Doctoral Theses / Doktorsavhandlingar Institutionen för medicin: Recent submissions
Now showing items 121-140 of 570
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Isolation Strategies and Proteomic Characterization of Extracellular Vesicles
(2019-03-15)“Extracellular vesicles” is the collective term used to describe vesicular entities that are released from cells into the extracellular environment. These vesicles are composed of a delineating lipid membrane and its cargo ... -
Intimate partner violence, sociodemographic factors and mental health among population based samples in Sweden
(2019-03-13)Aims: To explore the prevalence of Intimate Partner Violence (IPV) and its association with sociodemographic factors, symptoms of depression, perceived need for mental care and primary health care utilization. Another ... -
Childhood Body Mass Index and Pubertal Timing - Changes over time and associations with adult cardiovascular mortality
(2019-02-21)Puberty in boys has long been an under-investigated area of research mainly due to the lack of an easily available pubertal marker, corresponding to menarche for girls. Using a unique, large, population-based cohort, ... -
Aspects of cost-effectiveness and feasibility of implementations for care of depressed persons in primary care - internet-based treatment and care manager organisation
(2019-01-18)Background: Depression is a major source of human suffering and a growing challenge for societies worldwide. The lion’s share of depressed persons in Sweden are diagnosed and treated in primary care. There is an urgent ... -
Androgen receptor signaling mechanisms in bone
(2018-12-13)Osteoporosis is a common age-related disease that increases the risk of fractures. Androgens are crucial for bone health in males. Although a substantial part of the effects of androgens on the skeleton is mediated via ... -
The Role of Estrogen Receptor α Signaling in the Regulation of Bone Mass
(2018-12-06)Estrogens are major regulators of skeletal growth and maintenance in both females and males. Estrogen receptor α (ERα) is the main mediator of estrogenic effects in bone. Thus, estrogen signaling via ERα is a target for ... -
Brain-Gut Interactions in Irritable Bowel Syndrome (IBS)
(2018-12-04)Irritable bowel syndrome (IBS) is a common disorder of gut-brain interaction defined by recurrent and longstanding abdominal pain and disturbed bowel habits. This thesis aims to deepen the knowledge about aberrant visceral ... -
Vitamin A and Bone: Studies in vivo and in vitro
(2018-11-28)Background: Excess vitamin A is associated with decreased cortical bone and increased risk of fractures in humans. The aim of the present thesis was to assess the importance of vitamin A on the skeleton and bone cells in ... -
Epidemiological studies in de novo and secondary acute leukemia
(2018-11-23)Abstract Background Acute leukemia (AL) is a rare blood cancer with poor prognosis in adult patients. Socioeconomic factors are known to impact cancer outcomes, but have not been adequately examined among adult AL patients. ... -
Platelet activation and aggregation: Clinical and experimental studies
(2018-11-21)Background: Dual antiplatelet therapy with acetylsalicylic acid (ASA) and the adenosine diphosphate (ADP)-receptor antagonist ticagrelor increases the risk of bleeding complications during cardiac surgery. The overall aim ... -
Health hazards and cancer in relation to occupational exposures among Swedish seafarers
(2018-11-19)This thesis explores health hazards for seafarers in the Swedish merchant fleet, and occupational risks for lung cancer, mesothelioma and hematologic malignancy (HM). A special focus has been exposure to benzene and biomarker ... -
Defining the importance of protein geranylgeranylation in innate immunity
(2018-11-19)RHO family proteins and other intracellular proteins are prenylated with a 20-carbon lipid—a product of the cholesterol synthesis pathway—by protein geranylgeranyltransferase type I (GGTase-I). Prenylation is widely believed ... -
Abdominal Aortic Aneurysm, aspects on diagnosis and treatment
(2018-11-16)Background An abdominal aortic aneurysm (AAA) is an abnormal widening of the aorta with a risk of rupture if it grows to a large diameter. Rupture ... -
Adherence to lipid-lowering medications and cardiovascular disease prevention in type 2 diabetes mellitus
(2018-11-07)Background and aims: Globally, cardiovascular disease (CVD) is the major cause of death among patients with type 2 diabetes mellitus (T2DM). Improved control of LDL cholesterol with lipid-lowering medications and patients’ ... -
Diffuse large B-cell lymphoma - proteomic and metabolomic studies on prognosis and treatment failure
(2018-11-05)Abstract Background and aim: Every year almost 600 patients in Sweden are diagnosed with diffuse large B-cell lymphoma (DLBCL), the most common lymphoma, and with immunochemotherapy, approximately 60 % are cured. Yet, for ... -
Host-Virus Interactions in Asthma and COPD
(2018-10-26)Asthma and chronic obstructive pulmonary disease (COPD) are associated with periods of worsened symptoms, known as exacerbations. Severe exac-erbations can result in hospitalisation, irreversible decline of the disease and ... -
Women's and Men's Health care utilisation from a cost perspective
(2018-10-23)The aim of this thesis was to explore sex differences in health care utilisation and costs (i) in a region in Sweden, (ii) in treatment of dialysis patients across the region, and (iii) in the treatment of specified ... -
Nutritional metabolomics: The search for dietary exposure variables
(2018-10-19)To establish associations and causation between diet and health, objective and reliable methods are needed to measure dietary exposure. Metabolomics provide an unbiased tool for exploring the modulation of the human ... -
Vitamin D in Somali women living in Sweden
(2018-10-02)Introduction: Sunlight is the major source of Vitamin D synthesis. Information regarding vitamin D, bone status and general health in Somali women living in Sweden is limited. Vitamin D binding protein (DBP) is the major ... -
Epidemiological aspects of cardiovascular morbidity and mortality among individuals with diabetes: the relative importance of cardiovascular risk factors
(2018-09-21)Background: Long-term trends of cardiovascular complications and death among patients with diabetes have not been studied extensively. In addition, we aimed to examine the effect of multifactorial risk factor control, as ...