Doctoral Theses / Doktorsavhandlingar Institutionen för medicin: Recent submissions
Now showing items 201-220 of 570
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Estrogens and interleukin-17 in arthritis and associated osteoporosis
(2016-11-15)Rheumatoid arthritis (RA), a disease characterized by persistent joint inflammation and joint destruction, is frequently associated with generalized osteoporosis. A female preponderance (3:1) is present in RA, and ... -
Dyspnea, with a focus on cardiovascular diseases: A primary health care perspective
(2016-11-11)Aim: The overall objective of our thesis is to describe, identify, and quantify the essential aspects of dyspnea both as a stand-alone symptom and as a symptom in patients with a special focus on cardiovascular diseases ... -
A gender perspective on irritable bowel syndrome: symptoms, experiences and the development of a person-centred support intervention
(2016-11-10)Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder which affects approximately ten percent of the world’s population and which is more prevalent among women than men. The hallmark symptoms of ... -
Gastrointestinal Symtoms and Fatigue in Patients with Quiescent Ulcerative Colitis
(2016-11-10)Gastrointestinal symptoms compatible with Irritable Bowel Syndrome (IBS) and fatigue are common in patients with quiescent ulcerative colitis (UC). The causes of these symptoms remain to be clarified. The overall aim of ... -
From efficacy to effectiveness: Two randomized controlled trials of lifestyle intervention postpartum
(2016-11-07)The overall aim of this thesis was to evaluate if, and how, weight loss can be achieved in women with overweight and obesity after pregnancy by combining results from two randomized controlled trials; LEVA and LEVA in Real ... -
The Role of Insulin and Insulin-like Ischemic Stroke and Cognitive Impairment
(2016-11-02)Background and aims: Insulin, insulin-like growth factor-I (IGF-I), and the six high-affinity IGF-binding proteins (IGFBPs) play an important role in growth, metabolism and regeneration throughout the entire life span. In ... -
Heart failure in the elderly: clinical phenotype, prognosis and influencing factors
(2016-11-01)Background: Heart failure has high morbidity and mortality and the incidence increases with age. Most randomized studies in heart failure were conducted in younger heart failure patients, despite the fact that the majority ... -
Potential biomarkers for acute and chronic rejection after lung transplantation
(2016-10-26)Abstract Chronic rejection in the form of bronchiolitis obliterans syndrome (BOS) is the main hindrance for long-term survival after lung transplantation. Repeated acute rejections (AR) constitute a major risk factor for ... -
Antimicrobial peptides in the treatment of infectious and inflammatory conditions - Preclinical studies of mechanism of action, efficacy, and safety
(2016-10-20)The rapid emergence of antibiotic-resistant microbes worldwide and the urgent need of new antimicrobial agents have stimulated interest in antimicrobial peptides (AMPs) as new therapeutics for treatment of infectious ... -
Work ability in young adults
(2016-09-29)Young adults may need special attention in their shift from student life to working life, to guarantee work ability. Being new at the workplace, they may encounter high expectations, resulting in high job demands. Also, ... -
Infectious immunity and pneumococcal vaccine responses in multiple myeloma and related disorders
(2016-09-15)Multiple myeloma (MM), Waldenstrom’s macroglobulinemia (WM), and monoclonal gammopathy of undetermined significance (MGUS) are B cell conditions associated with suppressed immune functions and susceptibility to infection. ... -
Platelet Inhibition and Bleeding Complications in Cardiac Surgery Patients - Clinical and experimental studies
(2016-09-02)BACKGROUND AND OBJECTIVE Dual antiplatelet therapy (DAPT) with acetylsalicylic acid and a P2Y12 inhibitor (clopidogrel, ticagrelor, or prasugrel) reduces thrombotic events in patients with acute coronary syndrome (ACS), ... -
Aspects of Plasminiogen Activator Inhibitor 1 in Metabolic Syndrome
(2016-05-31)Plasminogen activator inhibitor 1 (PAI-1) is the main inhibitor of the fibrinolytic system and binds irreversibly to tissue-type plasminogen activator (t-PA), and thereby inhibits the protective action of t-PA against ... -
Physical activity and well-being among adolescents: A public health perspective
(2016-05-26)Background: Physical activity among adolescents is diminishing and worldwide about 80% of 13–15-year-old adolescents do not meet the public health guidelines of minimum 60 minutes of daily physical activity of at least ... -
Insulin resistance and cardiovascular function - Observational, translational and interventional studies
(2016-05-26)Background: Microvascular disease is now recognized as an important driver for cardiovascular mortality and morbidity. Diabetic patients are known to suffer from this condition, leading to e.g. coronary ischemia as well ... -
Protein kinase STK25 is a regulator of hepatic lipid partitioning and whole body metabolism
(2016-05-24)In past decade, type 2 diabetes (T2D) and associated metabolic complications have become a major global threat for human health with epidemic increase in incidence. Currently available treatments for T2D have several ... -
Microbial regulation of Insulin-like peptide 5 and its implication on metabolism and bariatric surgery
(2016-05-23)The microbial community in our gastrointestinal tract, the gut microbiota, has great impact on our physiology. Particularly, the role for gut microbiota in host health and disease has been associated with modulation of gut ... -
Extracellular Vesicles and RNA interference in tumors
(2016-05-18)Extracellular vesicles (EVs) including apoptotic bodies (ABs), microvesicles (MVs), exosomes (EXOs) and cell derived artificial nanovesicles (NVs) are important mediators of cell-to-cell communication, in part by transferring ... -
Epigenetic regulation of gene expression in the vascular endothelium
(2016-05-12)Epigenetic mechanisms, such as DNA methylation and histone modifications, constitute one way for a cell or an organism to respond to changes in the surrounding environment. While histone modifications are recognized to ... -
Graft-versus-Host Disease: Eosinophils, Chimerism and Clinical Features in Patients Undergoing Allogeneic Hematopoietic Stem Cell or Multivisceral Transplantation
(2016-05-12)Abstract Graft-versus-host disease (GVHD) is a potentially severe complication that may develop after allogeneic hematopoietic stem cell transplantation (HSCT). It can also occur after transplantation with isolated ...