Doctoral Theses / Doktorsavhandlingar Institutionen för medicin: Recent submissions
Now showing items 521-540 of 570
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Plasminogen Activator Inhibitor 1 in Platelets - Studies of Synthesis, Activity, and Glycosylation Patterns
(2008-01-24)Plasminogen activator inhibitor 1 (PAI-1) is the main physiological inhibitor of tissue-type plasminogen activator. Thus PAI-1 plays an important role in decreasing the fibrinolytic activity in human blood. PAI-1 is present ... -
Ultrasound evaluation of atherosclerosis and other cardiovascular sources of cerebral embolism
(2008-01-18)The search for embolic sources has high priority in patients presenting with suspected cerebral embolism. Non-invasive cardiovascular ultrasound is frequently used to reveal the presence of carotid stenosis and cardiac ... -
Vascular Wall Responses to Bypass Grafting - Studies in Mice
(2008-01-18)Abstract Vein grafts are frequently used in bypass surgery for treatment of coronary artery disease and lower limb ischemia. Unfortunately the long-term patency is impaired by vein graft stenoses due to intimal hyperplasia ... -
Pathophysiological role and clinical relevance of cytokines in hypertensive heart failure. A combined clinical and experimental study
(2007-12-06)Although mortality due to heart failure has decreased significantly in the last decade since the introduction of ACE-inhibitors and β-adrenergic receptor blockers in the management of heart failure, chronic heart failure ... -
How can we optimize bystander basic life support in cardiac arrest?
(2007-11-23)The aim of this thesis was to describe various aspects of cardiopulmonary resuscitation (CPR) and CPR training in order to find approaches for enhancing bystander interventions. Cardiac care patients (n=401) were interviewed ... -
Effects of Biomechanical Stress on Gene Regulation in Vascular Cells
(2007-11-16)The vascular vessel wall is constantly exposed to biomechanical forces, such as shear and tensile stress. Biomechanical forces are important for several physiological and pathological processes and have been shown to ... -
Diagnosis of interatrial shunts and the influence of patent foramen ovale on oxygen desaturation in obstructive sleep apnea
(2007-11-06)Patent foramen ovale (PFO) is found in 27% of the population and although mostly asymptomatic, PFO has been associated with e.g. cryptogenic stroke and, rarely, also with oxygen desaturation. PFO and atrial septal defects ... -
Myocardial creatine metabolism in experimental infarction and heart failure
(2007-10-04)The failing heart is characterized by changes in structure, function and metabolism. All these changes are usually defined as pathologic remodelling. An important part of this negative remodelling process is disturbances ... -
Dilemmas and consequences of chronic disease-lived experiences of coeliac disease and neuropathic pain
(2007-09-27)Dilemmas and consequences of chronic disease-lived experiences of coeliac disease and neuropathic pain Akademisk avhandling som för avläggande av medicine doktorsexamen vid Sahlgrenska akademin vid Göteborgs Universitet ... -
Hip fracture prevention by screening and intervention of elderly women in Primary Health Care
(2007-09-18)Hip fracture prevention by screening and intervention of elderly women in Primary Health Care Daniel Albertsson Background – One in four Swedish women suffers a hip fracture (HF). In order to identify high-risk women we ... -
Fatty acids induce potentially atherogenic changes in extracellular matrix proteoglycans
(2007-09-10)Insulin resistance and type 2 diabetes (T2D) are associated with an increased prevalence of atherosclerotic cardiovascular disease (CVD). A key step in the initiation of atherogenesis is retention of low density lipoproteins ... -
Mechanism of F-actin crosslinking by filamin A and the anti-inflammatory functions of plasma gelsolin in bodily fluids
(2007-09-10)Gelsolin (GSN) and filamin A (FLNa) are two actin-binding proteins discovered in our laboratory over 30 years ago. GSN is a calcium-activated actin severing and barbed end capping protein that is expressed as both intracellular ... -
Growth Hormone in Athletes
(2007-08-24)Doping with growth hormone (GH) is a well-known problem both among elite athletes and among people training at gyms. It is mainly the anabolic and, to some extent, lipolytic effect of GH that is valued by its users. However, ... -
Health and Rehabilitation in a Psychosocial Context. A Ten Year Persepctive.
(2007-08-20)Abstract This thesis is a retrospective- and prospective study of 372 long-term sick listed individuals with diseases of the locomotor system that underwent vocational rehabilitation conducted by the Social ... -
Molecular Monitoring of Chronic Myeloid Leukemia Treated with Imatinib Mesylate
(2007-08-15)The BCR-ABL fusion gene product is a constitutively activated tyrosine kinase, which is fundamental in the pathogenesis of chronic myeloid leukemia (CML). Imatinib mesylate (imatinib, Glivec® or Gleevec®), a small molecule ... -
Molecular mechanisms in obesity-associated metabolic disease
(2007-07-12)Obesity is associated with increased morbidity and mortality. Subjects with obesity are at risk of developing several serious conditions such as type 2 diabetes, hypertension, coronary heart disease and stroke. This thesis ... -
Impairment of Endothelial Thromboprotective Function by Haemodynamic and Inflammatory Stress - Implications for hypertensive disease
(2007-06-29)The physiologically most important activator of intravascular fibrinolysis is tissue-type plasminogen activator (t-PA). The endothelium synthesizes and stores t-PA and regulated release of the enzyme is an important local ... -
Peripheral and central factors in the pathophysiology of irritable bowel syndrome
(2007-06-14)Irritable bowel syndrome (IBS) is a functional gastrointestinal (GI) disorder characterized by abdominal pain and/or discomfort together with abnormal bowel habits. The pathophysiology is complex and incompletely understood. ... -
Self-perceived Psychological Health and Vascular Changes in Childhood
(2007-06-08)Self-perceived Psychological Health and Vascular Changes in Childhood AKADEMISK AVHANDLING som för avläggande av medicine doktorsexamen vid Sahlgrenska akademin vid Göteborgs universitet kommer att offentligen ... -
The GH-IGF-1 Axis in Postmenopausal Women with Abdominal Obesity
(2007-06-01)Abdominal obesity is associated with blunted growth hormone (GH) secretion. GH treatment in abdominally obese men reduces visceral adipose tissue (VAT) and improves the metabolic profile. The aim of this study was to ...