Doctoral Theses / Doktorsavhandlingar Institutionen för medicin: Recent submissions
Now showing items 381-400 of 570
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Glucocorticoids - outcome in patients with glucocorticoid deficiency and Cushing's syndrome
(2012-05-15)Glucocorticoids (GCs) are steroid hormones that have a major impact on human metabolism and are essential for life. Chronic GC overexposure, called Cushing’s syndrome, is characterized by central obesity, muscle atrophy, ... -
Defining the Role of GGTase-I in the Development of Rheumatoid Arthritis and Atherosclerosis
(2012-05-08)RHO family proteins control cell movement and intracellular signaling by cycling between active GTP-bound and inactive GDP-bound states. Aberrant signaling of RHO GTPases has been implicated in many diseases including ... -
Metabolic aspects of cardiac arrhythmias
(2012-05-07)Cardiac arrhythmias are an important cause of mortality and morbidity in patients with cardiac diseases. Sudden death due to ventricular tachycardia and fibrillation (VT/VF) in the setting of acute myocardial infarction ... -
Fibromyalgia and chronic widespread pain. Dimensions of fatigue and effects of physiotherapy.
(2012-04-17)Aims. Fatigue is a severe problem for patients with fibromyalgia (FM) and chronic widespread pain (CWP). The general aims of the thesis were to describe the fatigue experienced by patients with FM and CWP, explore the ... -
The role of B cells in rheumatoid arthritis
(2012-03-26)It has been known for a long time that B cells play a role in rheumatoid arthritis (RA). By production of autoantibodies, presentation of auto-antigens and by producing cytokines B cells may contribute to the pathogenesis ... -
Immunological and Genetic Markers Predicting Treatment Outcome in Hepatitits C Virus Infection
(2012-03-20)Hepatitis C is a blood-borne infection caused by the hepatitis C virus (HCV). A chronic infection, which develops in most infected subjects, may lead to liver cirrhosis with ensuing liver dysfunction and liver cancer. The ... -
Den kompetenta allmänläkaren - mottagningsrummets praxis utmanar idealbilden
(2012-03-13)The skilful general practitioner – ideals challenged by practice Background and aim: The world organization for general practitioners, Wonca, has formulated research based core competencies for general practice. However ... -
ICT use and mental health in young adults. Effects of computer and mobile phone use on stress, sleep disturbances, and symptoms of depression
(2012-03-01)The overall aim of this thesis was to explore possible associations between information and communication technology (ICT) use and mental health symptoms among young adults. By “ICT” in this context is meant mainly computer ... -
Aspects of Abnormal Glucose Regulation in Various Manifestations of Coronary Artery Disease
(2012-02-03)Background Diabetes is common among patients with coronary artery disease (CAD) and is associated with an approximate doubling of the mortality risk in this patient population. Prediabetes, an intermediate glycometabolic ... -
Differentiation factor Fms-like tyrosine kinase 3 ligand is a modulator of cell responses in autoimmune diseases
(2012-01-23)Fms-like tyrosine kinase 3 (Flt3) is a receptor on common stem cell progenitors and has a crucial role in hematopoesis, regulating cell proliferation and differentiation in man and mice. The growth factor Flt3 is activated ... -
Mechanisms for and consequences of cellular lipid accumulation - Role of the Very Low Density Lipoprotein (VLDL) receptor
(2011-12-02)Lipid accumulation in non adipose tissue is associated with various cases of tissue dysfunction and tissue failure. Reduced availability of oxygen is known to cause intracellular lipid accumulation in cardiomyocytes as ... -
On the causes of ventricular arrhythmia, its treatment and outcome
(2011-11-25)On the causes of ventricular arrhythmia, its treatment and outcome Christina Holmgren Institute of Medicine Sahlgrenska Academy at University of Gothenburg Göteborg, Sweden ABSTRACT Background: Ventricular arrhythmia ... -
Eosinophils, their progenitors and T helper cells in allergic airway inflammation
(2011-11-25)Introduction: Asthma is a heterogeneous chronic lung disease associated with pronounced inflammatory changes in the airways. Eosinophilic inflammation is the trait that is best linked to symptoms and treatment responses ... -
Cell death and clearance - studies of human neutrophils from blood and tissue
(2011-11-25)Neutrophils are phagocytic cells that typically migrate from circulation to tissues in order to combat microbial invasion. The journey from blood to tissue involves mobilization of intracellular organelles which results ... -
Diabetes and obesity in primary health care - a condition beyond physiological factors
(2011-11-18)Aims: The objectives of this thesis are to illustrate how obese and normal-weight individuals with type 2 diabetes (T2DM) experience their health status and health care interactions and to highlight the diabetes team ... -
Aspects on long-term treatment with tyrosine kinase inhibitors in Chronic myeloid leukemia
(2011-11-18)Chronic myeloid leukemia (CML) is caused by the tyrosine kinase activity of the oncoprotein BCR-ABL. The introduction of tyrosine kinase inhibitors (TKIs) targeting BCR-ABL has profoundly changed the prognosis of CML. ... -
Pharmacological interventions against myocardial ischemia and reperfusion injury
(2011-11-09)Background: Ischaemic heart disease is the leading cause of death in the industrialised world. Although the concept of early restoration of coronary blood-flow constitutes an important factor to reduce the injury caused ... -
Interleukin 15 and 17 in Staphylococcus aureus arthritis
(2011-11-09)Staphylococcus aureus–induced arthritis leads to severe joint destruction and high mortality despite antibiotic treatment. Thus, there is a need to identify new treatment targets in addition to antibiotic therapy. Interleukin ... -
Cardiac arrest outside and inside hospital from a 30 year perspective in the Municipality of Gothenburg
(2011-11-09)Aims: 1:To describe the epidemiology of both out-of-hospital cardiac arrest (OHCA) and in-hospital cardiac arrest (IHCA) in the Municipality of Gothenburg. 2:To describe the differences and similarities in cardiac ... -
Tobaksrökens effekter på den lymfocytrekryterande cytokinen interleukin-16
(2011-11-09)Background: There is an increased number of CD8+ cells in the airways in chronic obstructive pulmonary disease (COPD) and also an increased number of CD4+ cells in severe COPD. The CD4 cell chemoattractant interleukin ...