Doctoral Theses / Doktorsavhandlingar Institutionen för medicin: Recent submissions
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Utvecklad dialog om sexuell hälsa med fokus på unga kvinnor - en möjlighet vid det gynekologiska besöket
(2009-11-19)Background: Many women who have sexual problems or who have been subjected to sexual abuse do not seek help and health professionals often avoid raising such issues. The gynaecological encounter could be an opportunity ... -
Resistin is a modulator of inflammation and autoimmunity
(2009-11-18)Resistin is a protein with proinflammatory properties in man and a regulator of glucose metabolism in mice. Human resistin activates the nuclear factor kappa-B dependent cytokine cascade; however, its full role in ... -
The effect of hypoxia on macrophage proteoglycans: potential role in atherosclerosis
(2009-11-13)A critical step in the development of atherosclerotic lesions appears to be the retention of low density lipoproteins (LDL) in the arterial wall, mediated by negatively charged proteoglycans (PG). Retained LDL is susceptible ... -
The Importance of Isoprenylation and Nf1 Deficiency in K-RAS-induced Cancer
(2009-11-10)The RAS and RHO family proteins contribute to tumorigenesis and metastasis and belong to a family of so called CAAX proteins. The membrane targeting and proper function of CAAX proteins are dependent on posttranslational ... -
Telefonrådgivning - en verksamhet i tiden : studier ur ett patient- och sjuksköterskeperspektiv
(2009-11-10)Background : Care encounters and nurses’ advising over the phone are increasingly common in the Western world today. This new area in the profession needs more research due to its’ importance in daily life. Article I: ... -
Turner syndrome. Relation between genotype and phenotype and long-term follow-up studies.
(2009-11-02)Turner syndrome (TS) is a chromosomal disorder with a prevalence of approximately 1/2 500 live female births. There is complete or partial absence of one of the two sex chromosomes, resulting in a genetic constellation ... -
Wrist and thumb joint postures and motions - measurements using electrogoniometry and EMG
(2009-10-29)Correct measurements of the joints’ extreme postures, velocity and repetitiveness are important for studies of the origin of musculoskeletal disorders. Posture measurements of wrist and thumb joints may also provide insights ... -
Quality of life, school performance, treatment adherence and gender differences in asthma.
(2009-10-19)The aims of this thesis were to estimate the effectiveness of a computerized asthma education program designed to suit young people (I), to analyze whether quality of life changed over a five year period and whether young ... -
Genital tract CD4+ T cells for vaccination and protection against Chlamydia trachomatis
(2009-10-19)Vaccination strategies for protection against sexually transmitted diseases (STDs) are lacking due to an incomplete understanding of genital tract T cell responses. This thesis dissects the generation of T helper subsets, ... -
Development of a New Biomechanical ex vivo Perfusion System - Studies on effects of biomechanical and inflammatory stress on hemostatic genes in human vascular endothelium
(2009-10-06)The vascular endothelium is a multifunctional interface constantly exposed to biomechanical forces such as shear and tensile stress. Biomechanical stress is involved in the pathophysiological process of the vessel wall and ... -
Cardiovascular regulation and vascular structure in prehypertension and coronary heart disease
(2009-10-06)The aim of this thesis was to characterize vascular structure and different aspects of cardiovascular regulation in otherwise healthy subjects with slightly elevated blood pressure and compare to healthy subjects with ... -
Aspects of Intraoperative Ablation for Atrial Fibrillation
(2009-08-28)Background: Increasing knowledge about mechanisms that trigger and maintain atrial fibrillation (AF) has influenced the possibilities for treatment and even cure of AF. The surgical Cox Maze III procedure is still the gold ... -
GH/IGF-I axis regulation of cardiovascular and neuronal gene expression and function
(2009-08-24)Abstract Cardiovascular disease is a major cause of mortality in the Western world. Another important clinical condition is brain damage due to radiation therapy in cancer patients. This has neurological impairments ... -
Pathogenesis of Obesity and Effects of Treatment. Clinical and Molecular Studies on Body Fat, Energy Balance, and Weight Loss.
(2009-06-29)Obesity is common and related to many health problems including various forms of cancer. The condition arises from the imbalance between food intake and energy expenditure, and is strongly influenced by genetic factors. ... -
Computer-Assisted Diagnosis for the Interpretation of Bone Scintigraphy. A new approach to improve diagnostic accuracy.
(2009-05-26)The most common cancers in the western countries are breast cancer in women and prostate cancer in men, and these cancer types, together with lung cancer, often metastasise to the skeleton. Bone scan is used to determine ... -
Physical activity and energy expenditure in clinical settings using multisensor activity monitors.
(2009-05-20)Background: Objective methods need to replace subjective methods for accurate quantification of physical activity. To be used in clinical settings objective methods have to show high reliability, validity and feasibility. ... -
Physical exposure, musculoskeletal symptoms and attitudes related to ICT use
(2009-05-20)High prevalence of musculoskeletal symptoms/disorders in neck and upper extremities are reported among computer users. Considering the widespread use of information and communication technology (ICT) and mobile phones ... -
Psychosomatic aspects of women's health - results from the Prospective Population Study of Women in Gothenburg
(2009-05-12)Aim: The aim of this thesis was to study prevalence of perceived nervousness and mental stress in a female population and to investigate associations between perceived nervousness and mental stress and psychosomatic symptoms ... -
Activation of professional phagocytes with emphasis on the formyl peptide receptor family
(2009-05-08)Phagocytic cells such as neutrophil granulocytes and monocytes are an essential part of our innate immune system and play an important role in the battle against pathogens. G-protein coupled receptors (GPCRs) and more ...