Doctoral Theses / Doktorsavhandlingar Institutionen för medicin: Recent submissions
Now showing items 481-500 of 570
-
Sex steroid metabolism and body composition
(2009-04-30)Background: The bioactive androgens testosterone (T) and dihydrotestosterone (DHT) regulate bone and fat mass in men. The effects of androgens are largely determined by the rate of their synthesis and inactivation. ... -
Defining RCE1 and ICMT as Therapeutic Targets in K-RAS-induced Cancer
(2009-04-09)CAAX proteins, such as the RAS and RHO proteins, are recognized by a specific CAAX motif at the carboxyl terminus, which undergoes posttranslational modifications. First, a lipid group is attached to the cysteine (the “C”) ... -
Exposure to some carcinogenic compounds in air, with special reference to wood smoke
(2009-04-06)The general population is exposed to air pollutants in both indoor and outdoor air from many different sources, including traffic, biomass burning, industries, cigarette smoking, and certain building materials. Air pollutants ... -
Glycaemic control: evaluation of HbA1c as a risk factor and the effect of modern insulins in clinical practice
(2009-04-02)One of the ultimate goals of diabetes care is to minimise diabetic complications. When evaluating insulins it is important to understand what extent of improvements in glycaemic control is clinically relevant in preventing ... -
Aspects of diagnosis and treatment of hypopituitarism in adult life
(2009-02-27)Management of adult patients with hypopituitarism can improve with better char¬ac¬terisation of idiopathic pituitary insufficiency (IPI) and clearer diagnosis of central hy¬pothy¬roidism (CH). Moreover, optimised treatment ... -
Functional dualism of antimicrobial host defence peptides
(2009-01-26)Antimicrobial host defence peptides are central to innate immunity and many possess direct antimicrobial actions on bacteria as well as indirect immunomodulatory functions on human leukocytes. Different variants of the ... -
Manifestations and Survival in Coronary Heart Disease
(2009-01-15)Aim: To investigate how risk factors predict manifestations in coronary heart disease (CHD), and trends in short-term and long-term survival including trends in out-of-hospital mortality. Populations and methods: In the ... -
Studies on the atherogenicity of apoB-containing lipoproteins in type 2 diabetes
(2009-01-15)Type 2 diabetes (T2D) and the metabolic syndrome (MetS), two conditions that are rapidly increasing in prevalence, as well as the dyslipoproteinemia and subclinical inflammation characteristic for these conditions, are ... -
COMT Genotype, sex steroids, and bone phenotype in mice and men
(2009-01-15)COMT GENOTYPE, SEX STEROIDS AND BONE PHENOTYPE IN MAN AND MICE Anna-Lena Eriksson Institute of Medicine, University of Gothenburg, Göteborg, Sweden, 2008 ... -
THE ANGIOGENIC RESPONSE IN HYPOXIC HEART. Experimental studies in mice.
(2009-01-14)Coronary artery disease is the leading cause of death in the western world today. Although induction of angiogenesis would appear to be an ideal therapeutic strategy, clinical trials of proangiogenic factors have proved ... -
A role of CD44 in atherosclerosis? Studies in mice and humans
(2009-01-12)Atherosclerosis is an inflammatory disease that can lead to clinical complications such as myocardial infarction and stroke. Expressed in both vascular and inflammatory cells, adhesion molecule CD44 can be cleaved from the ... -
Impact of Risk Factors and Treatment in Coronary Heart Disease
(2008-12-04)Aims: The aim of the present study was to explore how risk factors and medication influence clinical presentation and mortality in coronary heart disease (CHD) and to explain how much of the decrease in CHD mortality in ... -
Osteoporosis in SLE
(2008-12-03)As the treatment of Systemic Lupus Erythematosus (SLE) has become more effective the focus has partly shifted from main concern of short term morbidity and survival to long term complications such as osteoporosis. The aims ... -
The role of exosomes and microflora in establishing mucosal tolerance and the protection against allergic disease
(2008-12-02)The role of exosomes and microflora in establishing mucosal tolerance and the protection against allergic disease Nina Almqvist, Departement of Rheumatology and Inflammation Research, The Sahlgrenska Academy University ... -
Pulmonary hypertension. Clinical and pathophysiological studies
(2008-11-28)Pulmonary hypertension (PH) is a common abnormality, most often associated with various cardiopulmonary diseases. Pulmonary arterial hypertension (PAH) is a devastating pulmonary vascular disease characterised by the ... -
Factors of importance for health care seeking in irritable bowel syndrome and the use of patient education.
(2008-11-13)Irritable bowel syndrome (IBS) is a common functional gastrointestinal (GI) disorder. The etiology and pathophysiology are incompletely understood and treatment options are limited. IBS is a benign disease, but many patients ... -
Expression profiling of human macrophages and atherosclerotic plaques to identify genes and mechanisms that modulate the development of atherosclerosis
(2008-11-10)Macrophages play an important role in atherosclerosis, a disease that affects large and medium size arteries and causes clinical manifestations such as myocardial infarction or stroke. The aim of this thesis was to ... -
Nya utmaningar, gamla strategier - om distriktsläkares yrkesroll och attityder till samarbete
(2008-11-10)Background: Being confronted by patients with incurable chronic and psychosocially complicated conditions constitutes one of the major challenges for today’s General Practitioners (GP). The traditional biomedical disease ... -
The importance of long axis function -an echocardiographic study with respect to ageing, response to treatment, prediction of survival and effect of warm water immersion
(2008-10-17)Echocardiographic M-mode measurement of atrioventricular plane displacement (AVPD) and determination of annular velocity with Tissue Doppler imaging (TDI) is a reliable method to gauge ventricular long axis function for ... -
Domestic Workload and Multiple Roles. Epidemiological findings on health and sickness absence in women
(2008-10-16)Aim: The objective of this thesis was to analyse the importance of specific exposures in women’s lives to health and sickness absence; more precisely to study the association between domestic work, multiple roles and the ...