Doctoral Theses / Doktorsavhandlingar Institutionen för medicin: Recent submissions
Now showing items 241-260 of 570
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Studies on microcirculation in insulin resistance
(2015-11-26)The overall aim of this thesis was to investigate the microcirculation in insulin resistance, with focus on the expression of endothelin-1, through a translational approach. Specific aims: 1) Investigate if circulating ... -
Cadmium, kidney and bone
(2015-11-11)Toxic heavy metals, such as cadmium, mercury and lead, occur in the environment both naturally and as contaminants due to agricultural and industrial activities. The aims of this thesis were to examine the levels of these ... -
Obesity - surgical treatment and molecular mechanisms
(2015-11-11)Obesity is a condition of high prevalence and is associated with increased morbidity and mortality. Bariatric surgery is an effective treatment of obesity and reduces the risk for morbidity and mortality, but little is ... -
Aspects of validity in stress research
(2015-11-05)Aim: To increase knowledge about validity evaluation and interpretability of a multi-item self-report questionnaire used in occupational health and stress research, and to investigate longitudinal associations between the ... -
Obstructive Sleep Apnea in Cardiovascular Disease - Mechanisms and Impact of Treatment
(2015-10-29)ABSTRACT Background: Scientific understanding of obstructive sleep apnea (OSA) has increased exponentially during recent decades, suggesting a link between OSA and cardiovascular disease. Few randomized controlled trials ... -
Studies on carotid plaque vulnerability using contrast enhanced ultrasound
(2015-10-14)ABSTRACT Background and Aim: Contrast-enhanced ultrasound is a method to examine neovessels that may be present inside the atherosclerotic plaque of the carotid arteries. These neovessels are believed to be involved in ... -
Intimate partner violence and its mental health and help seeking implications for young adults in Rwanda
(2015-10-13)Aim: This thesis aimed to explore the magnitude of Intimate Partner Violence (IPV), its risk factors and resulting mental health effects. A further aim was to explore the barriers to care for people suffering from mental ... -
Integrative network modeling of large multidimensional cancer datasets
(2015-10-07)Our ability to conduct detailed molecular investigations on tissue samples have, during the past decade, enabled the formation of databases containing measurements from thousands of cancer tumors. To harness the potential ... -
Immune escape in chronic leukemia
(2015-10-02)Reactive oxygen species (ROS) are produced by myeloid cells as a mechanism of defense against infection, but also to resolve inflammation, as ROS can induce cell death in T cells and NK cells. ROS production may also be ... -
Vitamin D status and skeletal changes during reproduction- A longitudinal study from late pregnancy through lactation
(2015-09-25)Low vitamin D status has been associated with sub-optimal bone health. During both pregnancy and postpartum, it has been speculated that vitamin D status may affect maternal bone health, due to its importance in maintaining ... -
Podocyte Melanocortin 1 Receptor Mediated Signaling
(2015-09-10)Treatment of patients with nephrotic syndrome (NS) is currently unspecific and directed at ameliorating the symptoms rather than eliminating the cause. NS is actually a multitude of glomerular diseases characterized by ... -
Effects of microbial metabolites on host physiology
(2015-08-24)In recent years it has become increasingly clear that the gut microbial community, the microbiota, has a vast impact on obesity, insulin signaling and glucose homeostasis. More specifically, there are microbiota-derived ... -
Characterization of chronic aortic and mitral regurgitation using echocardiography and cardiovascular magnetic resonance
(2015-08-24)Introduction – Grading of chronic aortic (AR) and mitral regurgitation (MR) severity can be obtained by echocardiography and cardiovascular magnetic resonance (CMR). The aims of the four studies were: (1) to establish ... -
Fatigue in persons with rheumatoid arthritis: A person-centred physical therapy approach
(2015-08-21)Fatigue is a prominent symptom in persons with rheumatoid arthritis (RA) with great impact on daily life. Despite the improvement in pharmacological treatment of RA over the last decades, a large number of persons with RA ... -
Socioekonomiska aspekter av diabetes och kardiovaskulär sjukdom
(2015-06-04)Four hundred million people in the world have diabetes. The incidence of type 1 diabetes has increased steadily in the last few decades and it is now the second most common chronic disease of childhood. Type 2 diabetes ... -
Intracellular radicals in neutrophils - processing and functional implications
(2015-05-21)Neutrophils are the most abundant leukocyte in human blood and essential components of our defense against microbial pathogens. These cells can neutralize microbial pathogens by phagocytosis, which involves engulfment and ... -
Cardiac lipid storage and metabolism following myocardial ischemia
(2015-05-21)Myocardial ischemia is associated with cellular- and metabolic adjustments within the heart, including accumulation of lipids. Myocardial lipids are stored in cytosolic droplets, consisting of a core of neutral lipids ... -
Acute coronary syndrome and cardiac arrest in the elderly
(2015-05-11)The elderly are currently the fastest growing segment of clinical practice but the quality and quantity of the underlying scientific evidence to guide treatment is limited. In this thesis five different studies investigating ... -
Clinical Aspects of Bleeding and Transfusion in Cardiac Surgery
(2015-05-06)Abstract Excessive bleeding after cardiac surgery is a serious complication that is associated with increased morbidity and mortality. The bleeding is multifactorial and influenced by both surgical factors and impaired ... -
Prevalence, risk factors and comorbidities of COPD among never-smokers
(2015-04-30)The overall aim of this thesis was to investigate prevalence, risk factors and comorbidity of COPD among never-smokers. COPD was in this thesis defined as a syndrome also including prior asthma diagnosis with chronic airway ...