Doctoral Theses / Doktorsavhandlingar Institutionen för medicin: Recent submissions
Now showing items 361-380 of 570
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Quality of drug treatment in older people - Focus on hip fracture patients and multi-dose drug dispensing
(2013-01-14)The aim of this thesis was to describe the quality of drug treatment (QDT) regarding fall-risk increasing (FRIDs) and fracture-preventing (FPDs) drugs in older hip fracture patients, to evaluate a method for improving such ... -
Optimizing the early treatment of a threatening myocardial infarction
(2013-01-09)Acute myocardial infarction is the single most common cause of death for both women and men in Sweden. Great efforts have, over the years, been made to improve immediate treatment and care of acute coronary syndromes. Through ... -
The role of estrogen receptor alpha in the regulation of bone and growth plate cartilage
(2012-12-20)Estrogens are important endocrine regulators of skeletal growth and maintenance in both females and males. Studies have demonstrated that the estrogen receptor (ER)-α is the main mediator of these estrogenic effects in ... -
Arthritis and immune-mediated bone loss - role of estrogen signalling pathways
(2012-12-13)Objective: Rheumatoid arthritis (RA) is associated with immune-mediated bone loss and thereby increased risk for fractures. Estrogen and selective estrogen receptor modulators (SERMs) ameliorate not only the incidence and ... -
Asthma in West Sweden - a translational study from epidemiology to proteomics
(2012-11-20)Asthma has been increasing in prevalence and morbidity, however it is unclear if the increase continues. Asthma has long been regarded as a single disease entity, but is now recognised as a heterogenic disease with different ... -
The role of melanocortin 1 receptor in kidney disease
(2012-11-15)Nephrotic syndrome is a term describing a group of poorly understood glomerular diseases that are responsible for a steadily increasing number of patients requiring active uremic care. Characteristic symptoms of nephrotic ... -
Diet and/or exercise treatment for weight loss in overweight and obese women after childbirth
(2012-11-15)AIM: The aim of the research presented in this thesis was to evaluate whether, dietary behavior modification treatment (D), or physical exercise behavior modification treatment (E), or the combination of both (DE), provide ... -
Implementation of gut-directed hypnotherapy for irritable bowel syndrome in clinical practice
(2012-11-14)Background: Irritable Bowel Syndrome (IBS) is characterized by recurrent abdominal pain or discomfort, related to abnormal bowel habits. This benign and common condition is in severe cases associated with bothersome GI ... -
Long-term effects of growth hormone replacement in hypopituitary adults on body composition, bone mass and cardiovascular risk factors
(2012-11-06)Growth hormone (GH) deficient (GHD) adults have decreased bone mass and muscle strength, impaired body composition, disturbed serum lipid pattern and increased morbidity and mortality in cardiovascular and cerebrovascular ... -
Mild to moderate depression in the elderly in primary care - detection, patient centeredness and course
(2012-11-02)Aims; To study the prevalence of and describe factors associated with depressive symptoms and to observe the course in a cohort of elderly primary care patients with mild to moderate depression. To compare a structured ... -
Exercise and physical activity in relation to kinesiophobia and cardiac risk markers in coronary artery disease
(2012-10-26)Coronary artery disease (CAD) is the leading cause of death worldwide. Patients who have survived a coronary event are the highest priority for secondary prevention. In the secondary prevention of CAD, strong evidence of ... -
Problematic medication use in headache - Epidemiology and qualitative aspects of medication overuse headache and non-adherence to prophylactic migraine treatment
(2012-10-26)Aim: The aim was to analyze problematic medication use among persons with headache, focusing on overuse of acute medications, with subsequent medication overuse headache (MOH), and on underuse of prophylactic medication. ... -
Effects of immunosuppressive drugs on human adipose tissue metabolism
(2012-10-26)The immunosuppressive agents (IAs) rapamycin, cyclosporin A and tacrolimus, as well as glucocorticoids are used to prevent rejection of transplanted organs and to treat autoimmune disorders. Despite their desired action ... -
Dietary energy density and energy intake in cancer patients
(2012-10-25)Background & Aims: Cachexia is frequent in advanced cancer and is associated with adverse outcomes; however, definite diagnostic criteria for cachexia are not established. Diet energy density (ED) may affect energy intake ... -
Cardiovascular structure and function in obesity. The impact of body composition, sleep apnea and sustained weight loss
(2012-10-23)Background: Obesity is associated with disturbances in cardiovascular structure and function varying along with the degree of fatness, but the mechanisms underlying this co-variation are unclear. Short-term weight loss ... -
Prediction Models and Pharmacogenomics in Adult Growth Hormone Deficiency
(2012-10-10)The overall aim of this thesis was to study clinical and genetic factors that influence response to growth hormone replacement therapy (GHRT) in GH deficient (GHD) adults. The patients were part of a cohort of adults with ... -
Implementation of research and development in primary care by means of strategic communication
(2012-10-08)Background: Health and medical care today is faced with the challenge of bridging the gap between the theoretical world and the practical clinical setting. Although methods exist for implementing research results, the ... -
Prescribing drugs in primary health care - Thoughts, information strategy and outcome
(2012-10-08)Aims: General aim; to investigate whether tailored evidence-based drug information provided to general practitioners can be implemented more effectively than evidence-based drug information provided as usual. Specific aims; ... -
Dietary intake of naturally occurring plant sterols in relation to serum cholesterol and myocardial infarction - Epidemiological studies from Sweden and the UK
(2012-09-21)Cardiovascular diseases (CVDs) are the leading cause of death in the world. High serum level of cholesterol is one of the major risk factors for CVD development. Serum levels of cholesterol can be modified by diet. Generally, ... -
Nonfatal injuries in a local context - Analysing social structures and perceptions in young people
(2012-05-24)Background: Injuries are a common health problem in children and young people. The uneven distribution over gender and socioeconomic groups is partly explained by factors at both the individual and family levels, but ...