Doctoral Theses / Doktorsavhandlingar Institutionen för medicin: Recent submissions
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The population burden of gout and urate in Western Sweden
(2021-11-02)Background: Gout is the most common type of inflammatory arthritis and is associated with several comorbidities and an increased risk of cardiovascular disease (CVD). However, data on the epidemiology and comorbidity ... -
Mechanisms underlying inflammation, symptoms and quality of life in ulcerative colitis
(2021-10-06)A substantial proportion of patients with ulcerative colitis (UC) in remission demonstrate gastrointestinal (GI) symptoms, despite the absence of ongoing inflammation in the colon. The underlying mechanisms of these symptoms ... -
Adaptation of ventricular repolarization to heart rate change in humans
(2021-10-01)Background: Life-threatening cardiac rhythm disturbances and sudden death are common manifestations of heart disease. Disturbances in electrical recovery (ventricular repolarization; VR) are important mechanisms behind ... -
Predictors of survival in cardiac arrest
(2021-10-01)Cardiac arrest (CA) refers to the cessation of cardiac function. Survival is around 30% for in-hospital cardiac arrest (IHCA), and 10% for out-of-hospital cardiac arrest (OHCA). Many factors influence survival, ranging ... -
Cardiovascular morbidity and metabolic signature in patients with rheumatoid arthritis
(2021-09-09)Background and objectives: Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease with excess risk for cardiovascular morbidity and mortality. The treatment of RA by anti-inflammatory drugs has dramatically ... -
Cancer in organ transplant recipients
(2021-08-27)Tens of thousands of transplantations are performed around the world each year. Organ transplant recipients (OTR) are obliged to receive life-long medical treatment with immunosuppressive drugs to ensure graft function. ... -
T cells and chemokines in rheumatoid arthritis
(2021-08-18)In this thesis, we investigated if circulating proportions of specific CD4+ T cell subsets and blood chemokine levels were associated with disease activity and/or could predict remission in patients with early ... -
Intestinal transplantation: Outcome, complications and diagnostic approach
(2021-05-27)Background: Intestinal transplantation is a potentially lifesaving procedure conducted in candidates with e.g. intestinal failure. However, a limiting factor has been the complications, which are inherent to the procedure, ... -
Effects of an intervention and an organisational implementation for identification and treatment of common mental disorders in primary healthcare
(2021-05-26)Aim: This thesis aimed to evaluate the effects of one intervention and one organisational implementation for identification and treatment of common mental disorders (CMDs) in the primary healthcare in Region Västra Götaland, ... -
Lipoproteins in the postprandial state: Studies on the metabolism of triglyceride-rich lipoproteins using multicompartmental models
(2021-05-21)Lipoproteins are lipid-containing spherical particles that circulate in the human blood stream. The reason for their intense study over the decades is their ability to cause atherosclerosis1. Atherosclerotic cardiovascular ... -
Clinical aspects of Arteriovenous fistula use in a haemodialysis population. Results based on retrospective and internventional studies.
(2021-05-19)When a patient suffers from end stage renal disease, the vascular access becomes the lifeline to perform regular haemodialysis (HD) treatment. The recommended first choice is the surgically created native Arteriovenous ... -
The Force of Blood
(2021-05-12)Aim: The overarching aim of this thesis was to investigate the prevalence, temporal trends and associations to cardiovascular outcomes of blood pressure levels in patients in Västra Götaland. Methods and findings: In Study ... -
On the effects of obesity treatment
(2021-05-12)Aim: In this thesis the effects of bariatric surgery in individuals with type 1 diabetes (T1D) will be assessed as well as the effects of surgery on risk for heart failure (HF) and atrial fibrillation (AF) in individuals ... -
Managing irritable bowel syndrome - Dietary approaches and food intolerance
(2021-05-11)Irritable bowel syndrome (IBS) is a complex disorder where diet plays a pivotal role in symptom generation for many patients. The aim of this thesis was to explore how diet and self-perceived food intolerance relate to ... -
Blood and Bone - Epidemiological studies on the association between blood and bone
(2021-05-07)Introduction: Preclinical and clinical studies have suggested that blood- and bone cells are interconnected. Aims: To study the association between hematological variables, specifically serotonin, erythropoietin (EPO), ... -
Women’s health in midlife - a person-centered approach in primary care -effects on mental, somatic, and urogenital symptoms, and quality of life.
(2021-05-05)Midlife women, from 45-60, enter new challenges in life with various impacts on health and quality of life. Mental and stress-related illnesses are common causes for attending primary health care (PHC) and long-term sick ... -
Body weight, body size and early cardiovascular disease. Epidemiological studies using Swedish registries
(2021-05-04)Background: Obesity is a known risk factor for cardiovascular morbidity and mortality, as well as for atrial fibrillation and heart failure. While overweight and obesity have become increasingly more common in Sweden and ... -
Heart Failure and Aortic Stenosis - Factors Influencing Prognosis and Development
(2021-04-27)Background: An ageing population increases the prevalence of heart failure (HF) and aortic stenosis (AS). Several studies have investigated prognosis and predictors of HF with preserved ejection fraction (HFpEF) compared ... -
Childhood overweight and pubertal timing as predictors of adult cancer in men
(2021-04-27)Background and Aim Obesity is one of the leading causes of cancer globally. The importance of overweight in childhood for adult cancer risk, independent of overweight status in young adulthood is still unknown. Furthermore, ... -
Iodine intake and uptake in populations at risk for iodine deficiency
(2021-04-16)Background: Iodine is essential for the production of thyroid hormones. Both iodine deficiency (ID) and iodine excess may be harmful. Iodine intake in Sweden is considered adequate for the general population due to iodization ...