Doctoral Theses / Doktorsavhandlingar Institutionen för medicin: Recent submissions
Now showing items 501-520 of 570
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BCG vaccination and the tuberculin skin test in a country with low prevalence of tuberculosis. Epidemiological and immunological studies in healthy subjects.
(2008-10-10)The immune response induced by vaccination with Bacille Calmette-Guérin (BCG) is not fully understood, and the interpretation of the tuberculin skin test (TST) is still under debate. This thesis was based on questions ... -
T cell Function in Patients with Dilated Cardiomyopathy
(2008-10-02)Dilated cardiomyopathy (DCM) is a heart muscle disease characterized by dilatation of one or both ventricles together with decreased systolic function. Its etiology is still largely unknown. However, immunological alterations ... -
Airway sensory hyperreactivity linked to capsaicin sensitivity. Definitions and epidemiology.
(2008-08-28)Aims: • To study the relationship between odour intolerance and capsaicin sensitivity and to develop a definition of airway sensory hyperreactivity (SHR). • To study epidemiology of odour intolerance; particularly ... -
Identification and imaging of lipids in tissues using TOF-SIMS
(2008-08-19)Introduction: Normal lipid metabolism in the adipose tissue, skeletal muscle and aortic wall is important for the physiological function of these tissues. Dyslipidemia that is often associated with intake of high energy ... -
Proton pump inhibitors: indications and acid rebound
(2008-07-04)Proton pump inhibitors (PPIs) are nowadays the therapy of choice in the management of a variety of upper gastrointestinal (GI) conditions particularly gastroesophageal reflux disease (GERD). Previous studies indicate that ... -
Open heart surgery and its consequences for well-being - the perspectives of patients, relatives and health care professionals
(2008-05-23)Introduction: Adjustment to open heart surgery (OHS) is complex and necessitates multidimensional explanations. The surgery does not always provide the desired outcome, which can contribute to reduced well-being among ... -
Cardiovascular and metabolic control in obese children and adolescents
(2008-05-23)Childhood obesity is an emerging risk factor for disease and mortality worldwide. The cardiovascular consequences and prevention thereof need to be further investigated. Exercise and weight loss are well examined and ... -
General Beliefs about Medicines among Pharmacy Clients, Healthcare Students and Professionals - Group Differences and Association with Adherence
(2008-05-23)Background: only about 50% of all medicines are used as the prescriber intended. If medicines are prescribed in an adequate way, an optimised adherence can decrease mortality and hospitalisation and improve health-related ... -
Iron absorption in man - diet modification and fortification
(2008-05-23)Background: Iron (Fe) deficiency is globally the most common form of nutrient deficiency. The approach to combat this problem can be divided into two major strategies a): increasing the dietary Fe bioavailability by diet ... -
Liver cirrhosis-epidemiological and Clinical Aspects
(2008-05-19)Liver cirrhosis is the end-stage of many different chronic liver diseases. Limited data exists on the epidemiology, natural history and complications of liver cirrhosis such as esophageal varices and malignancies in the ... -
Blood Pressure Elevation - Impact on Cardiovascular Structure and Endogenous Fibrinolysis
(2008-05-16)Blood pressure elevation is a major risk factor for cardiovascular events and the risk increases in a dose-dependant manner. It is of importance to identify subjects prone to develop hypertension and adverse cardiovascular ... -
Proliferative and protective effects of the GH/IGF-I axis on cardiomyocytes and neural progenitor cells
(2008-05-15)Cardiovascular disease is the most common cause of mortality in the Western world and the majority of cardiovascular deaths are caused by coronary artery disease or cerebrovascular disease. Growth hormone (GH) is a ... -
THE WINDING ROAD TO WOMANHOOD. Adolescents´ attitudes towards menstruation, womanhood and sexual health - observational and interventional studies
(2008-05-15)Menarche is a unique marker of female maturation representing the transition from childhood to womanhood. When entering adolescence, children face a number of challenges in areas such as the parent-adolescent relationship, ... -
The expression and function of CD25 B cells in man and in mice
(2008-05-15)B cells play an important role both in the physiology and pathology of immune responses by production of antibodies, cytokines and by presentation of antigens. It has been shown that human CD25 expressing B cells display ... -
Exosomal Shuttle RNA
(2008-04-04)Exosomes are small membrane nanovesicles of endocytic origin that can be released by many different cells to the extracellular environment. Exosomes have been found in a number of body fluids such as blood plasma, breast ... -
Assembly and Secretion of Atherogenic Lipoproteins
(2008-03-18)The classical dyslipidemia seen in patients with type 2 diabetes is characterized by elevated serum triglycerides (TG), low levels of high-density lipoprotein cholesterol and the appearance of small, dense low-density ... -
Bile Acid Induced Diarrhoea Pathophysiological and Clinical Aspects
(2008-03-18)A common cause for referral to gastroenterologists is chronic watery diarrhoea. Approximately 40% of these patients have idiopathic bile acid malabsorption (BAM) – a condition with unknown aetiology. The 75SeHCAT test, ... -
Microarray analysis of gene expression in human adipocytes and adipose tissue
(2008-02-21)Obesity has reached epidemic proportions worldwide and is associated with several serious conditions such as insulin resistance, type 2 diabetes, hyperlipidemia and atherosclerosis. Adipose tissue exerts important endocrine ... -
Myocardial metabolism in experimental infarction and heart failure
(2008-02-15)Abstract The heart is an organ heavily dependent on exogenous lipids for the oxidative production of adenosine-triphosphate (ATP) and therefore maintenance of normal cellular energy homeostasis. However, high energy ... -
Estrogen and raloxifene in experimental arthritis and osteoporosis
(2008-02-14)ABSTRACT In postmenopausal rheumatoid arthritis (RA), both the estrogen deficiency and the inflammatory disease contribute to the development of generalized osteoporosis. This leads to an increased risk of fracture, with ...