Doctoral Theses / Doktorsavhandlingar Institutionen för medicin: Recent submissions
Now showing items 181-200 of 570
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Longitudinal Vitamin D Status During Pregnancy in a Swedish Cohort: The GraviD Study
(2017-04-20)The aim of this thesis was to study vitamin D status among pregnant women in Sweden and if it was associated with gestational complications. A total of 2125 women were recruited at registration for antenatal care. Data ... -
Cortical porosity - Its regulation and association with fracture
(2017-04-11)Objective: Osteoporosis is a disease characterized by low bone mineral density and deteriorated bone microstructure. This thesis aimed to determine whether cortical porosity is associated with previous fracture and ... -
Emerging viruses in organ transplant recipients - immune responses to H1N1/09 influenza vaccine and Hepatitis E virus infection
(2017-03-16)Solid organ transplant (SOT) recipients run the risk of serious infections. The pandemic influenza A H1N1/09 had unknown severity, so large-scale vaccination was needed. The AS03-adjuvanted vaccine (Pandemrix) had unknown ... -
Childhood overweight and obesity in preschool children - an emerging problem in urban and rural Vietnam. A study of epidemiology and associated factors.
(2017-03-10)Background: Childhood overweight and obesity is considered a global epidemic. From being a health problem mainly in high-income countries, it is now an emerging problem in low- and middle-income parts of the world as well. ... -
Cardiac surgery and antiplatelet therapy
(2017-03-08)Background Dual antiplatelet therapy (DAPT) with acetylsalicylic acid (ASA) and a P2Y12 inhibitor improves outcome in acute coronary syndrome (ACS). In the subset of ACS patients undergoing urgent cardiac surgery, ongoing ... -
On the role of gut microbiota in intestinal physiology and hepatic metabolism
(2017-03-03)The gut microbiota, a complex and dynamic community of microbes in the mammalian gut, has coevolved with us for ample time providing mutual benefits. However, mechanistic knowledge of these has been limited, but are now ... -
Aspects of management of depression in primary care
(2017-03-03)Aim: The general aim of this thesis was to evaluate effects of recurrent use of a self-assessment instrument in general practitioner (GP) consultations with the patient with depression in the primary care clinical context. ... -
Well-being, Body Perception and Weight Status in Young Swedes - The Grow Up Studies
(2017-02-24)The overall aim of this thesis was to investigate well-being, body perception and weight status in an adolescent Swedish population growing up in a changing society with increasing obesity prevalence. The major aims were ... -
Ostructive lung disease - occupational exposures, smoking and airway inflammation
(2017-02-06)Abstract Obstructive lung disease is a group of respiratory diseases characterized by airways obstruction. Among them the more frequent are asthma and chronic obstructive pulmonary disease (COPD). Obstructive lung ... -
Adaptive immune maturation in relation to allergic disease and vaccine responses in children
(2017-01-30)Adaptive immune maturation in children is likely the result of a complex interplay between both intrinsic and environmental factors, but surprisingly little is known about how early life immune maturation is related to ... -
Functional Modulation of the Pattern Recognition Formyl Peptide Receptors in Neutrophils - Lipopeptides - allosteric modulators of G-protein coupled receptors
(2017-01-20)G-protein-coupled receptors (GPCRs), which are the largest class of cell-surface receptors, are involved in a range of physiologic processes and pathologies, making this a highly interesting group of proteins as targets ... -
Clinical hypertension - from early prediction to prevalence, treatment adherence and outcome of resistant hypertension
(2017-01-19)Aims The four studies in this thesis highlight both undetected hypertension and hypertension in patients receiving extensive blood pressure treatment. The aim of the fi rst study was to investigate whether, and by which ... -
The pro-atherogenic role of Intimal hyperplasia
(2016-12-22)Atherosclerosis is a leading cause of mortality worldwide, and results from accumulation of plasma lipoproteins, mainly low-density lipopro-teins (LDL), in the sub-endothelial layer of the arterial wall. In this the-sis, ... -
COPD: Incidence, prognosis and co-morbidity with special focus on heart disease
(2016-12-20)The aim of the thesis was to contribute to the knowledge on chronic obstructive pulmonary disease (COPD) with respect to incidence, risk factors, prognosis and comorbidities. With the epidemiological approach, samples from ... -
Effects of growth hormone in the hippocampus and cortex of adult rodents
(2016-12-07)Background and Aims: Growth hormone (GH) affects proliferation, regeneration and specific plasticity in the adult brain. We aimed to investigate new mechanisms of local and circulating GH in the brain, and to explore the ... -
Carbonic anhydrase activity in sleep apnea - a potential therapeutic mechanism for intervention
(2016-11-30)There is no pharmacological treatment for obstructive sleep apnea (OSA) in clinical practice. The overall aim of this thesis was to investigate the effect of carbonic anhydrase (CA) enzyme activity on sleep apnea severity ... -
Axial spondyloarthritis - with special emphasis on prevalence, perceived health and predictors
(2016-11-18)The objectives of this thesis were to assess the validity of the diagnostic codes for ankylosing spondylitis and undifferentiated spondyloarthritis in the national patient register (study I), and to estimate the prevalence ... -
Risk factors of type 2 diabetes and excess risk of stroke in patients with diabetes
(2016-11-17)The incidence of type 2 diabetes is increasing worldwide, mainly because of increasing life expectancy and changes in lifestyle. However, several other factors may also increase the risk of type 2 diabetes and their ... -
Non-invasive assessement of coronary flow velocity: Clinical and experimental studies
(2016-11-17)BACKGROUND AND OBJECTIVES Coronary flow velocity (CFV) and coronary flow velocity reserve (CFVR) evaluated by transthoracic ultrasound is a promising method to assess ischemic heart disease. CFVR is the ratio between ... -
Exhaled particles for monitoring of airway inflammation
(2016-11-17)Non-invasive collection methods suitable for studying the composition of the respiratory tract lining fluid (RTLF) in small airways are currently not readily available. The overall aim of this thesis was to contribute to ...