Doctoral Theses / Doktorsavhandlingar Institutionen för medicin: Recent submissions
Visas titlar 301-320 av 570
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Intermittent claudication - studies on clinical evaluation strategies and invasive treatment efficacy
(2014-05-15)Peripheral arterial disease is a common health problem that globally affects over 200 million individuals, and intermittent claudication (IC) is the most common symptomatic presentation. The leg symptoms in IC are provoked ... -
Utmattningssyndrom, identifikation, karakteristika och förlopp
(2014-05-09)Aim. The overall aim of the thesis was to study exhaustion disorder (ED) with respect to identification, characterisation and course of illness, as well as some properties of an instrument of self-rated ED (s-ED). Method. ... -
Juvenile Chronic Arthritis: From Childhood to Adolescence and Adulthood
(2014-05-06)Juvenile chronic arthritis (JCA) is characterized by arthritis and onset before 16 years of age and of unknown etiology with an annual incidence between 7 and 23/100,000 in the Nordic countries. Several studies report ... -
Diagnostic aspects of urinary tract infections among elderly residents of nursing homes
(2014-05-05)Background: Up to half the residents of nursing homes for the elderly have asymptomatic bacteriuria (ABU), which should not be treated with antibiotics. Thus, it is difficult to know if new symptoms in residents with ... -
The susceptibility to metabolic and proliferative diseases - from genetic predisposition to treatment
(2014-05-05)Obesity and type 2 diabetes increase the risk of cardiovascular disease. Insulin resistance is highly correlated to type 2 diabetes and both obesity and insulin resistance are risk factors for cancer. Bariatric surgery is ... -
Economic impact of drug-related morbidity in Sweden - Estimated using experts’ opinion, medical records and self-reports
(2014-05-05)Drug-related morbidity is an important public health concern, but knowledge about its economic impact is limited to hospitals. Thus, important consequences to the general public may have been overlooked. The aim of the ... -
Molecular genetics of patatin-like phospholipase domain-containing 3 and chronic liver disease
(2014-04-30)Chronic liver disease is a major health burden worldwide. Major determinants of this condition are viral infections, alcohol abuse and obesity. Genetic background modulates the effect of damaging agents on the liver. The ... -
Hutchison-Gilford Progeria Syndrome – A new treatment strategy and the role of prelamin A in oncogenesis
(2014-04-25)Prelamin A, a CaaX-protein is a key structural protein of the inner nuclear lamina, a meshwork lining the inner nuclear envelope. Farnesylated prelamin A is cleaved just upstream of the farnesylcysteine residue to ... -
Estrogen and 2-methoxyestradiol: regulation of arthritis, inflammation and reactive oxygen species
(2014-04-25)Rheumatoid arthritis (RA) is characterized by severe synovial inflammation, cartilage destruction, and immune-mediated bone loss. Estrogen ameliorates experimental RA, reducing both inflammation and bone loss. The inflamed ... -
Non-functioning pituitary tumours - mortality, morbidity and tumour progression
(2014-04-16)Non-functioning pituitary tumours, i.e. non-functioning pituitary adenomas (NFPA) and craniopharyngiomas (CP), are histologically benign brain tumours. They are, however, associated with hypopituitarism, diabetes insipidus ... -
High Blood Pressure - Determinants and Risks
(2014-04-15)Aim: The overall aim of this thesis was to study determinants and risks associated with increasing blood pressure categories based on a combination of systolic and diastolic blood pressure ranging from optimal blood pressure ... -
Sleep disorders, sleepiness and the risk of traffic accidents
(2014-04-10)The aim of this thesis was to identify the prevalence of sleep disorders, mainly obstructive sleep apnea (OSA), among public transport operators (PTO´s). Further to assess the risk of motor vehicle accident (MVA) in a group ... -
Biomonitoring of Cadmium - Relationship between Cadmium in Kidney, Blood and Urine, Interpretation of Urinary Cadmium, and Implications for Study Design
(2014-04-04)Cadmium is an environmental contaminant which accumulates in the kidney and can potentially affect human health at relatively low concentrations. Biomarkers such as cadmium in urine or blood are normally used to assess ... -
T cell subsets in asthma and allergy - role of glucocorticoids, plasticity and microRNA-155
(2014-03-28)The focus of this thesis is the different subsets of CD4+ T cells involvement in asthma and allergy. It encloses studies of asthma and allergy in both humans and mice. The work of the three papers has been performed ... -
Defining orellanine as treatment of advanced renal cell carcinoma
(2014-03-28)Renal cancer causes over 100,000 annual deaths worldwide, and the incidence is increasing. Clear cell renal cell carcinomas (CCRCC), constituting 75% of renal cancer, are known for their high metastatic frequency and ... -
Biological relevance and prognostic significance of radial artery intima-media thickness
(2014-03-14)Cardiovascular disease (CVD) is the major cause of death both in Sweden and globally. Atherosclerotic vascular changes are considered the major underlying pathology leading to clinical manifestations of CVD, e.g. myocardial ... -
Life style intervention in primary care and aspects on stroke prevention
(2014-03-13)ABSTRACT Aims: To describe a self-administered preventive tool dealing with risk factors for cardiovascular disease and its effectiveness to involve persons in need of life style changes. To evaluate the feasibility of ... -
DIAVIP - Diabetes Prevention in Primary Care - Implications for Physical Activity
(2014-03-07)Aim: The overall aim was to study the effect of physical activity in impaired glucose tolerance (IGT) and insulin resistance. We set out to: 1. Evaluate different screening instruments to identify individuals with IGT; ... -
Linking fms-like tyrosine kinase 3 and urokinase signalling to survivin expression in experimental arthritis
(2014-03-07)Rheumatoid arthritis (RA) is a systemic autoimmune joint disease, in which chronic inflammation and hyperplastic synovial tissue mediates destruction of cartilage and bone. Survivin is known as an intracellular inhibitor ... -
Prevalence and nature of adverse drug events and the potential for their prevention - Population-based studies among adults
(2014-02-28)Background: Adverse drug events (ADEs) are common and often preventable in hospitals, but few studies have investigated ADEs in outpatient care and none addressed this issue in the general population. Aim: The aim of the ...