Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin: Recent submissions
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The breast cancer microenvironment and cancer cell secretion - specific effects on cancer progression and subtypes of cancer cells
(2021-01-22)Breast cancer is the cancer form responsible for the most cancer-related deaths among women worldwide, and novel targeted therapies are highly needed. The tumor microenvironment consists of several components, including ... -
Regulation of Human Mitochondrial DNA Replication and Transcription
(2021-01-18)Regulation of Human Mitochondrial DNA Replication and Transcription Majda Mehmedović Department of Medical Biochemistry and Cell biology, Institute of Biomedicine Sahlgrenska Academy, University of Gothenburg Gothenburg, ... -
Tick-borne encephalitis - clinical and virological aspects
(2021-01-05)Tick-borne encephalitis (TBE), an important central nervous system infection in Europe and Asia, is caused by the TBE virus (TBEV), which is mainly transmitted to humans through tick bites. This thesis studied data from ... -
Mass spectrometric analyses of proteoglycans - Novel tools for studying prohormones in insulin-producing cells
(2020-12-15)Proteoglycans (PGs) are proteins that carry one or more negatively charged glycosaminoglycan (GAG) chains. Proteoglycans have been identified in essentially all multicellular organisms, and are implicated in a wide range ... -
Anaplastic lymphoma kinase activity, a therapeutic target, suppresses neuroblastoma cell differentiation
(2020-11-27)Neuroblastoma (NB) is the most common extracranial pediatric solid malignancy caused by the failed differentiation of precursor cells of the developing sympathetic nervous system. NB accounts for about 15% of childhood ... -
Transcriptomic and functional studies of fusion oncogene-driven salivary gland tumors
(2020-11-25)Fusion genes are potent oncogenic drivers resulting from exchange of regulatory/coding sequences between two genes. They were originally identified in leukemias but are now recognized as key oncogenic events also in many ... -
Exploring novel therapeutic strategies in neuroblastoma
(2020-10-29)Neuroblastoma (NB) is the most frequently diagnosed extracranial tumour in children, which arises from transient embryonal tissue of the neural crest that fails to complete terminal differentiation into neurons. Even after ... -
Chromatin and transcriptome-based integrative approaches to profile functional long noncoding RNAs - A computational approach
(2020-10-07)One of the major hallmarks of cancer is aberrant or uncontrollable cell division, which occurs due to a defective cell cycle process. During the synthesis phase (S-phase) of the cell cycle, before cell division or mitosis ... -
Acute respiratory infections among children in the Democratic Republic of Congo - nasopharyngeal pathogens, antibiotic resistance and vaccination
(2020-09-29)ABSTRACT Acute Lower Respiratory Infections (ALRI) remain a leading cause of morbidity and mortality among children in the Democratic Republic of the Congo (DR Congo). The pneumococcal conjugate vaccine PCV13 was ... -
Recombinant mucin-type proteins as tools for studies on the interactions between Helicobacter pylori and its carbohydrate receptors
(2020-06-11)Glycan-protein interactions are important in pathogen adhesion and infections. H. pylori has adhesins which enables it to bind to glycans on the gastric mucosa and, in the long run, cause gastric cancer. The reported current ... -
Aspects of infection and leukemia in Rwanda
(2020-05-19)A first part of this thesis addressed the potential impact of variants of genes encoding interferon-λ4, which is a cytokine that participates in protection against pathogens at epithelial surfaces, for the resolution of ... -
Epidemiology of viral respiratory infections with focus on in-hospital influenza transmission
(2020-05-18)Human Rhinoviruses (HRV) and influenza viruses are respiratory pathogens which represent a major global disease burden. Healthcare-associated infections (HCAI) are increasingly recognized as a public health concern, but ... -
Identification of novel antibiotic resistance genes through the exploration of mobile genetic elements
(2020-05-12)Backgrounds and aims: The evolution of multi-resistant pathogens is seriously threatening our ability to provide modern healthcare. Many of the mobile resistance factors in clinics appear to originate from environmental ... -
Recurrent infection with Extended-Spectrum Beta-Lactamase (ESBL) -producing Enterobacteriaceae
(2020-05-05)Infections with Extended-Spectrum Beta-Lactamase (ESBL)-producing Enterobacteriaceae (EPE) are increasing globally. The most common EPE are the gut pathogens Escherichia coli (ESBL-E. coli) and Klebsiella pneumoniae (ESBL-K. ... -
Release and Clearance Mechanisms of Cardiac Troponin
(2020-04-28)Myocardial infarction (MI) is often suspected when a patient presents with chest pain. MI is defined as cardiac necrosis due to ischemia, most often mediated through impaired coronary perfusion. Cardiac necrosis results ... -
Impact of Genetic Variants in Inosine Triphosphate Pyrophosphatase and Interferon-λ4 on Natural History, Treatment Response and Ribavirin Pharmacology in Hepatitis C Virus Infection
(2020-04-23)Hepatitis C virus (HCV) impacts on global health with around 70 million chronically infected worldwide. The infection increases the risk of cirrhosis and primary liver cancer. The treatment until 2013 has been based on ... -
On the epidemiology, clinical presentation and transmission of respiratory viral infections
(2020-03-05)Respiratory viral infections encompass a large heterogenous group of pathogens that constitute a major burden of disease globally. The various routes of transmission including airborne spread make them difficult to control. ... -
Tumor cell heterogeneity profiling using single-cell analysis
(2020-02-13)Cancer is a diverse disease with large variations between tumor types and patients regarding tumor progression and prognosis. Additionally, most individual tumors are heterogeneous, containing subpopulations of cells with ... -
On the role of genetic variation and epigenetics in hemostatic gene regulation
(2020-01-17)Many genetic variants have been identified to associate with circulating levels of hemostatic proteins and with thrombotic or hemorrhagic disorders. However, the underlying molecular mechanisms remain largely unknown. ... -
Perspectives on urban wastewater as a source of microbial pollution
(2020-01-17)Wastewater treatment plants are important links for dissemination of intestinal bacteria into surface waters. In this study, twelve mallards were exposed to treated wastewater for a period of 55 days. Faecal samples were ...