Doctoral Theses / Doktorsavhandlingar Institutionen för medicin: Recent submissions
Now showing items 341-360 of 570
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Hemodynamic, hemostatic and inflammatory effects of cardiotomy suction blood in cardiac surgery
(2013-10-14)ABSTRACT Background: Cardiac surgery with cardiopulmonary bypass induces an inflammatory response and a coagulopathy, which may contribute to perioperative complications. Retransfusion of unprocessed cardiotomy suction ... -
Diagnosis & dietary intervention in patients with diabetic gastroparesis
(2013-09-03)Background: Gastroparesis is a diabetic complication, which is often under-recognised. Existing treatment options are limited and diagnostic methods not easily accessible. Aims of the thesis: To compare two alternative ... -
Lifesaving after cardiac arrest due to drowning. Characteristics and outcome
(2013-09-03)Aims The aim of this thesis was to describe out-of-hospital cardiac arrest (OHCA) due to drowning from the following angles. In Paper I: To describe the characteristics of OHCA due to drowning and evaluate factors of ... -
Women and acute myocardial infarction - studies of symptoms, mortality and prognosis
(2013-08-29)The primary aim of this thesis was to investigate recent data regarding sex differences in symptoms, mortality and case fatality in coronary heart disease (CHD), with the ultimate aim to increase knowledge about women and ... -
Vectorcardiographic evaluation of ventricular repolarization in healthy individuals and LQTS mutation carriers
(2013-08-27)Ventricular arrhythmia is a well-known cause of syncopal attacks and sudden cardiac death in humans. Ventricular repolarization (VR) is the most unstable phase in cardiac electrical activity and its regulation depends on ... -
Bacteria-host interplay in Staphylococcus aureus infections
(2013-06-05)Staphylococcus aureus infections are a major healthcare challenge and new treatment alternatives are needed. The key to new therapies is understanding the interplay between bacterial virulence factors and host immune ... -
Prevalence, risk factors and comorbidity of rhinitis, asthma and aspirin-intolerance in West Sweden
(2013-05-24)The prevalence of rhinitis and asthma has increased considerably over the past century. The cause of this increase remains unknown. Furthermore, rhinitis and asthma are now considered heterogeneous syndromes encompassing ... -
Cardiopulmonary resuscitation in Sweden - yesterday, today and tomorrow
(2013-05-21)In Sweden, the reported incidence and outcome of out-of-hospital cardiac arrest (OHCA) vary between counties. In the mid -1980s, a national programme in cardiopulmonary resuscitation (CPR) was developed and rescuers have ... -
The Clinical Relevance and Potential Mechanism of Biomarkers in Elderly Heart Failure Patients
(2013-05-08)Aim: To study the clinical relevance and potential mechanism of biomarkers in elderly heart failure (HF) patients. Methods: A retrospective study was conducted by access to Swedish Heart Failure Registry with focus on ... -
Receptor Cross-talk and Neutrophil Function
(2013-05-08)The chemotactic recruitment of neutrophils, the most abundant white blood cell in human circulation, to sites of infection and inflammation, is dependent upon a gradient of chemoattractants released from cells at the ... -
Endocrine and diagnostic aspects of cognitive impairment
(2013-04-30)Hormones like insulin-like growth factor-I (IGF-I), thyroid hormones, and sex steroids decrease with normal aging. It is, however, unclear whether low hormone levels are related to age-related conditions such as Alzheimer’s ... -
Self-tolerance in collagen induced arthritis
(2013-04-29)Rheumatoid arthritis (RA) is an autoimmune chronic disease that results in damage to tissues throughout the body due to the inability of the immune system in these patients to discriminate between self-tissues and foreign ... -
Hypertension and cardiovascular risk factors in women - a follow-up study forty years after hypertensive pregnancies
(2013-04-03)The aims of the thesis were to investigate the impact of pregnancy blood pressure, a current diagnosis of hypertension and blood pressure levels on neurohumoral, cardiovascular and metabolic status in postmenopausal women ... -
Impact of the GH-IGF-I axis in adults - pharmacogenetic and genetic association studies
(2013-03-28)Growth hormone (GH) is a polypeptide hormone which is secreted from the anterior pituitary in a pulsatile pattern. GH is best known by its strong effects on longitudinal growth in children, but the importance of GH is ... -
Environmental exposure to fine particles in Gothenburg - personal exposure and its variability, indoor and outdoor levels, and effects on biomarkers
(2013-03-25)Urban particulate air pollution has been associated with adverse health effects in epidemiological as well as experimental studies. The overall aim of this thesis was to characterize environmental exposure to fine particles ... -
Clinical study on osteoporosis in ankylosing spondylitis
(2013-03-25)ABSTRACT Ankylosing spondylitis (AS) is a disease characterized by chronic inflammation and osteoproliferation in the spine, leading to bony fusion (ankylosis) of the sacroiliacal joints, the growth of bony spurs ... -
Regulation of metabolism and inflammation in liver and skeletal muscle
(2013-02-19)Type 2 diabetes (T2D) is a complex metabolic disorder characterised by hyperinsulinaemia, hyperglycaemia and dyslipidaemia. Obesity is the major risk factor for development of insulin resistance, a main predictor of T2D. ... -
Primary Sclerosing Cholangitis. Epidemiological Aspects, Prevalence of Elevated IgG4 levels and Quality of Life.
(2013-02-08)ABSTRACT Primary Sclerosing Cholangitis: Epidemiological Aspects, Prevalence of Elevated IgG4 Levels, and Quality of Life Maria Benito de Valle, MD Department of Internal Medicine and Clinical Nutrition, Sahlgrenska ... -
Determinants of Peak Bone Mass in Men
(2013-01-25)Objective: The aim of this thesis was to identify, investigate and evaluate hereditary and environmental factors associated with peak bone mass or bone development in men. Method: All studies in the thesis were performed ... -
Exosomes and Exosomal RNA – A Way of Cell-to-Cell Communication
(2013-01-22)Exosomes are nano-sized extracellular vesicles of endocytic origin participating in cell-to-cell communication, partly by the transfer of exosomal RNA between cells. These extracellular vesicles are released by most cells ...