Doctoral Theses / Doktorsavhandlingar Institutionen för medicin: Recent submissions
Now showing items 81-100 of 570
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Cardiac arrest with emphasis on comorbidity and choice of treatment in acute coronary syndrome in the elderly
(2020-05-07)Background and aim: More data is required on survival and neurological outcome after in-hospital cardiac arrest (IHCA) in the elderly. The influence of comorbidity is often neglected in cardiac arrest research, particularly ... -
Development and dynamics of the normal gut microbiota
(2020-05-05)Altered gut microbiota configurations have been linked to human diseases. To identify mechanistic links between altered gut microbiota and disease states, definitions of the healthy gut microbiota need to be established. ... -
Understanding the molecular mechanisms of bile acid receptor activation for the treatment of human liver disease
(2020-04-30)Farnesoid X receptor (FXR) is a nuclear transcription factor that is activated by bile acids and regulates bile acid homeostasis, glucose and lipid metabolism. FXR activation by a ligand has been identified as a therapeutic ... -
Decellularization as a method to generate a new generation of vascular grafts
(2020-04-29)Decellularization of blood vessels is a technique to remove cells from the extracellular matrix (ECM), which can be used as a vascular graft for peripheral or coronary blood vessel bypass surgery. This thesis focuses on ... -
Congenital Heart Disease, Type 1 and Type 2 Diabetes Mellitus
(2020-04-28)Worldwide, 1% of all live born children are born with a congenital heart disease (CHD) and currently >95% reach adulthood due to better diagnostics and medical care. At the same time, Diabetes Mellitus (DM), type 1 (T1DM) ... -
Investigating the role of Class-1 Phosphoinositide 3 Kinases (PI3Ks) in insulin signaling and obesity
(2020-04-28)Obesity and obesity related diseases such as type 2 diabetes, cardiovascular disorders, and different types of cancer are leading causes of mortality and morbidity in modern society. However, the mechanism that links obesity ... -
Cardiovascular disease in patients with congenital heart disease
(2020-04-23)Background: Today, about 95% of children with congenital heart disease (CHD) survive into adulthood and the survival in patients with CHD has increased considerably during the last decades. With increasing age, patients ... -
Aspects of heart failure development and prevention in women
(2020-04-15)Heart failure (HF) is a severe progressive condition. Women more often are older and suffer from heart failure with preserved ejection fraction (HFpEF), contrasting to men who more often are younger and suffer from heart ... -
Immunological, vascular and metabolic actions of androgens
(2020-03-10)Men have higher prevalence of cardiovascular disease (CVD) but lower risk of autoimmune disorders than women. The actions of sex steroids may be involved in the sexual dimorphism of these diseases. Although testosterone, ... -
Prevalance and prevention of sexually transmitted viral infections in the Bolivian Amazonas
(2020-03-05)This thesis investigates the prevalence of sexually transmitted viral infections in women living in the Amazonas region of Bolivia and explores whether Bolivian medical plants can affect the immune system and prevent or ... -
Socioeconomic aspects of lifestyle and women's health: a primary care and population perspective
(2020-03-05)Aims: To estimate growth characteristics and socioeconomic factors in relation to over-weight/obesity among 4-year-old children. To explore whether a primary care lifestyle programme reached and engaged socioeconomically ... -
Cardiovascular outcomes and extra-articular manifestations in patients with spondyloarthritis
(2020-02-27)Background: Spondyloarthritis (SpA) is a cluster of rheumatic diseases with similar clinical features, including association with extra-articular manifestations such as anterior uveitis (AU), inflammatory bowel disease ... -
Outcome of Graves disease
(2020-02-05)Graves' disease (GD) is an autoimmune condition with elevated thyroid hormone levels and symptoms suggesting an affected brain. These symptoms often resolve with treatment but, for some patients, GD results in a long period ... -
Epidemiological Aspects on Assessing and Treating Dyslipidemia in Type 1 Diabetes
(2020-01-08)Background: Cardiovascular disease (CVD) is a major cause of shortened longevity in individuals with type 1 diabetes. Dyslipidemia is one of the important modifiable risk factors. Aims: To investigate different aspects ... -
Heart failure epidemiology with emphasis on young adults
(2019-11-20)Background: Heart failure (HF) is a major health problem worldwide with exponentially increasing incidence with age and the majority of patients being elderly. In recent years, an increase in hospitalization and prevalence ... -
Health-Related Quality of Life and Growth Hormone Treatment
(2019-11-18)Introduction Growth Hormone (GH) is used to increase height in Turner Syndrome (TS), the most common sex-chromosome aberration in women. GH is also beneficial for bone mass. However, little is known about how GH treatment ... -
Body mass index and mental health in young people - predictors of early heart failure and cardiomyopathy
(2019-11-18)Heart failure among young people is rare, but in contrast to decreasing incidence rates overall, recent studies have found increasing rates among the young over the last decades. Concomitantly, cardiomyopathies, which ... -
Cardiac lipids and their role in the diseased heart
(2019-11-13)Lipids play an essential role within the heart as they are involved in energy storage, membrane stability and signaling. Changes in cardiac lipid composition and utilization may thus have profound effects on cardiac ... -
Bedömning i samverkan - en väg till remission vid schizofreni
(2019-11-11)Background: The process from assessment of symptoms and function to various efforts in psychiatric outpa-tient care is still a "black box". Our knowledge of the connection between processes in care and the patient's status ... -
Factors influencing outcome in patients with obstructive hypertrophic cardiomyopathy - Effects of pharmacotherapy, pacing and surgical myectomy
(2019-11-07)Background: Most studies on risk factors for disease-related mortality in hypertrophic cardiomyopathy (HCM) have emanated from specialized tertiary centres which are subject to possible referral bias. About one quarter of ...