Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin: Recent submissions
Visas titlar 181-200 av 322
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Prognostic markers in pediatric leukemia and mechanisms of KRAS induced leukemogenesis
(2013-12-20)Leukemia results from uncontrolled growth of genetically altered blood cells. Depending on the cell type of origin, the leukemia is defined as T-cell, B-cell, or myeloid and as acute or chronic depending on its characteristics. ... -
Reversal of thyroid dedifferentiation and an invasive phenotype by small molecule kinase inhibitors: an experimental study on normal and malignant cells
(2013-11-29)Refractoriness to I-131 in dedifferentiated thyroid cancer is a great concern that restricts radioiodine therapy. There is also a lack of knowledge in understanding the mechanisms leading to repressed sodium iodide symporter ... -
Healing Cartilage - aspects on regenerative methods
(2013-11-27)Articular cartilage has poor intrinsic capacity to heal and defects can cause severe pain for the patient. If the healing process is not assisted the damage might deteriorate and lead to the onset of osteoarthritis. ... -
Epidemiologic studies on human enteric viruses in Cameroon
(2013-11-27)Enteric viruses are a diverse group of viruses that include those that multiply in the intestinal epithelium and cause gastroenteritis, and those that first multiply in the intestine and then spread to extra-intestinal ... -
On the assessment and impact of liver fibrosis in patients with chronic hepatitis C
(2013-11-22)Hepatitis C virus (HCV) infection is associated with increased risk of severe liver damage, cirrhosis, and hepatocellular carcinoma (HCC). Despite pending highly efficacious HCV treatment, assessment of liver damage will ... -
The role of IL-17A and IFNγ in vaccine-induced protection against Helicobacter pylori
(2013-11-22)It is estimated that half the world’s population is infected with Helicobacter pylori in the stomach. Chronic H. pylori infection can lead to peptic ulcer disease or gastric cancer, but only in a sub-population of infected ... -
Development of immunogenicity models in mice for improved risk assessment of biopharmaceuticals
(2013-11-11)The development of anti-drug-antibodies (ADA) to biopharmaceuticals, e.g. recombinant proteins including monoclonal antibodies (mAb) can lead to adverse events and clinical complications. These include reduced effect of ... -
Inhibition of HIV-1 and HSV-2 infection by glycosaminoglycan mimetics
(2013-10-08)HIV-1 is a sexually transmitted pandemic pathogen that causes progressive defects in cell-mediated immunity for which curative treatment and prophylaxis are lacking. In addition to CD4 and chemokine receptors of protein ... -
Candidate antivirals for treatment of respiratory syncytial virus and coronavirus infections: Identification and elucidation of mode of antiviral activity
(2013-09-27)Respiratory syncytial virus (RSV) and coronaviruses (CoVs) are frequent causes of respiratory disease in humans. RSV can cause severe bronchiolitis and pneumonia in infants, especially in those born prematurely or with ... -
Subsets of intestinal dendritic cells and their role in orally-induced immune responses
(2013-09-20)Vaccination is the most effective means of preventing infectious diseases and improving global health. However, few vaccines have successfully been developed for protection at mucosal surfaces where most infectious pathogens ... -
Studies on therapeutic vaccination and immune evasion in chronic lymphocytic leukemia
(2013-09-10)Chronic lymphocytic leukemia (CLL) is characterized by an accumulation of malignant B cells in blood, bone marrow and secondary lymphoid organs and is considered incurable. Our main aims were to investigate different aspects ... -
A study of the contribution of mast cells to vaccination - Regulatory functions of Fc gamma receptors
(2013-08-23)This thesis aimed to explore the regulatory roles of mast cells in vaccination. Mast cells have been increasingly recognized as important orchestrators of immune regulation in both health and disease, in addition to their ... -
Varicella-zoster virus infections of the central nervous system
(2013-05-24)Both varicella (chickenpox), and the reactivated form of herpes zoster (shingles), may cause neurological complications with various central nervous system (CNS) manifestations. Following introduction of PCR as a diagnostic ... -
The protective role of Nrf2/Keap1 in neurological disease and oxidative stress-induced cell damage
(2013-05-22)Oxidative stress is a common feature in the pathogenesis of many diseases, including neurodegenerative diseases like Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS). Nrf2 and Keap1 regulate an inducible ... -
Epidemiology, molecular characterisation and toxin regulation of enterotoxigenic Escherichia coli (ETEC) isolated from children with diarrhoea
(2013-05-22)Acute diarrhoeal diseases are among the major causes of morbidity and mortality in children under 5 years of age in developing countries. Knowledge of the epidemiology of such diseases and the causative agents is important ... -
Activation and immunoregulatory function of type II natural killer T lymphocytes
(2013-05-02)Natural killer T (NKT) lymphocytes make up a potent immunomodulatory subset of innate-like lymphocytes. NKT cells are activated by self-lipids presented by the unconventional MHC class I-like molecule CD1d, resulting in ... -
Expression profiling of Gastrointestinal Stromal Tumors - Biomarkers for Prognosis and Therapy
(2013-04-17)Gastrointestinal stromal tumor (GIST) is a mesenchymal tumor of the gastrointestinal tract with a clinical spectrum ranging from indolent tumors to tumors with aggressive behavior and poor patient survival. The established ... -
The role of dendritic cells in adjuvant-induced immune responses
(2013-03-07)Dendritic cells (DCs) are sentinels of mucosal surfaces, residing directly under the epithelial layer. DCs are among the first cells that come in contact with pathogens and have the unique ability to activate T cells that ... -
Genetic studies of children with mental retardation
(2013-02-20)Mental retardation (MR) is characterised by significant limitations in intellectual function and adaptive behaviour. It is estimated that MR affects up to 3% of the population in Europe. Patients with MR are an aetiologically ... -
Recruitment of regulatory and conventional T cells to colon adenocarcinomas
(2013-02-08)Colorectal cancer is one of the most common malignant diseases, with an annual incidence of over one million cases worldwide. Although survival depends strongly on tumor stage at diagnosis, lymphocyte infiltration has been ...