Doctoral Theses / Doktorsavhandlingar Institutionen för medicin: Recent submissions
Now showing items 261-280 of 570
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Immune regulation by selective estrogen receptor modulators
(2015-04-30)At menopause, the levels of estrogen decline, leading to loss of estrogen-mediated protective effects on bone and an increased risk of osteoporosis. Hormone replacement therapy, containing estrogen, has been used for many ... -
Clinical relevance of high-sensitive Troponin T in cardiovascular disease
(2015-04-13)Background and aims: Troponin T (hs-cTnT) is a cardiac damage marker used in the diagnosis of non-ST segment elevation myocardial infarction (NSTEMI) and for prognostic assessment. Clinical decision-making should ideally ... -
Food allergy in adults
(2015-04-08)The knowledge on adverse reactions to foods and the spectrum of food-related gastrointestinal symptoms in relation to allergy in adults is still scarce. The conventional allergy tests do not always offer with precision ... -
Bone density, bone geometry and bone development in young men - the importance of pubertal timing and fracture history
(2015-03-30)Background and objective: Peak bone mass, the maximal bone mass attained in young adulthood, is an important factor of the lifetime risk of developing osteoporosis. The aim of this thesis was to study the development of ... -
Aspects of work and health in women with fibromyalgia
(2015-03-13)Fibromyalgia (FM) is characterized by persistent widespread pain, increased pain sensitivity and tenderness. FM is also associated with fatigue, psychological distress, impaired physical capacity, activity limitations and ... -
Susceptibility to chronic liver disease
(2015-03-06)The onset and the progression of chronic liver disease involve environmental and genetic factors. Hepatic stellate cells (HSCs) are important players in these processes and are the main storage site for retinol. We studied ... -
Evaluation of regression methods for log-normal data - linear models for environmental exposure and biomarker outcomes
(2015-03-03)The identification and quantification of associations between variables is often of interest in occupational and environmental research, and regression analysis is commonly used to assess these associations. While exposures ... -
Genes, lifestyle and coronary heart disease risk-epidemiological interaction studies
(2015-03-03)Coronary heart disease (CHD) has multifactorial background involving both genetic and lifestyle factors, but much is still unknown about their interactions. The aim of this thesis was to study interactions focusing on ... -
WISP-2 - A Novel Adipokine Related to Obesity and Insulin resistance
(2015-02-27)Type 2 diabetes mellitus (T2D) is increasing worldwide at an epidemic rate and is expected to reach 592 million inflicted individuals by 2035 as compared to 382 million in 2013. Obesity is a major risk factor for insulin ... -
Pre-Hospital Decision Process and Prognosis in Men and Women with Coronary Heart Disease
(2015-02-27)The overall aim of this thesis was to describe experiences, strategies and actions in the prehospital phase among patients with a first acute myocardial infarction and to examine long-term trends in survival among patients ... -
Mortality and morbidity in patients with Addison's disease
(2015-02-27)Addison's disease (AD) or primary adrenal insufficiency is a rare disease with an estimated prevalence of 100-140 per million inhabitants and deadly unless treated with glucocorticoids (GCs). Very limited information is ... -
Vascular and metabolic effects of selective PDE-5 inhibition - clinical and experimental studies
(2015-02-13)ABSTRACT Vascular and metabolic effects of selective PDE-5 inhibition Clinical and experimental studies Lovisa Sjögren Department of Molecular and Clinical Medicine, Institute of Medicine at Sahlgrenska Academy, ... -
Interaction of genetic susceptibility and traffic-related air pollution in cardiovascular disease
(2015-01-28)This thesis aimed at investigating gene-environment interaction in cardiovascular disease (CVD). A study population of 618 coronary heart disease (CHD) cases (of which 192 first-time acute myocardial infarction (AMI) ... -
Approaches to ensure and improve quality at primary healthcare centres - a study of the effects of a structured patient-sorting system and a healthcare reform
(2015-01-09)Background: Primary healthcare in Sweden meets increased demands from an aging population concerning quality and accessibility while dealing with a growing shortage of general practitioners and imperfect efficiency. ... -
Food-related gastrointestinal symptoms, nutrient intake and dietary interventions in patients with irritable bowel syndrome
(2015-01-09)Food is a recurrent problem in irritable bowel syndrome (IBS) and it is common to exclude foods, which could lead to a reduced nutrient intake. Perceived food intolerance is very common in IBS, but if specific or more ... -
Studies of Neutrophilic Inflammation in Tobacco Smokers
(2014-12-04)Studies of neutrophilic inflammation in tobacco smokers Kristina Andelid Department of Internal medicine and clinical nutrition, Institute of Medicine Sahlgrenska Academy at University of Gothenburg Göteborg, ... -
Primary open angle glaucoma in Nepal: Exploring the unknown
(2014-12-03)Background: Dealing with blindness related to primary open angle glaucoma (POAG) has always been challenging due to late detection as POAG can remain asymptomatic until end stage. Most eye hospitals in Nepal conduct ... -
Clinical and Population-based Studies in Multiple Myeloma and Monoclonal Gammopathy – Focus on Infections
(2014-12-03)Multiple myeloma is a haematological disorder of the bone marrow. It is preceded by the benign precursor monoclonal gammopathy of undetermined significance (MGUS). In multiple myeloma, a progression leading to expansion ... -
Parental time pressure and financial stress - Challenges for mental health of Nordic children and adolescents
(2014-12-02)Mental health problems are a significant public health concern affecting approximately 10-20% of children and adolescents worldwide. Parents’ conditions and experiences are important in determining children’s circumstances, ... -
Psychosocial work conditions - cardiovascular disease, perceptions and reactive behavior
(2014-12-01)The overall aims of this thesis were to improve our understanding of (1) associations between adverse psychosocial work conditions and less explored cardiovascular outcomes, and (2) workers’ perceptions and reactive behaviour ...