Doctoral Theses / Doktorsavhandlingar Institutionen för medicin: Recent submissions
Now showing items 401-420 of 570
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Regulation of vascular endothelial t-PA expression in inflammation: Potential target for pharmacological modulation
(2011-11-03)The endogenous fibrinolytic system is important for preventing occluding thrombosis and subsequent tissue infarction. The main activator of the fibrinolytic system in the vascular compartment is tissue-type plasminogen ... -
The role of S100A4 protein as a regulator of inflammation and bone metabolism in experimental arthritis
(2011-10-28)S100A4 belongs to the family of calcium-binding S100 proteins and modulates cell proliferation, cytoskeletal rearrangement, cell motility, and angiogenesis. Increased levels of S100A4 expression correlate with high ... -
Alcohol prevention in Swedish primary health care
(2011-10-11)Abstract Aims: The objectives of this thesis are to describe attitudes among general practitioners (GPs) and district nurses (DN) towards working with risk alcohol drinking and focus on the achievements of the Swedish ... -
Risk factors for fractures - a link between metabolic bone disease and cardiovascular disease
(2011-09-30)Introduction: Fractures and cardiovascular disease (CVD) are a burden to society, as they result in high morbidity and mortality in both men and women. Aim: The aim was to study prospectively modifiable risk factors for ... -
Population-based studies on acute leukemias - lessons from the Swedish Adult Acute Leukemia Registry
(2011-09-12)Acute leukemia (AL) is a rare, potentially curable, aggressive neoplasm of hematopoietic origin. AL is a heterogeneous disease and is further subdivided according to clinical and biological features. The aims were to ... -
Personality and adherence to medication treatment
(2011-09-01)Abstract: Striving for improved adherence to medication treatment is of vital concern, as low adherence is a major obstacle in treating many prevalent chronic diseases. Several factors have been identified that seem to ... -
Molecular mechanisms of the kidney in health and disease
(2011-05-27)In 2010, 307 Swedish patients received a new kidney through transplantation, and the first of April 2011, 603 patients were on the kidney transplant waiting list. In Sweden over 8000 patients are presently in active uremic ... -
Ultrasound assessment of carotid atherosclerosis focusing on plaque characteristics and changes over time
(2011-05-26)In a clinical perspective better methods to identify subjects at increased cardiovascular risk are needed. Atherosclerotic plaques of the carotid arteries with low echogenicity have been related to future clinical events. ... -
Psychosocial and stress-related aspects on ischemic heart disease
(2011-05-26)Objective: To study different aspects of ischemic heart disease (IHD) i.e. stress related risk factors, biochemical markers of stress, in particular the cortisol awakening response (CAR) and outcome in terms of health ... -
Renal hemodynamics in renal artery stenosis and angiotensin II-dependent hypertension. Pathophysiological and diagnostic aspects.
(2011-05-26)Patients with renovascular hypertension have a poor renal and cardiovascular prognosis. To improve the care of these patients, we need to increase knowledge about the pathophysiological mechanisms involved. Thus, the aims ... -
Studies on treatment of renal anemia in patients on chronic hemodialysis
(2011-05-23)In patients with chronic kidney disease, treatment with erythropoiesis-stimulating agents (ESA) effectively corrects anemia. Most of these patients also need supplementation with regular iron injections to secure iron ... -
Myofibroblasts and polyploid cells in the conjunctival surface after allogeneic hematopoietic stem cell transplantation
(2011-05-09)Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative treatment modality for hematological malignancies, such as leukemia and lymphoma. However, a major complication of the procedure is ... -
Loved ones within Palliative Care-understanding, strategies and need for support
(2011-04-15)It is well known that during the palliative process both patient and loved ones have to face, and prepare themselves, for the patient´s approaching death. Their daily life will be marked by the disease, and physical, social, ... -
Estimation of risk in the field of osteoporosis
(2011-04-15)Introduction: Osteoporosis has been recognised as an established and well-defined disease that affects more than 75 million people in the United States, Europe and Japan. Osteoporosis has been operationally defined by the ... -
Properties of the glomerular endothelial cell surface layer in vitro and in vivo.
(2011-03-25)A healthy kidney produces final urine that is practically devoid of proteins and other physiologically important solutes. Tremendous amounts of fluid are filtered every day through the glomerular filtration barrier which ... -
Analysis of Endogenous Particles in Exhaled Air
(2011-03-25)Exhaled air contains non-volatile particulate material from the respiratory tract. The precise location in which exhaled particles are formed is unknown, and details on their chemical content are scarce. The aim of this ... -
Low back pain and widespread pain in primary health care: Early access to physical therapy, treatment and prognostic factors
(2011-03-18)Abstract Low back pain (LBP) and widespread pain (WP) are common and incur considerable costs to society mainly due to work disability. Identification of prognostic factors, intervention and early access to care seems ... -
Longitudinal Common Carotid Artery Wall Motion - mechanistic, prognostic and translational studies
(2011-02-15)The longitudinal arterial movement of the common carotid artery (CCA) has been less investigated during the past compared to the radial movement. This is probably due to lack of an adequate measuring method. Velocity vector ... -
Women's alcohol and drug use. Risk indicators from everyday life
(2011-01-19)Aims: The overall aim of this thesis was to explore how various aspects of everyday life, measured using self-reported experiences from childhood, adolescence and adulthood were associated with alcohol and drug use in a ... -
Childhood obesity prevention in the context of socio-economic status and migration
(2011-01-04)Abstract Childhood obesity prevention in the context of socio-economic status and migration Maria Magnusson, Department of Public Health and Community, Institute of Medicine at Sahlgrenska Academy, University of ...